Cannabis based therapeutic and method of use

ABSTRACT

The present disclosure relates to cannabinoid-based therapeutics, and their use in treating pain, e.g., chronic pain. The present disclosure also relates to cannabinoid-based therapeutics, and their use in treating opioid addiction.

CROSS-REFERENCE

This application is a continuation of U.S. application Ser. No. 18/131,052, filed Apr. 5, 2023, which is a continuation of U.S. application Ser. No. 16/971,781, filed Aug. 21, 2020, now U.S. Pat. No. 11,684,604 B2, issued on Jun. 27, 2023, which is a National Stage Application of International Application No. PCT/US2019/019465, filed Feb. 25, 2019, which claims the benefit of U.S. Provisional Application No. 62/634,547, filed Feb. 23, 2018, the disclosures of which are incorporated herein by reference in their entirety.

BACKGROUND OF THE INVENTION

There is a need in the art for methods and compositions to manage pain, e.g., chronic pain. There is also a need in the art for methods and compositions for treating opioid addiction.

SUMMARY OF THE INVENTION

Disclosed herein are pharmaceutical compositions comprising: tetrahydrocannabinol (THC) and cannabidiol (CBD) in a THC:CBD ratio of from 1:1.5 to 3:1 by weight; and one or more terpenes. In some embodiments, the THC:CBD ratio is from 1.5:1 to 2:1. In some embodiments, the THC:CBD ratio is about 1.5:1.

In some embodiments, the pharmaceutical composition comprises about 15-20 mg tetrahydrocannabinol (THC) per dose. In some embodiments, the pharmaceutical composition comprises 10-12 mg cannabidiol (CBD).

In some embodiments, the one or more terpenes comprise β-myrcene, β-caryophyllene, ocimene, α-pinene, α-humulene, linalool, p-cymene, camphene, cis-nerolidol, terpinolene, isopulegol, caryophyllene oxide, δ-limonene, geraniol, guaiol, α-bisabolol, 3-carene, β-pinene, γ-terpinene, or a combination thereof. In some embodiments, rein the one or more terpenes comprise β-myrcene, β-caryophyllene, ocimene, α-pinene, and α-humulene.

In some embodiments, the one or more terpenes comprise β-myrcene, and wherein the pharmaceutical composition comprises 30-60 mg of β-myrcene per dose.

In some embodiments, the one or more terpenes comprise β-caryophyllene, and wherein the pharmaceutical composition comprises 2.5-5 mg of β-caryophyllene per dose.

In some embodiments, the one or more terpenes comprise ocimene, and wherein the pharmaceutical composition comprises 2.3-4.7 mg of ocimene per dose.

In some embodiments, the one or more terpenes comprise α-pinene, and wherein the pharmaceutical composition comprises 1.1-2.1 mg of α-pinene per dose.

In some embodiments, the one or more terpenes comprise α-humulene, and wherein the pharmaceutical composition comprises 0.8-1.6 mg of α-humulene per dose.

In some embodiments, the one or more terpenes comprise β-myrcene, β-caryophyllene, ocimene, α-pinene, and α-humulene; and wherein the pharmaceutical composition comprises about 30-60 mg of the β-myrcene, about 2.5-5 mg of the β-caryophyllene, about 2.3-4.7 mg of the ocimene, about 1.1-2.1 mg of the α-pinene, and about 0.8-1.6 mg of the α-humulene per dose.

In some embodiments, the pharmaceutical composition is formulated as a liquid, a pill, a gel capsule, a vaporizable liquid, a vaporizable solid, a transdermal ointment or salve, or a transdermal patch.

In some embodiments, the pharmaceutical composition is formulated as a liquid. In some embodiments, the liquid comprises citric acid, blue agave, glycerine, one or more lorann oils, food coloring, or a combination thereof.

In some embodiments, the liquid comprises: about 1% to 7% w/w citric acid; about 40% to 49% w/w blue agave; about 40% to 49% w/w glycerin; about 0.1% to 1.5% w/w lorann oils; about 0.01 to 0.4% food coloring; or a combination thereof. In some embodiments, the liquid comprises: about 3-5% w/w citric acid; about 45-49% w/w blue agave; about 45-49% w/w glycerin; about 0.7-0.9% w/w lorann oils; and about 0.1-0.3% food coloring.

In some embodiments, the pharmaceutical composition is for use in the treatment of opioid addiction.

In some embodiments, the pharmaceutical composition is for use in the treatment of pain.

In some embodiments, the pharmaceutical composition is for use in the treatment of chemotherapy-induced nausea and vomiting.

Also disclosed herein are methods of treating opioid addition, the methods comprising administering an effective amount of a pharmaceutical composition comprising one or more cannabinoids to a subject in need thereof. The pharmaceutical composition can be any pharmaceutical composition disclosed herein.

In some embodiments, the pharmaceutical composition is administered every 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, or 24 hours.

In some embodiments, the pharmaceutical composition is administered every 6, 8 or 12 hours.

In some embodiments, the subjects opioid use decreases by at least 50% within 5 weeks of beginning treatment as determined by morphine equivalency of opioids used.

INCORPORATION BY REFERENCE

All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference. In the event that a term incorporated by reference conflicts with a term defined herein, this specification shall control.

BRIEF DESCRIPTION OF THE DRAWINGS

The novel features of the invention are set forth with particularity in the appended claims. A better understanding of the features and advantages of the present invention will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the invention are utilized, and the accompanying drawings of which:

FIG. 1 a &b illustrates weekly pill counts in chart form (FIG. 1 a ) and graph form with regression analysis (FIG. 1 b ).

FIG. 2 a &b illustrates weekly pill counts in morphine equivalents in tabular form (FIG. 2 a ) and graph form with regression analysis (FIG. 2 b ).

DETAILED DESCRIPTION OF THE INVENTION

The present disclosure relates to therapeutics, and more especially the use of cannabinoid-based therapeutics, for use in treating those known to have chronic pain. In some cases, the chronic pain may have been treated using opiates. The present disclosure also relates to cannabinoid-based therapeutics for use in treating opioid addiction.

Introduction

In the United States the estimated total annual cost of pain-related health is approximately $600 billion and perhaps this figure is even higher for the nations in European Union (EU). This estimate includes the actual costs related to the medical care as well as the economic losses which contribute to approximately one-half of these costs. Economic losses include claimed disability, loss of productivity and lost wages. Medical care including physician time, hospitalization, surgical procedures, diagnostic testing and prescription drugs all contribute to the costs associated with the treatment of pain, as well the costs associated with the adverse effects associated with their utilization. Unfortunately, one of the adverse effects associated with prescription painkillers is death. Overdose deaths secondary to prescription opioids were five times higher in 2016 than 1999 and sales of these prescription drugs have quadrupled. That being said, the number of deaths dues to prescription opioids has remained relative stable at approximately 14,000 to 16,000 deaths per year. Much of the increase in mortality related to opioid consumption is due the rapid rise in those associated with the use of synthetic opioids. In states with either medical marijuana or both medical and retail marijuana programs in place there was a 24.8% lower mean annual opioid overdose mortality rate (95% CI, −37.5% to −9.5%: P=0.003) compared with states without medical marijuana laws.

Addressing the opiate crisis in this country has led to a number of studies being conducted using cannabis-based therapy as an alternative means of managing chronic and cancer-related pain. Despite Nabiximols not appearing to be statistically superior when compared to placebo in controlling pain in cancer patients, there are other randomized placebo controlled trials demonstrating the efficacy of using cannabis for pain control. There is also significant evidence that a cannabis-opioid interaction exists that results in improved pain control. All of the studies to date have either used pain scales or patient interview results to determine the success or failure of the cannabis intervention.

A group of physicians in Nevada, licensed to cultivate, produce and sell cannabis-related products and have recently undertaken a two phase II trials ran using a guava-based syrup with a THC:CBD ratio of 2:1 and at a 1:1 ratio containing only the flavored guava-based syrup. Each dose of syrup contained either 10 mg/ml of both delta-9-tetracannabinol (THC) and cannabidiol (CBD) or 20 mg of THC and 10 mg of CBD. As a proof of concept 25 patients in each group with a history of at least 3 years of chronic opiate use were enrolled in a single arm study with the endpoint being a 30% reduction of opiate intake determined by weekly pill count. 23 of the 25 patients reduced their opiate intake by greater than 50%. This provides an objective basis to evaluate the potential of cannabis to reduce the opiate consumption across the US.

The claimed beneficial medicinal effects associated with cannabis consumption are quite diverse and of long-standing. In 1889, some of these benefits were first described in the medical literature by Dr. E. A. Birch. Of the claims made, the most studied are in patients with multiple sclerosis, where a beneficial effect on muscle spasticity and pain are well-documented, but not necessarily as consistently as one might like. Cannabis has also been shown to be effective in treating seizures, anorexia, chronic pain, and nausea and vomiting that is associated with chemotherapy. There is some evidence that cannabidiols have a therapeutic effect of inflammation, chronic pain, diabetes, cancer, and neurodegenerative diseases.

To understand the underlying basis for the use of cannabinoids in the treatment of chronic pain it is imperative to understand their likely mechanisms of action. Cannabis contains at least 63 cannabinoids but two are best understood studied. The first, delta-9 tetrahydrocannabinol (THC), is responsible for the psychoactive effects that is widely associated with cannabis. The other main active component, cannabidiol (CBD), has no psychoactive effect associated with its consumption but is thought to provide anti-neoplastic, analgesic and antineuroleptic effects per the literature. Even though both cannabinoids are present in every plant, the interactions with the cerebral endocannabinoid receptor system are quite different. CBD binds as an antagonist to the cannabinoid receptor CB1 but the bond between THC and the same receptor is at least 100 times stronger. CBD also antagonizes the action on the cannabinoid G protein-coupled receptor GPR55, which is thought to be responsible the different neuromodulatory actions as the CB1 receptor. Claims of the subjective effects associated with cannabis ingestion include improvement in mood; relaxation; and increased sensitivity. On the other hand THC ingestion has been associated with less than desirable adverse effects such as agitation; panic disorder; depression and even psychosis.

Cannabinoids have an effect on serotonergic systems, including increasing cerebral production of 5-hydroxytryptamine (5-HT), serotonin while decreasing its uptake at the synapse level. THC has been found to have dopaminergic antagonistic actions which may contribute to its beneficial profile regarding pain control.

Other phytocannabinoids such as cannabichromene (CBC), cannabigerol (CBG) as well as a number of terpenoids likely contribute its analgesic effect. CBC and CBG have significant anti-inflamatory and analgesic effects over and beyond that associated with THC. B-caryophyllene has been shown to be a selective CB2 agonist and other terpenes such as linalool and α-Pinene have analgesic and anti-inflamatory effects respectively. Myrcene other the other hand has been shown to have analgesic effects mediated through an opioid-like action. This is an important development as it helps explain another avenue as to how cannabis and it component parts may prevent opiate withdrawal and allow for the use of lesser amounts of opioids while preventing the development of tolerance. Used in combination with opioid pain medications, cannabis can lower opioid side effects, cravings, and withdrawal severity, as well as enhance the analgesic effects of opioids, thereby allowing for lower doses and less risk of overdose.

As explained above the actions of THC, CBD, associated terpenes are potentially complementary and there is substantial evidence to suggest benefit of using together for patients with chronic pain.

Embodiments of the Disclosure

An embodiment of the present disclosure is the therapeutic compound for the use in treating chronic pain and like disorders and preferably in liquid form compromising a formulation including cannabinoids, but not limited to delta-9-tetrahydrocannabinol and cannabidiol. The compound may optionally include any terpene or terpinoid present in a cannabis plant. A subject suffering from chronic pain is orally administered a therapeutically effective amount of the compound so as to alleviate, cure or prevent the symptoms associated with chronic pain.

Another embodiment of the present disclosure is the therapeutic compound for the use in treating chronic pain and like disorders and preferably in a pill form compromising a formulation including cannabinoids, but not limited to delta-9-tetrahydrocannabinol and cannabidiol. The compound may optionally include any terpene or terpinoid present in a cannabis plant. A subject suffering from chronic pain is orally administered a therapeutically effective amount of the compound so as to alleviate, cure or prevent the symptoms associated with chronic pain.

Another embodiment of the present disclosure is the therapeutic compound for the use in treating chronic pain and like disorders and preferably in suppository form compromising a formulation including cannabinoids, but not limited to delta-9-tetrahydrocannabinol and cannabidiol. The compound may optionally include any terpene or terpinoid present in a cannabis plant. A subject suffering from chronic pain is orally administered a therapeutically effective amount of the compound so as to alleviate, cure or prevent the symptoms associated with chronic pain.

Another embodiment of the present disclosure is the therapeutic compound for the use in treating chronic pain and like disorders and preferably in capsule form compromising a formulation including cannabinoids, but not limited to delta-9-tetrahydrocannabinol and cannabidiol. The compound may optionally include any terpene or terpinoid present in a cannabis plant. A subject suffering from chronic pain is orally administered a therapeutically effective amount of the compound so as to alleviate, cure or prevent the symptoms associated with chronic pain.

Another embodiment of the present disclosure is the therapeutic compound for the use in treating chronic pain and like disorders and preferably in a transdermal form compromising a formulation including cannabinoids, but not limited to delta-9-tetrahydrocannabinol and cannabidiol. The compound may optionally include any terpene or terpinoid present in a cannabis plant. A subject suffering from chronic pain is transdermally administered a therapeutically effective amount of the compound so as to alleviate, cure or prevent the symptoms associated with chronic pain.

Another embodiment of the present disclosure is the therapeutic compound for the use in treating chronic pain and like disorders and preferably in an inhalable/nebulized form compromising a formulation including cannabinoids, but not limited to delta-9-tetrahydrocannabinol and cannabidiol. The compound may optionally include any terpene or terpinoid present in a cannabis plant. A subject suffering from chronic pain is inhaled in a therapeutically effective amount of the compound so as to alleviate, cure or prevent the symptoms associated with chronic pain.

It shall be noted that the cannabinoid disclosed herein may include any of the identified cannabinoids, but not limited to THC (Tetrahydrocannabinol); THCA (Tetrahydrocannabinolic acid); CBD (Cannabidiol); CBDA (Cannabidiolic Acid); CBN (Cannabinol); CBG (Cannabigerol); CBC (Cannabichromene); CBL (Cannabicyclol); CBV (Cannabivarin); THCV (Tetrahydrocannabivarin); CBDV (Cannabidivarin); CBCV (Cannabichromevarin); CBGV (Cannabigerovarin); CBGM (Cannabigerol Monomethyl Ether); CBE (Cannabielsoin); CBT (Cannabicitran); (OTHC) 10-Oxo-delta-6a-tetrahydrocannabinol; (CBCF) Cannabichromanon; (CBF) Cannabifuran; Cannabiglendol; (CBR) Cannabiripsol; (CBT) Cannbicitran; (DCBF) Dehydrocannabifuran; (cis-THC) Delta-9-cis-tetrahydrocannabinol; (triOH-THC) Tryhydroxy-delta-9-tetrahydrocannabinol; and OH-iso-HHCV.

It shall also be noted that the terpene disclosed herein may, but is not limited to, any single or combination of the terpenes listed in table 1.

TABLE 1 List of exemplary terpenes RI No. chemical name (DB1) formula MW 1 Fusicocca-3,5-diene 1850 C20H32 272 2 9-epi-Sclarene 1896 C20H32 272 3 Laurenene 1903 C20H32 272 4 Rimuene 1907 C20H32 272 5 Isopimara-8,15-diene 1922 C20H32 272 6 Cembrene 1938 C20H32 272 7 Pimara-8,15-diene 1942 C20H32 272 8 Sclarene 1943 C20H32 272 9 Isohibaene 1944 C20H32 272 10 Rosa-5,15-diene 1945 C20H32 272 11 (E)-2,6-Dimethyl-10-(p-tolyl)- 1945 C20H30 270 undeca-2,6-diene 12 Isocembrene 1951 C20H32 272 13 Beyerene 1951 C20H32 272 14 Pimara-8(14),15-diene 1955 C20H32 272 15 Cembrene A 1962 C20H32 272 16 Labda-7,13,14-triene 1978 C20H32 272 17 Isopimara-8(14),15-diene 1981 C20H32 272 18 Isophyllocladene 1982 C20H32 272 19 Dolabella-6,10,15-triene 1984 C20H32 272 20 (Z)-Biformene 1988 C20H32 272 21 Manool oxide 2007 C20H34O 290 22 Geranyllinalool 2008 C20H32 272 23 Isopimara-7,15-diene 2010 C20H32 272 24 15-Kaurene 2011 C20H32 272 25 Isopimara-8,15-diene 2016 C20H32 272 26 Dolabradiene 2017 C20H32 272 27 Trachylobane 2022 C20H32 272 28 (E)-Biformene 2017 C20H32 272 29 Cembrene C 2023 C20H32 272 30 13-epi-Manoyl oxide 2023 C20H34O 290 31 (E)-Labda-7,12,14-triene 2036 C20H32 272 32 Phyllocladene 2042 C20H32 272 33 Abietatriene 2046 C20H30 270 34 16-Atisirene 2051 C20H32 272 35 16-Kaurene 2056 C20H32 272 36 Manool 2070 C20H32 272 37 Aphidicol-15-ene 2073 C20H32 272 38 Valpara-2,15-diene 2073 C20H32 272 39 Abieta-7,13-diene 2084 C20H32 272 40 Labda-7,14-dien-13-ol 2096 C20H34O 290 41 Aphidicol-16-ene 2102 C20H32 272 42 Isoabienol 2124 C20H34O 290 43 Abieta-8(14),13(15)-diene 2152 C20H32 272 44 (8a,12Z)-Abienol 2146 C20H34O 290 45 Incensole 2193 C20H34O2 306 46 Sclareol 2231 C20H36O2 308 47 Labda-8(17),14-dien-6,13-diol 2248 C20H34O2 306 48 Incensol acetate 2220 C22H36O3 348 49 Verticilla-4(20),7,11-triene 2040 C20H32 272 50 m-Camphorene 1947 C20H32 272 51 p-Camphorene 1980 C20H32 272 52 Cembrenol 2131 C20H34O 290 53 Sterna-13-ene 2025 C20H32 272 54 2-Allyl-4-methylphenol 1262 C10H12O 148 55 8,9-Dehydrothymol acetate 1360 C12H14O2 190 56 3,5,5-Trimethyl-4- 1200 C10H14O 150 methylenecyclohex-2-enone 57 Cabreuva oxide D 1467 C15H24O 220 58 p-Isopropylbenzaldehyd 1220 C10H12O 148 59 3-Methyl-4-(2,6,6- 1471 C14H22O 206 trimethylcyclohex-2-enyl)-but-3-en- 2-one 60 2,6,6-Trimethyl-3-oxocyclohex-1- 1110 C10H14O2 166 ene-1-carbaldehyde 61 Isophorone 1100 C9H14O 138 62 3,5,5-Trimethylcyclohex-3-enone 1027 C9H14O 138 63 trans-Sabinyl acetate 1278 C12H16O2 192 64 Nerol 1210 C10H18O 154 65 3a-Hydroxy-1,8-cineol 1217 C10H18O2 170 66 Carvone 1214 C10H14O 150 67 Thymol methyl ether 1215 C11H16O 164 68 Pulegone 1215 C10H16O 152 69 Neral 1215 C10H16O 152 70 p-Anisaldehyde 1218 C8H8O2 136 71 Chavicol 1219 C9H10O 134 72 2,3-Dehydro-1,4-cineol 1219 C10H16O 152 73 trans-Isopulegone 1161 C10H16O 152 74 Piperitone 1226 C10H16O 152 75 1,4-Dimethoxy-2-methylbenzene 1226 C9H12O2 152 76 Carvacrol methyl ether 1226 C11H16O 164 77 Isobornyl formate 1228 C11H18O2 182 78 2-Phenylethyl acetate 1230 C10H12O2 164 79 (E)-Cinnamaldehyde 1234 C9H8O 132 80 2,3-Dehydro-1,8-cineol 993 C10H16O 152 81 2-Hydroxypinan-3-one 1235 C10H16O2 168 82 Geraniol 1235 C10H18O 154 83 Pseudodiosphenol 1245 C10H16O2 168 84 cis-Chrysanthenyl acetate 1253 C12H18O2 194 85 trans-Carvone epoxide 1243 C10H14O2 166 86 cis-Sabinene hydrat acetate 1248 C12H20O2 196 87 cis-Ethyl chrysanthemate 1251 C12H20O2 196 88 trans-Sabinen hydrate acetate 1254 C12H20O2 196 89 Citronellyl formate 1259 C11H20O2 184 90 Perilla aldehyde 1260 C10H14O 150 91 trans-Ethyl chrysanthemate 1260 C12H20O2 196 92 trans-Anethol 1262 C10H12O 148 93 Nonanoic acid 1263 C9H18O2 158 94 Isopulegol acetate (Isomer 1) 1263 C12H20O2 196 95 Methyl nerolate 1265 C11H18O2 182 96 Safrol 1265 C10H10O2 162 97 cis-Thiorose oxide 1265 C10H18S 170 98 cis-Verbenyl acetate 1266 C12H18O2 194 99 Thymol 1267 C10H14O 150 100 Bornyl acetate 1270 C12H20O2 196 101 Neomenthyl acetate 1263 C12H22O2 198 102 Deca-2,4-dienal 1270 C10H16O 152 103 Isopulegol acetate (Isomer 2) 1271 C12H20O2 196 104 2-Undecanone 1273 C10H16O 152 105 4,8-Dimethylnonanol 1276 C11H24O 172 106 Diosphenol 1276 C10H16O2 168 107 Isobornyl acetate 1276 C12H20O2 196 108 Carvacrol 1278 C10H14O 150 109 Thujopsadiene 1470 C15H22 202 110 Sesamol 1280 C7H6O3 138 111 Menthyl acetate 1280 C12H22O2 198 112 Geranial 1244 C10H16O 152 113 Geranyl formate 1284 C11H18O2 182 114 trans-Thiorose oxide 1284 C10H18S 170 115 2-Undecanol 1284 C11H24O 172 116 p-Isopropylbenzyl alcohol 1285 C10H14O 150 117 Sencyunolide 1672 C12H16O2 192 118 trans-Pinocarvyl acetate 1287 C12H18O2 194 119 2,3,6-Trimethylbenzaldehyde 1287 C10H12O 148 120 Terpinen-4-ol acetate 1289 C12H20O2 196 121 Chrysanthenone epoxide 1290 C10H14O2 166 122 (E,E)-Deca-2,4-dienal 1291 C10H16O 152 123 Puleganolide (Isomer 1) 1292 C10H16O2 168 124 Dihydrocarveol acetate (Isomer 2) 1295 C12H20O2 196 125 Isoascaridol 1295 C10H16O2 168 126 Theaspirane (Isomer 1) 1299 C13H22O 194 127 cis-Pinocarvyl acetate 1300 C12H18O2 194 128 Dihydronaginata ketone 1300 C10H14O2 166 129 Naginata ketone alcohol 1306 C10H14O3 182 130 Puleganolide (Isomer 2) 1305 C10H16O2 168 131 Methyl geranate 1306 C11H18O2 182 132 Vinylguaiacol 1311 C9H10O2 150 133 5-Acetoxylinalool 1303 C12H20O3 212 134 Theaspirane (Isomer 2) 1313 C13H22O 194 135 Chavicol acetate 1313 C11H12O2 176 136 Myrtenyl acetate 1313 C12H18O2 194 137 Dihydrocarveol acetate (Isomer 2) 1314 C12H20O2 196 138 Apiol 1649 C12H14O4 222 139 trans-Carvyl acetate 1318 C12H18O2 194 140 Thymol acetate 1329 C12H16O2 192 141 Menthothiophene 1330 C10H14S 166 142 2,3,4-Trimethylbenzaldehyde 1331 C10H12O 148 143 Eugenol 1331 C10H12O2 164 144 cis-Dihydrocarvone epoxide 1333 C10H16O2 168 145 Ethyl nerolat 1335 C12H20O2 196 146 Fragranol 1201 C12H20O2 196 147 7,8-Dihydro-b-ionone 1422 C13H22O 194 148 8-Hydroxylinalool 1336 C10H18O2 170 149 3,4-Dimethoxystyrene 1337 C10H12O2 164 150 Citronellyl acetate 1337 C12H22O2 198 151 trans-8-Mercapto-p-menthan-3-one 1340 C10H18OS 186 152 Anhydroencecalinol 1640 C14H16O2 216 153 Neryl acetate 1342 C12H20O2 196 154 Dihydrocarveol acetate (Isomer 2) 1342 C12H20O2 196 155 exo-Isocamphanyl acetate 1345 C12H20O2 196 156 cis-Carvyl acetate 1345 C12H18O2 194 157 (Z)-Ethyl cinnamate 1344 C11H12O2 176 158 Chavibetol (m-Eugenol) 1346 C10H12O2 164 159 4-Methoxyphenylethanol 1347 C9H12O2 152 160 (E)-Anethol epoxide 1347 C10H12O2 164 161 trans-Dihydrocarvone epoxide 1352 C10H16O2 168 162 endo-Isocamphanyl acetate 1352 C12H20O2 196 163 (E)-Methyl cinnamate 1354 C10H10O2 162 164 cis-8-Mercapto-p-menthan-3-one 1356 C10H18OS 186 165 Dihydrojasmone 1361 C10H14O2 166 166 (E)-b-Damascenone 1363 C13H18O 190 167 3-Allyl-1,4-dimethoxybenzene 1370 C11H14O2 178 168 (Z)-Jasmone 1371 C11H16O 164 169 Isobornyl propionate 1375 C13H22O2 210 170 Ethyl geranate 1377 C12H20O2 196 171 Methyl perillate 1381 C11H16O2 180 172 (Z)-Isoeugenol 1381 C10H12O2 164 173 Osmorhizol 1383 C11H14O2 178 174 2-Dodecanol 1387 C12H26O 186 175 1-Tetradecene 1387 C14H28 196 176 Davanafuran 1394 C14H20O2 220 177 Methyl 4-methoxyphenylacetate 1398 C10H12O3 180 178 (E)-b-Damascone 1398 C13H20O 192 179 trans-Carvyl propionate 1402 C13H20O2 208 180 2,6-Dimethoxycymene 1402 C12H18O2 194 181 Nerylacetone 1412 C13H22O 194 182 2-Hydroxy-1,2-dihydrolavandulyl 1416 C12H22O3 214 acetate 183 (Z)-1,2-Dimethoxy-4- 1419 C11H14O2 178 propenylbenzene 184 (E)-Cinnamyl acetate 1420 C11H12O2 176 185 Isobornyl isobutyrate 1424 C14H24O2 224 186 Citronellyl propionate 1427 C13H24O2 212 187 3,4-Dimethoxybenzaldehyde 1428 C9H10O3 166 188 (E)-Isoeugenol 1429 C10H12O2 164 189 cis-Carvyl propionate 1436 C13H20O2 208 190 Massoialactone 1439 C10H16O2 168 191 d-Undecanolide 1565 C11H20O2 184 192 Nordavanone 1451 C11H18O2 182 193 8-Dehydrothymol isobutyrate 1458 C14H18O2 218 194 (E)-1,2-Dimethoxy-4- 1460 C11H14O2 178 propenylbenzene 195 Thymol isobutyrate 1462 C14H20O2 220 196 Isobornyl butyrate 1462 C14H24O2 224 197 3,4-Dimethoxybenzyl alcohol 1464 C9H12O3 168 198 Sarisane 1466 C11H12O3 192 199 2-Tridecanone 1477 C13H26O 198 200 2-Tridecanol 1490 C13H28O 200 201 Davana ether 1489 C15H22O2 234 202 a-Campholenyl formate 1240 C11H18O2 182 203 Chavibetyl acetate 1488 C12H14O3 206 204 Homovanilline alcohol 1494 C9H12O3 168 205 Davana ether (Isomer) 1507 C15H22O2 234 206 Isobornyl isovalerate 1516 C15H26O2 238 207 Citronellyl butyrate 1516 C14H26O2 226 208 Elemicine 1522 C12H16O3 208 209 Flavesone 1526 C14H20O4 252 210 allo-Davanone 1539 C15H24O2 236 211 Isodavanone 1545 C15H24O2 236 212 Eupatoriochromene 1726 C13H16O3 220 213 cis-Davanone 1557 C15H24O2 236 214 Geranyl crotonate 1555 C14H22O2 222 215 Diethylphthalate 1555 C12H14O4 222 216 cis-8-Acetylthio-p-menthan-3-one 1559 C12H20O2S 228 217 4-Allyl-2,6-dimethoxyphenol 1561 C11H14O3 194 218 Sandela 1568 C16H28O 236 219 trans-8-Acetylthio-p-mentan-3-one 1570 C12H20O2S 228 220 (Z)-Asarone 1584 C12H16O3 208 221 (Z)-3-Hexenyl benzoate 1545 C13H16O2 204 222 Geranyl 2-methylbutyrate 1591 C15H26O2 238 223 1,2-Diacetoxy-4-allylbenzene 1602 C13H14O4 234 224 Leptospermone 1611 C15H22O4 266 225 (Z)-Ethyl p-methoxycinnamate 1614 C12H14O3 206 226 Butylphthalide 1616 C12H14O2 190 227 (E)-Asarone 1636 C12H16O3 208 228 (Z)-Butylidenphthalide 1644 C12H12O2 188 229 6-Methoxythymol isobutyrate 1658 C15H22O3 250 230 2-Pentadecanone 1688 C15H30O 226 231 (E)-Ethyl p-methoxycinnamate 1711 C12H14O3 206 232 (Z)-Ligustilide 1732 C12H14O2 190 233 Heyderiol 2374 C22H30O4 358 234 (E)-Ligustilide 1782 C12H14O2 190 235 7,11-Dimethylheptadecane 1792 C19H40 268 236 Avocadynofuran 1796 C17H26O 246 237 Galaxolide 1838 C18H26O 258 238 Traseolide 1840 C18H26O 258 239 Tonalide 1850 C18H26O 258 240 1-Nonadecene 1875 C19H38 266 241 Nonadecane 1900 C19H40 268 242 Falcarinol 2028 C17H24O 244 243 Trichocoleine 1875 C14H18O4 250 244 Ambrettolide 1905 C16H28O2 252 245 Methyl 4-Hydroxy-3-methoxy-5- 1833 C14H18O4 250 (1,1-dimethylprop-2-enyl)-benzoate 246 (E)-Benzyl cinnamate 2023 C16H14O2 238 247 trans-Pinocarvyl formate 1228 C11H16O2 180 248 Hex-5-en-1-ol 820 C6H12O 100 249 Hex-5-en-3-ol 832 C6H12O 100 250 1-Hexanol 837 C6H14O 102 251 (Z)-Hex-3-en-1-ol 851 C6H12O 100 252 (E)-Hex-3-en-1-ol 851 C6H12O 100 253 (Z)-Hex-2-en-1-ol 861 C6H12O 100 254 2-Heptanone 871 C7H14O 114 255 2-Heptanol 880 C7H16O 116 256 3-Heptanol 877 C7H16O 116 257 n-Heptanal 882 C7H14O 114 258 Santene 884 C9H14 122 259 2-Methyl-1-hexanol 917 C7H16O 116 260 Tricyclene 927 C10H16 136 261 a-Pinene 936 C10H16 136 262 Benzaldehyde 941 C7H6O 106 263 a-Fenchene 941 C10H16 136 264 Thuja-2,4(10)-diene 946 C10H14 134 265 6-Methyl-2-heptanol 950 C8H18O 130 266 Camphene 950 C10H16 136 267 1-Octen-3-ol 962 C8H16O 128 268 3-Octanone 969 C8H16O 128 269 4-Octanol 973 C8H18O 130 270 2-Octanol 981 C8H18O 130 271 3-Octanol 981 C8H18O 130 272 2-Pentylfuran 981 C9H14O 138 273 Yomogialcohol 991 C10H18O 154 274 3,6-Dimethyl-3-heptanol 990 C9H20O 144 275 D 2-Carene 1000 C10H16 136 276 a-Phellandrene 1002 C10H16 136 277 (Z)-Hex-3-enyl acetate 1002 C8H14O2 142 278 p-Methylanisol 1004 C8H10O 122 279 Benzyl alcohol 1006 C7H8O 108 280 D 3-Carene 1010 C10H16 136 281 Phenylacetaldehyde 1012 C8H8O 120 282 m-Cymene 1013 C10H14 134 283 p-Cymene 1015 C10H14 134 284 Salicylaldehyde 1020 C7H6O2 122 285 Limonene 1025 C10H16 136 286 1,8-Cineol 1024 C10H18O 154 287 (Z)-b-Ocimene 1029 C10H16 136 288 (E)-2-Octenal 1034 C8H14O 126 289 5,5-Dimethylbut-3-enolide 916 C6H8O2 112 290 Methyl 3-methylfuroate 1038 C7H8O3 140 291 (E)-b-Ocimene 1041 C10H16 136 292 Oct-3-en-1-ol (Isomer 1) 1044 C8H16O 128 293 Artemisia ketone 1044 C10H16O 152 294 cis-Dihydroroseoxide 1047 C10H20O 156 295 d-Terpineol 1155 C10H16O 152 296 g-Terpinene 1051 C10H16 136 297 trans-Sabinene hydrate 1053 C10H18O 154 298 Dihydromyrcenol 1058 C10H20O 156 299 Non-1-en-3-ol 1058 C9H18O 142 300 trans-Linalooloxide (furanoid) 1058 C10H20O2 172 301 p-Mentha-3,8-diene 1059 C10H16 136 302 Benzyl formate 1060 C8H8O2 136 303 m-Cresol 1061 C7H8O 108 304 p-Cresol 1062 C7H8O 108 305 1-Octanol 1063 C8H18O 130 306 Fenchone 1069 C10H16O 152 307 o-Guiacol 1072 C7H8O2 124 308 Methyl benzoate 1072 C8H8O2 136 309 cis-Linalool oxide (furanoid) 1072 C10H18O2 170 310 Artemisia alcohol 1073 C10H18O 154 311 Dehydrolinalool 1073 C10H16O 152 312 trans-Dihydroroseoxide 1075 C10H20O 156 313 4-Nonanol 1076 C9H20O 144 314 Terpinolene 1082 C10H16 136 315 cis-Sabinene hydrate 1082 C10H18O 154 316 2-Nonanol 1085 C9H20O 144 317 Linalool 1086 C10H18O 154 318 Photocitral B 1086 C10H16O 152 319 a-Thujone 1089 C10H16O 152 320 2,2′,5,6-Tetramethylcyclohexanone 1092 C10H18O 154 (Isomer 1) 321 1-Oct-3-enyl acetate 1093 C10H18O2 170 322 4,8-Dimethyl-1,3,7-nonatriene 1096 C11H18 150 (Isomer 1) 323 a-Pinene epoxide (Isomer 1) 1096 C10H16O 152 324 a-Fenchol 1099 C10H18O 154 325 cis-Rose oxide 1100 C10H18O 154 326 Isochrysanthenone 1086 C10H14O 150 327 b-Thujone 1103 C10H16O 152 328 a-Campholenal 1105 C10H16O 152 329 2,2′,5,6-Tetramethylcyclohexanone 1106 C10H18O 154 (Isomer 2) 330 2-Methyl-5-propionylfuran 1108 C8H10O2 138 331 cis-p-Menth-2-en-1-ol 1108 C10H18O 154 332 (Z)-Ocimenoxide 1115 C10H16O 152 333 4,8-Dimethylnona-1,3,7-triene 1115 C11H18 150 (Isomer 2) 334 a-Pinene epoxide (Isomer 2) 1116 C10H16O 152 335 trans-Rose oxide 1116 C10H18O 154 336 Dihydrolinalool 1118 C10H20O 156 337 Ipsdienol 1123 C10H16O 152 338 Camphor 1123 C10H16O 152 339 trans-p-Menth-2-en-1-ol 1123 C10H18O 154 340 (E)-Ocimenoxide 1125 C10H16O 152 341 p-Mentha-1,5-diene-8-ol 1127 C10H16O 152 342 trans-Pinocarveol 1126 C10H16O 152 343 cis-Limonene oxide 1126 C10H16O 152 344 Photocitral A 1127 C10H16O 152 345 o-Cymenene 1076 C10H12 132 346 (E)-Tagetone 1128 C10H16O 152 347 (Z)-Tagetone 1136 C10H16O 152 348 trans-Limonene oxide 1130 C10H16O 152 349 Isopulegol 1132 C10H18O 154 350 1,3-Dimethoxybenzene 1136 C8H10O2 138 351 Menthone 1136 C10H18O 154 352 Pinocarvone 1137 C10H14O 150 353 b-Terpineol 1137 C10H18O 154 354 (E)-Non-2-enal 1139 C9H16O 140 355 Isoneral 1140 C10H16O 152 356 cis-b-Terpineol 1141 C10H18O 154 357 Isoborneol 1142 C10H18O 154 358 Karahanaenone 1142 C10H16O 152 359 cis- or trans-Linalool oxide 1144 C10H18O2 170 (pyranoid) 360 Isomenthone 1146 C10H18O 154 361 cis-Chrysanthenol 1147 C10H16O 152 362 2-Hydroxyethyl-4-methylbenzene 1147 C9H12O 136 363 4-Isopropylcyclohexanone 1148 C9H16O 140 364 cis- or trans-Linalool oxide 1148 C10H18O2 170 (pyranoid) 365 cis-Isopulegone 1148 C10H16O 152 366 Methyl phenylacetate 1148 C9H10O2 150 367 cis-Thujol 1149 C10H18O 154 368 b-Pinene epoxide 1149 C10H16O 152 369 Ethyl benzoate 1150 C9H10O2 150 370 Borneol 1150 C10H18O 154 371 Lavandulol 1150 C10H18O 154 372 Umbellulone 1152 C10H14O 150 373 trans-Chrysanthemol 1153 C10H18O 154 374 Neomenthol 1156 C10H20O 156 375 Viridene 1159 C10H12O 148 376 Isogeranial 1156 C10H16O 152 377 cis-Chrysanthemol 1157 C10H18O 154 378 Benzoic acid 1160 C7H6O2 122 379 3-Thujene-10-al 1158 C10H14O 150 380 Cryptone 1160 C9H14O 138 381 Terpinen-4-ol 1164 C10H18O 154 382 b-Pinene epoxide (Isomer) 1170 C10H16O 152 383 Nona-2,4-dienal 1170 C9H14O 138 384 Methyl salicylate 1171 C8H8O3 152 385 2-Methyl-2-borneol 1175 C11H20O 168 386 2-Allylphenol 1174 C9H10O 134 387 Thujopsa-3-one 1645 C15H24O 220 388 7-Hydroxyhotrienol 1177 C10H18O2 170 389 Myrtenol 1178 C10H16O 152 390 cis-Piperitol 1181 C10H18O 154 391 Safranal 1182 C10H14O 150 392 Estragol (Methylchavicol) 1175 C10H12O 148 393 2-Decanol 1188 C10H22O 158 394 g-Terpineol 1188 C10H18O 154 395 (E,E)-Nona-2,4-dienal 1188 C9H14O 138 396 Methyl a-cyclogeranate 1190 C11H18O2 182 397 trans-Piperitol 1193 C10H18O 154 398 Chrysanthenone 1110 C10H14O 150 399 Fenchyl acetate 1205 C12H20O2 196 400 Benzylacetone 1207 C10H12O 148 401 2-epi-Thujopsa-3-one 1634 C15H24O 220 402 Carvotanacetone 1220 C10H16O 152 403 Menthol 1172 C10H20O 156 404 Isomenthol 1176 C10H20O 156 405 a-Terpinyl acetate 1335 C10H16 136 406 Octyl acetate 1188 C10H20O2 172 407 Dillether 1170 C10H16O 152 408 (E)-Ethyl cinnamate 1439 C11H12O2 176 409 b-Ionone 1468 C13H20O 192 410 Piperonal 1294 C8H6O3 150 411 Vanilline 1355 C8H8O3 152 412 Coumarin 1392 C9H6O2 146 413 (Z)-2-Hexylcinnamic aldehyde 1725 C15H20O 216 414 1-Phenylethyl acetate 1166 C10H12O2 164 415 (Z)-2-Pentylcinnamaldehyde 1632 C14H18O 202 416 Benzyl salicylate 1847 C14H12O3 228 417 Menthofuran 1150 C10H14O 150 418 a-Campholenol 1190 C10H18O 154 419 Methyl jasmonate 1611 C13H20O3 224 420 Isophytol 1949 C20H40O 296 421 Phytol 2114 C20H40O 296 422 (E)-Anyl 2-methylbutyrate 1651 C14H18O2 218 423 (E)-4-4Propenylphenol tiglate 1765 C14H16O2 216 424 trans-Epoxypseudoisoeugenyl-2- 1871 C15H20O4 264 methylbutyrate 425 (E)-Pseudoisoeugenyl tiglate 1895 C15H18O3 246 426 trans-Epoxypseudoisoeugenol tiglate 1942 C15H18O4 262 427 Dictyotene 1155 C11H18 150 428 Desmarestene 1168 C11H14 146 429 Dictyopterene A 1099 C11H18 150 430 Ectocarpene 1136 C11H16 148 431 (E)-Ectocarpene 1147 C11H16 148 432 cis-Hormosirene 1152 C11H16 148 433 trans-Hormosirene 1160 C11H16 148 434 (Z)-Multifidene 1040 C11H16 148 435 (E)-Multifidene 1047 C11H16 148 436 (E)-Aucantene 1062 C11H16 148 437 (E)-Aucantene 1077 C11H16 148 438 cis-Dihydromultifidene 1052 C11H18 150 439 trans-Dihydromultifidene 1058 C11H18 150 440 Neothujol 1136 C10H16O 152 441 (Z)-Methyl cinnamate 1270 C10H10O2 162 442 Isothujol 1121 C10H16O 152 443 Neoisothujol 1132 C10H16O 152 444 Citronellal 1129 C10H18O 154 445 2-Methyl-2-pentanol 944 C6H14O 102 446 6-Acetoxy-p-mentha-1(7),8-diene 1312 C12H18O2 194 (Isomer 1) 447 n-Nonanal 1076 C9H18O 142 448 5,7-Dimethylocta-1,6-diene 911 C10H18 138 449 Dec-9-en-1-ol 1240 C10H20O 156 450 Elsholtzia ketone 1175 C10H14O2 166 451 a-Dehydroelsholtzia ketone 1188 C10H12O2 164 452 Dehydroelsholtzia ketone 1277 C10H12O2 164 453 4-Methyl-3-heptanol 956 C8H18O 130 454 6-Methylhept-5-en-2-ol (Sulcatol) 981 C8H16O 128 455 b-Helmiscapene 1446 C15H24 204 456 2,2-Dimethyl-4-oxocyclohexane-1- 1132 C9H14O2 154 carbaldehyde 457 Menth-1-en-9-ol 1283 C10H18O 154 458 cis-Dihydrocarvone 1172 C10H16O 152 459 trans-Dihydrocarvone 1177 C10H16O 152 460 Limonen-10-ol 1272 C10H16O 152 461 Tuberolactone 1437 C10H14O2 166 462 trans-Carveol 1200 C10H16O 152 463 Dihydrocarveol (Isomer 1) 1176 C10H18O 154 464 Dihydrocarveol (Isomer 2) 1193 C10H18O 154 465 Dihydrocarveol (Isomer 3) 1205 C10H18O 154 466 cis-Carveol 1210 C10H16O 152 467 4-Methoxyphenylacetone 1343 C10H12O2 164 468 4-Methoxypropiophenone 1415 C10H12O2 164 469 Grandisol 1200 C10H18O 154 470 Hotrienol 1083 C10H16O 152 471 Isopinocampheol 1168 C10H16O 152 472 (E)-Pseudoisoeugenyl-2-methyl 1823 C15H20O3 248 butyrate 473 Falcarinone 1990 C17H22O 242 474 Ethyl salicylate 1245 C9H10O3 166 475 1,2-Dihydro-1,1,6-trimethyl- 1339 C13H16 172 naphthalene 476 g-Hexanolide 1006 C6H10O2 114 477 g-Heptanolide 1103 C7H12O2 128 478 g-Octanolide 1208 C8H14O2 142 479 g-Nonanolide 1318 C9H16O2 156 480 g-Decanolide 1433 C10H18O2 170 481 g-Undecanolide 1547 C11H20O2 184 482 g-Dodecanolide 1656 C12H22O2 198 483 g-Tetradecanolide 1866 C14H26O2 226 484 d-Nonanolide 1348 C9H16O2 156 485 d-Octanolide 1240 C8H14O2 142 486 d-Heptanolide 1156 C7H12O2 128 487 d-Decanolide 1461 C10H18O2 170 488 (E)-a-Damascone 1375 C13H20O 192 489 4-Methyl-3-heptanone 918 C8H16O 128 490 a-Ionone 1409 C13H20O 192 491 p-Methylacetophenone 1156 C9H10O 134 492 b-Cyclocitral 1195 C10H16O 152 493 cis-a-Irone 1520 C14H22O 206 494 cis-g-Irone 1525 C14H22O 206 495 Dodecanal 1389 C12H24O 184 496 Methyl linolenate 2102 C19H32O2 292 497 Geranylacetone 1430 C13H22O 194 498 trans-Isolimonene 975 C10H16 136 499 cis-Myrtanol 1238 C10H18O 154 500 n-Octanal 981 C8H16O 128 501 p-Menth-1-ene 1017 C15H18 198 502 (E)-Jasmone 1356 C11H16O 164 503 trans-Myrtanol 1240 C10H18O 154 504 allo-Ocimene 1113 C10H16 136 505 (4E,6Z)-allo-Ocimene 1126 C10H16 136 506 Dodecanol 1472 C12H26O 186 507 6-Acetoxy-p-menta-1,8-diene 1341 C12H18O2 194 508 b-Citronellene 943 C15H18 198 509 n-Nonanol 1149 C9H20O 144 510 trans-Sabinol 1120 C10H16O 152 511 3,5-Dimethoxytoluene 1231 C9H12O2 152 512 Phantolide 1712 C17H24O 244 513 Perilla alcohol 1280 C10H16O 152 514 b-Phellandrene 1023 C10H16 136 515 b-Phenylethanol 1085 C8H10O 122 516 Citronellol 1213 C10H20O 156 517 Methyleugenol 1369 C11H14O2 178 518 2-Nonanone 1074 C9H18O 142 519 2-Decanone 1176 C10H20O 156 520 2-Dodecanone 1381 C12H24O 184 521 4-Isopropylcyclohexanol (Isomer 2) 1130 C9H18O 142 522 Moskachane B 1794 C13H16O3 220 523 Moskachane D 2001 C15H20O3 248 524 cis-Verbenol 1132 C10H16O 152 525 (Z)-Salvene 849 C9H16 124 526 (E)-Salvene 859 C9H16 124 527 Santolinatriene 909 C10H16 136 528 a-Thujene 932 C10H16 136 529 Sabinene 973 C10H16 136 530 a-Terpinene 1013 C10H16 136 531 trans-Verbenol 1136 C10H14O 150 532 Verbenone 1183 C10H14O 150 533 Z-Cinnamaldehyde 1185 C9H8O 132 534 3-Phenylpropanol 1201 C9H12O 136 535 (E)-Cinnamyl alcohol 1275 C9H10O 134 536 b-Irone 1566 C14H22O 206 537 Benzyl acetate 1134 C9H10O2 150 538 Indole 1257 C8H7N 117 539 d-Jasmolactone 1450 C10H16O2 168 540 N-Acetyl methyl anthranilate 1565 C10H11O3N 193 541 Benzyl benzoate 1730 C14H12O2 212 542 6-Methylhept-5-en-2-one 978 C8H14O 126 543 Rosefuran 1091 C10H14O 150 544 Rosefuran epoxide 1161 C10H14O2 166 545 b-Pinene 978 C10H16 136 546 Myrcene 987 C10H16 136 547 Oct-3-en-1-ol (Isomer 2) 1049 C8H16O 128 548 6-Acetoxy-p-mentha-1(7),8-diene 1343 C12H18O2 194 (Isomer 2) 549 (E)-4-Propenylphenol angelate 1751 C14H16O2 216 550 cis-Epoxypseudoisoeugenyl-2- 1870 C15H20O4 264 methyl butyrate 551 Myrtenal 1172 C10H14O 150 552 (E)-Ocimenone 1219 C10H14O 150 553 (Z)-Ocimenone 1209 C10H14O 150 554 Isomenthyl acetate 1298 C12H22O2 198 555 Thymoquinone 1215 C10H12O2 164 556 Cymen-9-ol 1157 C10H14O 150 557 8,9-Dehydrothymol 1190 C10H12O 148 558 (Z)-Methyl p-hydroxycinnamate 1603 C10H10O3 178 559 b-Thujaplicine 1449 C10H12O2 164 560 n-Undecane 1100 C11H24 156 561 n-Nonane 906 C9H20 128 562 Pinocamphone 1139 C10H16O 152 563 Isopinocamphone 1151 C10H16O 152 564 Methyl 2-methylbutyrate 954 C6H12O2 116 565 6-Methylhept-5-enal 985 C8H14O 126 566 Furomyrcenol 1256 C10H14O2 166 567 a-Ionone epoxide (Isomer 1) 1516 C13H20O2 208 568 o-Cresol 1037 C7H8O 108 569 (E)-2-Hexenal 832 C6H10O 98 570 Ethyl 2-methylbutyrate 843 C7H14O2 130 571 p-Mentha-2,4(8)-diene 1077 C10H16 136 572 p-Mentha-1,3,8-triene 1101 C10H16 136 573 Neroloxide 1137 C10H16O 152 574 Neoisopulegol 1150 C10H18O 154 575 (E,E)-Nona-3,6-dien-1-ol 1145 C9H16O 140 576 n-Pentylbenzene 1150 C11H16 148 577 (Z)-Ethyl oct-5-enoate 1174 C10H18O2 170 578 a-Terpineol 1176 C10H18O 154 579 2a-Hydroxy-1,8-cineol 1196 C10H18O2 170 580 cis-Pulegol 1215 C10H18O 154 581 3b-Hydroxy-1,8-cineol 1229 C10H18O2 170 582 Linalyl acetate 1239 C12H20O2 196 583 Isopiperitenone 1240 C10H14O 150 584 Piperitenone 1318 C10H14O 150 585 Piperitenone oxide 1335 C10H14O2 166 586 Geranyl acetate 1362 C12H20O2 196 587 2-Methylbutyl benzoate 1419 C12H16O2 192 588 Myristicine 1489 C11H12O3 192 589 Acetophenone 1036 C8H8O 120 590 Dihydrotagetone 1047 C10H18O 154 591 p-Cymenene 1075 C10H12 132 592 Piperiton epoxid 1232 C10H16O2 168 593 Nepetalacton (Isomer 2) 1360 C10H14O2 166 594 3,4-Dimethyl-5-pentyl-5H-furan-2- 1481 C11H18O2 182 one 595 Methyl p-methoxybenzoate 1338 C9H10O3 166 596 (E)-o-Methoxycinnamyl alcohol 1488 C10H12O2 164 597 (E)-m-Methoxycinnamyl alcohol 1511 C10H12O2 164 598 (E)-p-Methoxycinnamyl alcohol 1523 C10H12O2 164 599 Perillene 1090 C10H14O 150 600 Methyl anthranilate 1308 C8H9O2N 151 601 1-(3-Methoxyphenyl)-2- 1735 C15H16O 212 phenylethane 602 1-Phenyl-2-(3,5-dimethoxyphenyl)- 1962 C16H18O2 242 ethane 603 1-(3-Methoxyphenyl)-2-(4- 1988 C16H18O2 242 methoxyphenyl)-ethane 604 Neryl isobutyrate 1468 C14H24O2 224 605 Zingiberenol 1596 C14H24O 208 606 Encecalin 1813 C14H16O3 232 607 Ethyl p-methoxybenzoate 1415 C10H12O3 180 608 Albanone 1389 C12H18O 178 609 7,10-Anhydro-11,12- 1449 C15H24O 220 dihydrochiloscypholone 610 1(11)-Africanen-8-ol 1486 C15H24O 220 611 Atractylone 1497 C15H20O 216 612 Conocephalenol 1497 C15H26O 222 613 Cubebol 1514 C15H26O 222 614 Photosantalol 1511 C15H24O 220 615 Cyperene epoxide 1524 C15H24O 220 616 Isoafricanol 1529 C15H26O 222 617 cis-Cadina-4,6-dien-11-ol 1531 C15H24O 220 618 Elema-1,3-dien-7-ol 1531 C15H24O 220 619 Tamariscol 1535 C15H26O 222 620 Pacifigorgiol 1539 C15H26O 222 621 (E,E)-Methyl 10-oxofarnesoate 1896 C16H26O3 266 622 b-Caryophyllene oxide 1546 C15H24O 220 623 Africanone 1547 C15H22O 218 624 1,8-Oxidocadin-4-ene 1551 C15H24O 220 625 4bH,5aH-cis-Eudesm-6-en-11-ol 1555 C15H26O 222 626 Dactylol 1556 C15H26O 222 627 cis-Sesquisabinenhydrate 1558 C15H26O 222 628 11,12-Dihydrochiloscyphone 1558 C15H24O 220 629 Aromadendran-5-ol 1562 C15H26O 222 630 Oxidohimachalene 1557 C15H22O 218 631 (+)-Marsupellol 1564 C15H24O 220 632 b-Himachalol 1638 C15H26O 222 633 Maaliol 1565 C15H26O 222 634 Deoxopinguisone 1563 C15H22O 218 635 Palustrol 1569 C15H26O 222 636 4a-Hydroxygermacra-1(10),5-diene 1571 C15H26O 222 637 Spathulenol 1572 C15H24O 220 638 4-Dehydroviridiflorol 1572 C15H24O 220 639 Caryophyllene oxide 1578 C15H24O 220 640 7-Acetoxyelema-1,3,8-triene 1584 C17H26O2 262 641 Globulol 1589 C15H26O 222 642 Cubeban-11-ol 1591 C15H26O 222 643 Salvial-4(14)-en-1-one 1592 C15H24O 220 644 Bisabola-2,10-diene 1,9-oxide 1592 C15H24O 220 645 b-Oplopenone 1595 C15H24O 220 646 Longiborneol 1597 C15H26O 222 647 Rosifoliol 1599 C15H26O 222 648 Ledol 1600 C15H26O 222 649 2-Methyl-1-(octahydro-7,7a- 1601 C15H26O 222 dimethyl-1H-inden-1-yl)-propan-1- one 650 Eudesm-4-en-7-ol 1604 C15H26O 222 651 Rearrangement product from 1608 C15H22O 218 Grimaldone 652 Maalian-5-ol 1607 C15H26O 222 653 10-epi-g-Eudesmol 1609 C15H26O 222 654 ar-Curcumen-7-ol 1610 C15H22O 218 655 Amorpha-4,7-dien-11-ol 1610 C15H24O 220 656 5-Guaiene-11-ol 1619 C15H26O 222 657 g-Eudesmol 1618 C15H26O 222 658 Alismol 1619 C15H24O 220 659 Gymnomitrone 1620 C15H22O 218 660 Isospathulenol 1625 C15H24O 220 661 Isogymnomitrol 1625 C15H24O 220 662 Furanoeudesm-1,3-diene 1630 C15H18O 214 663 Amorpha-4-en-7-ol 1629 C15H26O 222 664 Eudesm-3,11-dien-5-ol 1632 C15H24O 220 665 Hinesol 1632 C15H26O 222 666 T-Muurolol 1633 C15H26O 222 667 (E,E)-Germacradiene-11-ol 1633 C15H26O 222 668 T-Cadinol 1633 C15H26O 222 669 Gymnomitr-3(15)-en-4-one 1635 C15H22O 218 670 1(10)-Spirovetivene-7b-ol 1636 C15H26O 222 671 Muurola-3,7(11)-dien-1-ol 1637 C15H24O 220 672 6-Himachalen-9b-ol 1638 C15H26O 222 673 Gymnomitran-4-one 1639 C15H24O 220 674 b-Eudesmol 1641 C15H26O 222 675 Furanoeremophilene 1642 C15H22O 218 676 2-Himachalen-7b-ol 1642 C15H26O 222 677 a-Cadinol 1643 C15H26O 222 678 Eudesm-4(15)-en-7-ol 1643 C15H24O 220 679 2-Methyl-1-(octahydro-7,7a- 1645 C15H28O 224 dimethyl-1H-inden-1-yl)-propan-1- ol 680 Eudesm-11-en-4a-ol 1649 C15H26O 222 681 1(10)-Valencen-7b-ol 1646 C15H26O 222 682 Valerianol 1647 C15H26O 222 683 Eudesm-3-en-7-ol 1650 C15H26O 222 684 10-epi-trans-Dracunculifoliol 1591 C15H26O 222 685 7-epi-a-Eudesmol 1653 C15H26O 222 686 Acorenol B 1654 C15H26O 222 687 Bisabolol oxide B 1654 C15H26O2 238 688 Aromadendran-12-ol 1654 C15H24O 220 689 Grimaldone 1656 C15H22O 218 690 Gymnomitrol 1657 C15H24O 220 691 Eudesm-4(15)-en-6-ol 1656 C15H26O 222 692 Saccogynol 1660 C15H22O 218 693 Valeranone 1664 C15H26O 222 694 4-epi-Acorenone 1664 C15H24O 220 695 Gymnomitr-3(15)-en-4a-ol 1665 C15H24O 220 696 Acorenol 1667 C15H26O 222 697 epi-Cyclosantalal 1668 C15H24O 220 698 (Z)-g-Atlantone 1669 C15H22O 218 699 a-Alasken-6-ol 1674 C15H24O 220 700 Bisabolone oxide A 1675 C15H24O2 236 701 Amorpha-4,7(11)-dien-8-one 1679 C15H22O 218 702 Amorpha-4,9-dien-2-ol 1679 C15H24O 220 703 Amorpha-4,9-dien-14-al 1685 C15H22O 218 704 Eudesm-3-en-6-ol 1679 C15H26O 222 705 Khusiol 1680 C15H26O 222 706 (E)-g-Atlantone 1681 C15H22O 218 707 Acorenone 1681 C15H24O 220 708 Cadina-1(10),4-dien-8a-ol 1682 C15H24O 220 709 Bicyclogermacren-14-al 1684 C15H22O 218 710 Cyperotundone 1684 C15H22O 218 711 (Z)-a-Atlantone 1689 C15H22O 218 712 Lanceol oxide 1695 C15H24O 220 713 Farnesol (Isomer 1) 1694 C15H26O 222 714 6a-Hydroxygermacra-1(10),4-diene 1687 C15H26O 222 715 Acora-7(11),9-dien-2-one 1706 C15H22O 218 716 Valerenal 1706 C15H22O 218 717 a-Herbertenol 1711 C15H22O 218 718 Dihydrochiloscypholone 1711 C15H26O2 238 719 Italicen-4-one 1717 C15H22O 218 720 Farnesol (Isomer 2) 1718 C15H26O 222 721 10-epi-1,8-Oxidocadina-4-ene 1539 C15H24O 220 722 Neopetasone 1733 C15H22O 218 723 7,14-Anhydroamorpha-4,9-diene 1733 C15H22O 218 724 Lepidozenal 1744 C15H22O 218 725 7-Acetoxyelema-1,3-dien-8-ol 1793 C17H28O3 280 726 Naviculol 1734 C15H26O 222 727 Bisabolol oxide A 1740 C15H26O2 238 728 a-Cyperone 1741 C15H22O 218 729 Cyclocolorenone 1745 C15H22O 218 730 Gymnomitrol acetate 1751 C17H26O2 262 731 b-Herbertenol 1751 C15H22O 218 732 (E)-a-Atlantone 1754 C15H22O 218 733 (Z)-Lanceol 1755 C15H24O 220 734 Cuparophenol 1763 C15H22O 218 735 Cedryl acetate 1764 C17H28O2 264 736 14-Oxocalamenene 1768 C15H20O 216 737 Isovalencenol 1779 C15H24O 220 738 Drimenol 1750 C15H26O 222 739 cis-5-Hydroxycalamenene 1790 C15H22O 218 740 Khusienol acetate 1789 C17H26O2 262 741 Fukinanolide 1798 C15H22O2 234 742 Bisabola-2,7(Z),10(Z)-triene-13-ol 1806 C15H24O 220 743 Cyperadione 1820 C15H24O2 236 744 cis-Spiroether 1850 C13H12O2 200 745 trans-Spiroether 1853 C13H12O2 200 746 trans-4,8a-Dimethyl-4a,5- 1350 C12H20O 180 epoxydecaline 747 Peculiaroxide 1416 C15H26O 222 748 Furanoelemene 1485 C15H20O 216 749 Guaioxide 1487 C15H26O 222 750 Elemol 1541 C15H26O 222 751 Lemnalol 1579 C15H24O 220 752 Fokienol 1582 C15H24O 220 753 Thujopsane-2b-ol 1593 C15H26O 222 754 a-Alasken-8-ol 1600 C15H24O 220 755 6-epi-Cubenol 1602 C15H26O 222 756 Widdrol 1601 C15H26O 222 757 Marsupellone 1604 C15H22O 218 758 Axinyssene 1860 C20H32 272 759 Selina-1,3,7(11)-trien-8-one 1616 C15H20O 216 760 Myliol 1617 C15H22O 218 761 a-Acorenol 1623 C15H26O 222 762 Furanogermacrene 1624 C15H20O 216 763 Acora-3,7(11)-dien-6-ol 1626 C15H24O 220 764 b-Acorenol 1626 C15H26O 222 765 a-Alaskene-8-ol 1632 C15H24O 220 766 Microbiotol 1632 C15H26O 222 767 Isopinguisanine 1638 C15H20O2 232 768 Gymnomitr-3(15)-en-4b-ol 1653 C15H24O 220 769 a-Eudesmol 1653 C15H26O 222 770 Isorotundenol 1659 C15H26O 222 771 Bulnesol 1665 C15H26O 222 772 Bicyclohumulenone 1668 C15H24O 220 773 Selina-4(15),11-dien-8-ol 1670 C15H24O 220 774 Smyrnicordifuran 1673 C15H18O2 230 775 b-Sinensal 1675 C15H22O 218 776 Isocyperol 1676 C15H24O 220 777 a-Cuparenone 1681 C15H20O 216 778 Cyperol 1681 C15H24O 220 779 Gymnomitr-3-en-15-ol 1688 C15H24O 220 780 Pinguisanine 1706 C15H20O2 232 781 Acora-3,7(11)-dien-8-one 1709 C15H22O 218 782 Vetiselinol 1709 C15H24O 220 783 10,11-Dihydro-a-cuparenone 1712 C15H22O 218 784 Oxidoselina-1,3,7(11)-trien-8-one 1725 C15H20O2 232 785 a-Sinensal 1726 C15H22O 218 786 Plagiochilide 1729 C15H20O2 232 787 (E,E)-Methyl 10,11-epoxyfarnesoate 1875 C16H26O3 266 788 Eudesma-3,11-dien-2-one 1776 C15H22O 218 789 Zizaenic acid 1791 C15H22O2 234 790 Acutifolene B 1806 C15H20O3 248 791 a-Vetivone 1821 C15H22O 218 792 (E,E)-Farnesylacetate 1822 C17H28O2 264 793 Acutifolene A 1833 C16H22O3 262 794 Furanoeremophilone 1855 C15H20O2 232 795 2-Acetoxyfuranoelemene 1876 C17H22O3 274 796 Guaia-3,10(14)-dien-6,12-olide 1938 C15H20O2 232 797 Guaia-3,7(11),10(14)-trien-6,12- 1950 C15H18O2 230 olide 798 1b-Acetoxyfurano-4(15)-eudesmene 1964 C17H22O3 274 799 1b-Acetoxyfurano-3-eudesmene 1978 C17H22O3 274 800 Maalioxide 1508 C15H26O 222 801 Kessane 1533 C15H26O 222 802 Humulene epoxide 3 1626 C15H24O 220 803 8-Hydroxybicyclogermacrene 1661 C15H24O 220 804 Lactarovioline 2068 C15H14O 210 805 5-epi-Pinguisenol 1764 C15H26O 222 806 b-Santalol acetate 1800 C17H26O2 262 807 Bisacumol (Isomer 1) 1596 C15H22O 218 808 Bisacumol (Isomer 2) 1619 C15H22O 218 809 Bisabola-1,3(15),10-trien-9-ol 1666 C15H24O 220 (Isomer 1) 810 Bisabola-1,3(15),10-trien-9-ol 1678 C15H24O 220 (Isomer 2) 811 trans-Sesquisabinen hydrate 1564 C15H26O 222 812 1bH-Presilphiperfolane-9a-ol 1510 C15H26O 222 813 1aH-Presilphiperfolan-9b-ol 1499 C15H26O 222 814 Presilphiperfolane-9a-ol 1519 C15H26O 222 815 ar-Curcumen-15-al 1681 C15H20O 216 816 Sesquicineol 1507 C15H26O 222 817 Italicen-13-al 1671 C15H22O 218 818 a-Copaen-8-ol 1551 C15H24O 220 819 Khusimol 1720 C15H24O 220 820 Zizanol 1656 C15H24O 220 821 Oxidocadalene 1644 C15H18O 214 822 Eremoligenol 1614 C15H26O 222 823 Isohumbertiol D (Isomer 2) 1519 C15H24O 220 824 Isohumbertiol D (Isomer 1) 1490 C15H24O 220 825 Brachylaenalone B 1824 C15H20O2 232 826 Khusien-12-al 1580 C15H22O 218 827 Eudesma-4(15),7(11)-dien-8-one 1713 C15H22O 218 828 Elemenone 1589 C15H22O 218 829 b-Cedrene epoxide 1610 C15H24O 220 830 b-Panasinsen-5a-ol 1621 C15H24O 220 831 Eudesm-7(11)-en-4a-ol 1676 C15H26O 222 832 5,8-Cyclocaryophyllan-4-ol 1514 C15H26O 222 833 Khusol 1769 C15H24O 220 834 cis-10-Hydroxycalamenene 1643 C15H22O 218 835 trans-10-Hydroxycalamenene 1635 C15H22O 218 836 Bryopterine A 1735 C16H20O3 260 837 Isoitalicene epoxide 1501 C15H24O 220 838 Italicene epoxide 1535 C15H24O 220 839 a-Agarofuran 1537 C15H24O 220 840 Longipin-3-en-10-ol 1560 C15H24O 220 841 Dihydrosesquicineol 1467 C15H28O 224 842 Dehydrosesquicineol 1466 C15H24O 220 843 Longicamphenilone 1549 C14H22O 206 844 Longicamphenilol 1578 C14H24O 208 845 Isobutyl angelate 1027 C9H16O2 156 846 Isoacorone 1774 C15H24O2 236 847 Dehydrosesquicineyl-12-ol 1707 C15H24O2 236 848 Dihydrobryopterine A 1763 C16H22O3 262 849 (E)-Nuciferal 1705 C15H20O 216 850 (Z)-Nuciferal 1695 C15H20O 216 851 Pinguisanene 1544 C15H20O 216 852 (E)-Methyl 10-hydroxy-3,7,11- 1930 C16H26O3 266 trimethyldodeca-2,6,11-trienoate 853 Dihydroagarofuran 1500 C15H26O 222 854 Isolongifolol 1717 C15H26O 222 855 (Z)-Nerolidol 1522 C15H26O 222 856 (E)-Nerolidol 1553 C15H26O 222 857 a-Cedrene oxide 1571 C15H24O 220 858 Caryolan-1-ol 1567 C15H26O 222 859 Thujopsan-2a-ol 1584 C15H26O 222 860 Curcerenone 1588 C15H18O2 230 861 a-Guaiol 1593 C15H26O 222 862 Viridiflorol 1592 C15H26O 222 863 Epicurcerenone 1593 C15H18O2 230 864 Carotol 1594 C15H26O 222 865 Cedrol 1603 C15H26O 222 866 12-epi-Cedrol 1620 C15H26O 222 867 1-epi-Cubenol 1623 C15H26O 222 868 ar-Turmerone 1643 C15H20O 216 869 3(15)-Cedren-4-ol 1647 C15H24O 220 870 a-Turmerone 1649 C15H22O 218 871 Patchouli alcohol 1661 C15H26O 222 872 (Z)-a-Santalol 1669 C14H22O 206 873 a-Bisabolol 1673 C15H26O 222 874 Acorenone B 1679 C15H24O 220 875 Germacrone 1684 C15H22O 218 876 Curcuphenol 1693 C15H22O 218 877 2-Butylfuran 869 C8H12O 124 878 Pinguisone 1705 C15H20O2 232 879 (Z)-b-Santalol 1702 C15H24O 220 880 Xanthorhizol 1732 C15H22O 218 881 cis-2-Hydroxycalamenene 1762 C15H22O 218 882 Furanogermenone 1770 C15H20O2 232 883 Alantolactone 1873 C15H20O2 232 884 Dihydroisoalantolactone 1875 C15H22O2 234 885 Frullanolide 1900 C15H20O2 232 886 Isoalantolactone 1912 C15H20O2 232 887 ent-Diplophyllolide 1937 C15H20O2 232 888 Guaia-6,9-dien-4b-ol 1565 C15H24O 220 889 Guaia-6,10(14)-diene-4b-ol 1610 C15H24O 220 890 Cedrenone 1722 C15H22O 218 891 8bH-Cedran-9-one 1608 C15H24O 220 892 Deodarone 1676 C15H24O2 236 893 Pogostol 1647 C15H26O 222 894 Dihydro-ar-turmerone 1570 C15H22O 218 895 Norpatchoulenol 1551 C14H22O 206 896 Caryophyllan-2,6-a-oxide 1412 C15H26O 222 897 Caryophyllen-2,6-b-oxide 1422 C15H26O 222 898 b-Atlantol (Isomer 1) 1436 C15H24O 220 899 b-Atlantol (Isomer 2) 1443 C15H24O 220 900 1,11-Oxidocalamenene 1474 C15H20O 216 901 Furopelargone A 1517 C15H22O2 234 902 Isohumbertiol B 1522 C15H24O 220 903 Silphiperfolene-5-ol 1549 C15H24O 220 904 b-Funebrene epoxide 1591 C15H24O 220 905 b-Himachalene epoxide 1594 C15H24O 220 906 Copaborneol 1595 C15H26O 222 907 10-epi-Italicen-4-one 1615 C15H22O 218 908 ar-Bisabolol 1619 C15H22O 218 909 allo-Aromadendrene epoxide 1623 C15H24O 220 910 Amorph-4-en-10a-ol 1634 C15H26O 222 911 alio-Himachalol 1648 C15H26O 222 912 Farnesal (Isomer 1) 1655 C15H24O 220 913 b-Sesquiphellandrone 1677 C15H22O 218 914 Aromadendran-14-ol 1679 C15H26O 222 915 Farnesal (Isomer 2) 1683 C15H24O 220 916 Farnesal (Isomer 3) 1707 C15H24O 220 917 Longifolol 1707 C15H26O 222 918 Sesquichamaenol 1744 C15H22O2 234 919 (E,E)-Methyl farnesoate 1765 C16H26O2 250 920 trans-2-Hydroxycalamenene 1753 C15H22O 218 921 a-Santalol acetate 1756 C17H26O2 262 922 8-Acetoxyelemol 1759 C17H26O2 262 923 Nootkatone 1782 C15H22O 218 924 Striatol 1550 C15H26O 222 925 Eremophila-1(10),11-dien-9b-ol 1552 C15H24O 220 926 Longipinanol 1559 C15H26O 222 927 Brachyl oxide 1599 C15H24O 220 928 Humulene epoxide 2 1602 C15H24O 220 929 Copaen-15-ol 1661 C15H24O 220 930 Isonaviculol 1743 C15H26O 222 931 Cyperenal 1741 C15H22O 218 932 g-Curcumen-15-al 1744 C15H22O 218 933 Brachylaenalone A 1802 C15H20O2 232 934 Muurola-4,10(14)-dien-8a-ol 1594 C15H24O 220 935 Cadina-1(10),4-dien-8a-ol 1637 C15H24O 220 936 Hexyl acetate 1006 C8H16O2 144 937 Muurola-4,10(14)-dien-8b-ol 1675 C15H24O 220 938 (Z)-Nuciferol 1695 C15H22O 218 939 (Z)-g-Curcumen-12-ol 1701 C15H24O 220 940 (E)-Nuciferol 1715 C15H22O 218 941 (Z)-g-Curcumyl acetate 1767 C17H26O2 262 942 (Z)-Nuciferyl acetate 1793 C17H24O2 260 943 (Z)-Nuciferyl isobutyrate 1916 C19H28O2 288 944 (Z)-g-Curcumenyl isobutyrate 1920 C19H30O2 290 945 (Z)-Nuciferyl 2-methylbutyrate 2003 C20H30O2 302 946 (Z)-g-Curcumyl 2-methylbutyrate 2011 C20H32O2 304 947 Drim-8-en-7-one 1778 C15H24O 220 948 1-Oxo-a-longipinene 1639 C15H22O 218 949 g-Bicyclohomofarnesal 1784 C16H26O 234 950 Geosmin 1392 C12H22O 182 951 Muurol-4-en-6a-ol 1609 C15H26O 222 952 Veticadine oxide 1482 C15H24O 220 953 Cubenol 1630 C15H26O 222 954 4-epi-Cubebol 1490 C15H26O 222 955 Muurol-4-en-3,8-dione 1753 C15H22O2 234 956 3-Acetoxyamorpha-4,7(11)-dien-8- 1950 C17H24O3 276 one 957 (E)-4,8-Dimethylnona-1,3,7-triene 1103 C11H18 150 958 Geijerene 1139 C12H18 162 959 Albene 1154 C12H18 162 960 Trinoranastreptene 1197 C12H16 160 961 1,4a-Dimethyl-1,2,3,4,4a,5,6,7- 1233 C12H20 164 octahydro-naphthalene 962 Pregeijerene 1288 C12H18 162 963 (Z)-2,6,10-Trimethylundeca-2,6- 1305 C14H26 194 diene 964 Isocyclobazzanene 1319 C15H24 204 965 8,9-Didehydrocycloisolongifolene 1320 C15H22 202 966 (E)-2,6,10-Trimethylundeca-2,6- 1321 C14H26 194 diene 967 Cyprotene 1322 C14H24 192 968 Presilphiperfol-1-ene 1325 C15H24 204 969 7aH-Silphiperfol-5-ene 1329 C15H24 204 970 Brasila-5,10-diene 1335 C15H24 204 971 Bicycloax-4(15)-ene 1336 C15H24 204 972 Bicycloelemene 1338 C15H24 204 973 d-Elemene 1340 C15H24 204 974 3,10-Dihydro-1,4-dimethylazulene 1342 C12H14 158 975 Presilphiperfol-7-ene 1342 C15H24 204 976 Pentalenene 1343 C15H24 204 977 African-5-ene 1350 C15H24 204 978 African-2(6)-ene 1350 C15H24 204 979 Maali-1,3-diene 1347 C15H22 202 980 Silphin-1-ene 1350 C15H24 204 981 7bH-Silphiperfol-5-ene 1352 C15H24 204 982 a-Cubebene 1355 C15H24 204 983 Tamariscene 1355 C15H24 204 984 Africa-1,5-diene 1355 C15H22 202 985 African-1-ene 1356 C15H24 204 986 Bicycloax-3-ene 1357 C15H24 204 987 Silphiperfola-5,7(14)-diene 1360 C15H22 202 988 a-Longipinene 1360 C15H24 204 989 Clovene 1365 C15H24 204 990 Cyperadiene 1365 C15H22 202 991 Cyclomyltaylane 1366 C15H24 204 992 1-epi-a-Pinguisene 1367 C15H24 204 993 Brasila-5(10),6-diene 1370 C15H24 204 994 Anastreptene 1373 C15H22 202 995 Capnell-9(12)-ene 1372 C15H24 204 996 a-Ylangene 1376 C15H24 204 997 Isopatchoula-3,5-diene 1377 C15H22 202 998 Cyclosativene 1378 C15H24 204 999 Hirsutene 1378 C15H24 204 1000 a-Copaene 1379 C15H24 204 1001 a-Bourbonene 1378 C15H24 204 1002 Daucene 1380 C15H24 204 1003 Silphiperfol-6-ene 1378 C15H24 204 1004 Bourbon-7-ene 1381 C15H24 204 1005 a-Elemene 1381 C15H24 204 1006 Isodauca-4,7(14)-diene 1381 C15H24 204 1007 Isoledene 1382 C15H24 204 1008 Protoillud-6-ene 1382 C15H24 204 1009 Longicyclene 1382 C15H24 204 1010 Modhephene 1383 C15H24 204 1011 Pacifigorgia-1(9),10-diene 1384 C15H24 204 1012 3-epi-African-5-ene 1384 C15H24 204 1013 10-epi-Italicene 1384 C15H24 204 1014 Asterisca-3(15),6-diene 1385 C15H24 204 1015 a-Funebrene 1385 C15H24 204 1016 b-Panasinsene 1385 C15H24 204 1017 Bicycloopposit-4-ene 1386 C15H24 204 1018 b-Bourbonene 1386 C15H24 204 1019 Isodauca-4,6-diene 1385 C15H24 204 1020 African-2-ene 1387 C15H24 204 1021 7-epi-Sesquithujene 1387 C15H24 204 1022 b-Patchoulene 1388 C15H24 204 1023 a-Duprezianene 1388 C15H24 204 1024 b-Elemene 1389 C15H24 204 1025 a-Isocomene 1389 C15H24 204 1026 1,5-di-epi-a-Bourbonene 1389 C15H24 204 1027 b-Cubebene 1390 C15H24 204 1028 1,5-di-epi-b-Bourbonene 1390 C15H24 204 1029 African-3-ene 1391 C15H24 204 1030 Bicyclo-4(15)-oppositene 1391 C15H24 204 1031 Isolongifolene 1393 C15H24 204 1032 Isodauca-6,9-diene 1393 C15H24 204 1033 Sativene 1394 C15H24 204 1034 Pacifigorgia-1,10-diene 1400 C15H24 204 1035 Petasitene 1398 C15H24 204 1036 Sesquithujene 1399 C15H24 204 1037 African-3(15)-ene 1400 C15H24 204 1038 Cyperene 1402 C15H24 204 1039 b-Longipinene 1403 C15H24 204 1040 7-epi-a-Cedrene 1404 C15H24 204 1041 Helifolene 1406 C15H24 204 1042 7-epi-Helifolene 1406 C15H24 204 1043 Italicene 1408 C15H24 204 1044 Isocaryophyllene 1409 C15H24 204 1045 b-Isocomene 1411 C15H24 204 1046 Longifolene 1411 C15H24 204 1047 Ylanga-2,4(15)-diene 1411 C15H22 202 1048 cis-a-Bergamotene 1411 C15H24 204 1049 allo-Isolongifolene 1412 C15H24 204 1050 Cycloseychellene 1413 C15H24 204 1051 a-Gurjunene 1413 C15H24 204 1052 a-Barbatene 1414 C15H24 204 1053 b-Funebrene 1418 C15H24 204 1054 b-Maaliene 1414 C15H24 204 1055 Pacifigorgia-1(6),10-diene 1414 C15H24 204 1056 Cascarilladiene 1416 C15H24 204 1057 Isosativene 1416 C15H24 204 1058 Tritomarene 1416 C15H24 204 1059 a-Microbiotene 1414 C15H24 204 1060 Aristolene 1423 C15H24 204 1061 a-Cedrene 1418 C15H24 204 1062 Pacifigorgia-2,10-diene 1422 C15H24 204 1063 b-Ylangene 1420 C15H24 204 1064 (Z)-b-Farnesene 1420 C15H24 204 1065 Acora-3,5-diene 1421 C15H24 204 1066 (E)-b-Caryophyllene 1421 C15H24 204 1067 a-Santalene 1422 C15H24 204 1068 Spirovetiva-1(10),6-diene 1422 C15H24 204 1069 b-Duprezianene 1423 C15H24 204 1070 Opposita-4(15),7-diene 1423 C15H24 204 1071 b-Cedrene 1424 C15H24 204 1072 Opposita-4(15),11-diene 1424 C15H24 204 1073 Selina-3,6-diene 1424 C15H24 204 1074 Bourbon-11-ene 1424 C15H24 204 1075 Dauca-3,8-diene 1428 C15H24 204 1076 Elema-1,3,7(11),8-tetraene 1428 C15H22 202 1077 g-Elemene 1429 C15H24 204 1078 Isobarbatene 1428 C15H24 204 1079 g-Maaliene 1428 C15H24 204 1080 Aristola-1(10),8-diene 1429 C15H22 202 1081 Chenopodene 1430 C15H24 204 1082 b-Copaene 1430 C15H24 204 1083 Thujopsene 1434 C15H24 204 1084 Selina-4(15),5-diene 1433 C15H24 204 1085 Pacifigorgia-2(10),11-diene 1435 C15H24 204 1086 trans-a-Bergamotene 1434 C15H24 204 1087 a-Pinguisene 1436 C15H24 204 1088 b-Sesquifenchene 1437 C15H24 204 1089 Sesquisabinene A 1435 C15H24 204 1090 Calarene 1437 C15H24 204 1091 Cubeb-11-ene 1445 C15H24 204 1092 b-Gorgonene 1440 C15H24 204 1093 a-Maalinene 1440 C15H24 204 1094 Cyclofarnesa-5(14),8,10-triene 1441 C15H24 204 1095 a-Guaiene 1440 C15H24 204 1096 Acora-3,9-diene 1442 C15H24 204 1097 Aromadendrene 1443 C15H24 204 1098 Brasila-1(6),5(10)-diene 1442 C15H24 204 1099 Isobazzanene 1442 C15H24 204 1100 Guaia-6,9-diene 1443 C15H24 204 1101 Nardosina-7,9,11-triene 1444 C15H22 202 1102 4aH,10aH-Guaia-1(5),6-diene 1445 C15H24 204 1103 Isogermacrene D 1445 C15H24 204 1104 Selina-5,11-diene 1444 C15H24 204 1105 Eremophila-1(10),6-diene 1445 C15H24 204 1106 b-Barbatene 1445 C15H24 204 1107 Cadina-4,11-diene 1458 C15H24 204 1108 Erythrodiene 1446 C15H24 204 1109 epi-b-Santalene 1446 C15H24 204 1110 Sesquisabinene B 1446 C15H24 204 1111 Seychellene 1447 C15H24 204 1112 Cadina-3,5-diene 1448 C15H24 204 1113 (E)-b-Farnesene 1446 C15H24 204 1114 4bH,10aH-Guaia-1(5),6-diene 1448 C15H24 204 1115 Selina-4(15),6-diene 1450 C15H24 204 1116 a-Himachalene 1450 C15H24 204 1117 Prezizaene 1452 C15H24 204 1118 Bourbon-7(11)-ene 1454 C15H24 204 1119 a-Humulene 1455 C15H24 204 1120 e-Muurolene 1455 C15H24 204 1121 a-Panasinsene 1455 C15H24 204 1122 Zizaene 1456 C15H24 204 1123 a-Neoclovene 1456 C15H24 204 1124 Valerena-4,7(11)-diene 1456 C15H24 204 1125 Acora-3,10(14)-diene 1457 C15H24 204 1126 Selina-4(15),7-diene 1457 C15H24 204 1127 b-Spathulene 1457 C15H22 202 1128 Muurola-4,11-diene 1458 C15H24 204 1129 Selina-2,4-diene 1462 C15H24 204 1130 (Z,Z)-a-Farnesene 1460 C15H24 204 1131 b-Santalene 1460 C15H24 204 1132 7bH,10bH-Cadina-1(6),4-diene 1460 C15H24 204 1133 Rotundene 1461 C15H24 204 1134 Selina-3,7-diene 1460 C15H24 204 1135 Striatene 1458 C15H24 204 1136 allo-Aromadendrene 1462 C15H24 204 1137 Aromadendr-9-ene 1463 C15H24 204 1138 a-Patchoulene 1467 C15H24 204 1139 a-Acoradiene 1464 C15H24 204 1140 Carota-5,8-diene 1465 C15H24 204 1141 b-Acoradiene 1465 C15H24 204 1142 4,5-di-epi-Aristolochene 1470 C15H24 204 1143 Selina-4,7-diene 1469 C15H24 204 1144 2-epi-(E)-b-Caryophyllene 1467 C15H24 204 1145 g-Muurolene 1474 C15H24 204 1146 Amorpha-4,11-diene 1472 C15H24 204 1147 7aH,10bH-Cadina-1(6),4-diene 1472 C15H24 204 1148 ar-Curcumene 1473 C15H22 202 1149 Eudesma-1,4(15),11-triene 1472 C15H22 202 1150 Eudesma-2,4,11-triene 1471 C15H22 202 1151 g-Gurjunene 1472 C15H24 204 1152 Ishwarane 1468 C15H24 204 1153 Valenca-2,9,11-trIene 1473 C15H22 202 1154 b-Chamigrene 1474 C15H24 204 1155 (3E,6Z)-a-Farnesene 1475 C15H24 204 1156 Selina-4,11-diene 1475 C15H24 204 1157 b-Microbiotene 1473 C15H24 204 1158 a-Amorphene 1477 C15H24 204 1159 g-Curcumene 1475 C15H24 204 1160 Herbertene 1476 C15H22 202 1161 Zierene 1476 C15H22 202 1162 a-Neocallitropsene 1475 C15H24 204 1163 Amorpha-4,7(11)-diene 1476 C15H24 204 1164 5-epi-Aristolochene 1477 C15H24 204 1165 Isobicyclogermacrene 1477 C15H24 204 1166 b-Neoclovene 1475 C15H24 204 1167 trans-b-Bergamotene 1480 C15H24 204 1168 g-Himachalene 1479 C15H24 204 1169 Laurene 1483 C15H20 200 1170 Germacrene D 1479 C15H24 204 1171 (3Z,6E)-a-Farnesene 1480 C15H24 204 1172 a-Vetispirene 1481 C15H22 202 1173 e-Cadinene 1483 C15H24 204 1174 g-Humulene 1483 C15H24 204 1175 Isolepidozene 1483 C15H24 204 1176 cis-Eudesma-6,11-diene 1484 C15H24 204 1177 Nardosina-9,11-diene 1484 C15H24 204 1178 Nardosina-1(10),11-diene 1484 C15H24 204 1179 Eudesma-3,5,11-triene 1485 C15H22 202 1180 Aristolochene 1486 C15H24 204 1181 Eremophilene 1486 C15H24 204 1182 d-Selinene 1490 C15H24 204 1183 b-Vetispirene 1486 C15H22 202 1184 Bicyclosesquiphellandrene 1487 C15H24 204 1185 b-Selinene 1486 C15H24 204 1186 g-Amorphene 1492 C15H24 204 1187 allo-Aromadendr-9-ene 1489 C15H24 204 1188 Eremophila-1(10),7-diene 1488 C15H24 204 1189 Selina-3,5-diene 1486 C15H24 204 1190 Zingiberene 1489 C15H24 204 1191 b-Alaskene 1495 C15H24 204 1192 Ledene 1491 C15H24 204 1193 Drim-8(12)-ene 1497 C15H26 206 1194 Valencene 1494 C15H24 204 1195 epi-Zonarene 1494 C15H24 204 1196 (Z)-a-Bisabolene 1494 C15H24 204 1197 a-Selinene 1494 C15H24 204 1198 Bicyclogermacrene 1494 C15H24 204 1199 Caparratriene 1493 C15H26 206 1200 Eudesma-2,4(15),11-triene 1495 C15H22 202 1201 Hinesene 1495 C15H24 204 1202 a-Muurolene 1496 C15H24 204 1203 Aciphyllene 1495 C15H24 204 1204 a-Cuprenene 1497 C15H24 204 1205 Cuparene 1498 C15H22 202 1206 g-Patchoulene 1497 C15H24 204 1207 e-Amorphene 1498 C15H24 204 1208 g-Guaiene 1499 C15H24 204 1209 b-Pinguisene 1500 C15H24 204 1210 d-Amorphene 1499 C15H24 204 1211 (E,E)-a-Farnesene 1498 C15H24 204 1212 1aH,10aH-Guaia-4,6-diene 1500 C15H24 204 1213 b-Himachalene 1500 C15H24 204 1214 D7(14)-ar-Himachalene 1501 C15H20 200 1215 b-Bisabolene 1503 C15H24 204 1216 a-Chamigrene 1503 C15H24 204 1217 Eremophila-1(10),8,11-triene 1504 C15H22 202 1218 Germacrene A 1503 C15H24 204 1219 Isorotundene 1503 C15H24 204 1220 a-Bulnesene 1503 C15H24 204 1221 b-Curcumene 1503 C15H24 204 1222 Drimenene 1503 C15H24 204 1223 Pseudowiddrene 1503 C15H24 204 1224 a-Alaskene 1512 C15H24 204 1225 (Z)-g-Bisabolene 1505 C15H24 204 1226 g-Cadinene 1507 C15H24 204 1227 Nootkatene 1512 C15H22 202 1228 Cyclobazzanene 1514 C15H24 204 1229 cis-Calamenene 1517 C15H22 202 1230 b-Sesquiphellandrene 1516 C15H24 204 1231 D7,8-ar-Himachalene 1518 C15H20 200 1232 7-epi-a-Selinene 1519 C15H24 204 1233 b-Bazzanene 1519 C15H24 204 1234 d-Cadinene 1520 C15H24 204 1235 (E)-g-Bisabolene 1521 C15H24 204 1236 trans-Calamenene 1517 C15H22 202 1237 Zonarene 1521 C15H24 204 1238 b-Cadinene 1526 C15H24 204 1239 g-Cuprenene 1523 C15H24 204 1240 Spirovetiva-1(10),7(11)-diene 1523 C15H24 204 1241 g-Vetivenene 1525 C15H22 202 1242 Cadina-1,4-diene 1523 C15H24 204 1243 w-Cadinene 1526 C15H24 204 1244 a-Calacorene 1527 C15H20 200 1245 Eremophila-1(10),7(11)-diene 1527 C15H24 204 1246 ar-Himachalene 1528 C15H22 202 1247 (E)-a-Bisabolene 1530 C15H24 204 1248 5-epi-Laurene 1531 C15H20 200 1249 1,4-Dimethylazulene 1532 C12H12 156 1250 Selina-4(15),7(11)-diene 1534 C15H24 204 1251 a-Cadinene 1534 C15H24 204 1252 w-Amorphene 1540 C15H24 204 1253 d-Cuprenene 1546 C15H24 204 1254 (1(10)E,4Z)-Germacrene B 1543 C15H24 204 1255 Selina-3,7(11)-diene 1542 C15H24 204 1256 Germacrene B 1552 C15H24 204 1257 b-Vetivenene 1552 C15H22 202 1258 g-Calacorene 1554 C15H20 200 1259 (3E,7E)-4,8,12-Trimethyltrideca- 1565 C16H26 218 1,3,7,11-tetraene 1260 Cadalene 1659 C15H18 198 1261 Daucalene 1671 C15H18 198 1262 Chamazulene 1719 C14H16 184 1263 Guaiazulene 1761 C15H18 198 1264 6-epi-b-Cubebene 1449 C15H24 204 1265 e-Cuprenene 1524 C15H24 204 1266 Gymnomitra-3(15),4-diene 1413 C15H22 202 1267 Tenuifolene 1570 C15H22 202 1268 ar-Tenuifolene 1528 C15H20 200 1269 trans-Eudesma-3,5-diene 1490 C15H24 204 1270 Pethybrene 1440 C15H24 204 1271 Premnaspirodiene 1516 C15H24 204 1272 Spirolepechinene 1450 C15H24 204 1273 trans-Dauca-4(11),7-diene 1554 C15H24 204 1274 trans-Dauca-4(11),8-diene 1529 C15H24 204 1275 Cadina-1(10),3,7(11)-triene 1575 C15H22 202 1276 7,8-Dehydro-a-acoradiene 1450 C15H22 202 1277 cis-Muurola-4(15),5-diene 1462 C15H24 204 1278 Patchoula-2,4(15)-diene 1434 C15H22 202 1279 Norrotundene 1421 C14H22 190 1280 cis-b-Guaiene 1488 C15H24 204 1281 Bisaboia-1,3,5,11-tetraene 1461 C15H24 204 1282 4-epi-b-Patchoulene 1376 C15H24 204 1283 d-Patchoulene 1466 C15H24 204 1284 e-Patchoulene 1473 C15H24 204 1285 10-epi-Muurola-4,11-diene 1458 C15H24 204 1286 Dauca-8,11-diene 1431 C15H24 204 1287 Neotrifaradiene 1365 C15H24 204 1288 Sandvicene 1399 C15H24 204 1289 Trifara-9,14-diene 1403 C15H24 204 1290 cis-Muurola-3,5-diene 1447 C15H24 204 1291 Pacifigorgia-6,10-diene 1429 C15H24 204 1292 b-Bulnesene 1558 C15H24 204 1293 Isocalamenene 1527 C15H22 202 1294 Myltayl-4(12)-ene 1452 C15H24 204 1295 3,7-di-epi-Trifara-9,14-diene 1399 C15H24 204 1296 6-epi-a-Cubebene 1418 C15H24 204 1297 2-Sterpurene 1351 C15H24 204 1298 a-Corocalen 1602 C15H20 200 1299 Lactarazulene 1796 C15H16 196 1300 Prenyllimonene (Isomer 1) 1436 C15H24 204 1301 Prenyllimonene (Isomer 2) 1450 C15H24 204 1302 Cadina-1(10),7(11)-diene 1538 C15H24 204 1303 Elema-1,3,7-triene 1346 C15H24 204 1304 7-epi-Cadina-1(10),11-diene 1525 C15H24 204 1305 Cadina-1(10),11-diene 1480 C15H24 204 1306 Vetivazulene 1790 C15H18 198 1307 Mintsulphide 1734 C15H24S 236 1308 Brasila-1,10-diene 1307 C15H24 204 1309 Drim-8-ene 1442 C15H26 206 1310 Selina-4(15),7,11-triene 1469 C15H22 202 1311 5,6-Dehydroalaskene 1371 C15H22 202 1312 (all-Z)-6,9,12,15-Heneicosatetraene 2048 C21H36 288 1313 Isoperillene 1073 C10H14O 150 1314 (E)-Cinnamyl isovalerate 1641 C14H18O2 218 1315 (E)-Cinnamyl isobutyrate 1543 C13H16O2 204 1316 (E)-Cinnamyl propionate 1500 C12H14O2 190 1317 (Z)-Isobutyl cinnamate 1593 C13H16O2 204 1318 Phenylethyl tiglate 1547 C13H16O2 204 1319 7-epi-Eremophila-1(10),8,11-triene 1508 C15H22 202 1320 5-Hydroxymarsupellyl acetate 1814 C17H26O3 278 1321 Marsupellyl acetate 1681 C17H26O2 262 1322 4-epi-Marsupellyl acetate 1733 C17H26O2 262 1323 (E)-Methyl p-methoxycinnamate 1625 C11H12O3 192 1324 (Z)-Methyl p-methoxycinnamate 1543 C11H12O3 192 1325 4-epi-Marsupellol 1614 C15H24O 220 1326 (Z)-Cinnamyl propionate 1552 C12H14O2 190 1327 (E)-Isobutyl cinnamate 1633 C13H16O2 204 1328 Methyl 4-methoxymandelate 1511 C10H12O4 196 1329 (E)-Isoamyl cinnamate 1697 C14H18O2 218 1330 Pentadecanoic acid 1823 C15H30O2 242 1331 Methyl o-methoxybenzoate 1300 C9H10O3 166 1332 Patchenol 1305 C11H18O 166 1333 Syringa aldehyde 1599 C9H10O4 182 1334 Methyl 3-methylorsellinate 1674 C10H12O4 196 1335 Dihydroactinidiolide 1487 C11H16O2 180 1336 b-Ionone epoxide 1460 C13H20O2 208 1337 Oxoisophorone 1111 C9H12O2 152 1338 Sabina ketone 1132 C9H14O 138 1339 2,6-Di-tert-butyl-4-methylphenol 1492 C15H24O 220 1340 Cadin-1(10)-ene 5,11-oxide 1574 C15H24O 220 1341 6,11-Epoxyisodaucane 1463 C15H26O 222 1342 3-Acetoxy-b-ionone 1752 C15H22O3 250 1343 Nardosina-7,9-dien-11-ol 1596 C15H24O 220 1344 Porosadienol 1627 C15H24O 220 1345 a-Ionone epoxide (Isomer 2) 1512 C13H20O2 208 1346 Cabreuva oxide A 1437 C15H24O 220 1347 Cabreuva oxide B 1452 C15H24O 220 1348 Cabreuva oxide C 1456 C15H24O 220 1349 (E)-o-Methoxycinnamaldehyde 1477 C10H10O2 162 1350 (Z)-o-Methoxycinnamaldehyde 1408 C10H10O2 162 1351 Hydrocinnamyl acetate 1336 C11H14O2 178 1352 N-Methyl methyl anthranilate 1372 C9H11O2N 165 1353 Abietal 2261 C20H30O 286 1354 trans-Totarol 2241 C20H30O 286 1355 Dehydrogeosmin 1362 C12H20O 180 1356 1bH,5aH,7bH-Guaia-3,10(14)-dien- 1646 C15H24O 220 11-ol 1357 9a,11-Epoxy-1bH,5aH,7bH,9bH- 1587 C15H22O 218 guaia-3,10(14)-diene 1358 4-(4-Hydroxyphenyl)-2-butanone 1508 C10H12O2 164 1359 15-Norlabdan-8-ol 1943 C19H36O 280 1360 Oxoisoambrox 1819 C16H26O2 250 1361 Sclareolide 2022 C16H24O3 264 1362 1-Decanol 1264 C10H22O 158 1363 Amberone 1810 C17H26O 246 1364 Methyl arachidonate 2217 C21H34O2 318 1365 Cyclomyltaylan-15-ol 1641 C15H24O 220 1366 Tridenson 1633 C15H26O 222 1367 Tridensenal 1617 C15H26O 222 1368 6b-Acetoxyeudesm-4(15)-en-7b-ol 1898 C18H30O2 278 1369 Tridensenone 1815 C15H20O 216 1370 2,6,6-Trimethylcyclohexanone 1023 C9H16O 140 1371 2,6,6-Trimethylcyclohex-2-enone 1045 C9H14O 138 1372 Acetoxycedren-13-ol 1782 C17H26O2 262 1373 4-Isopropylcyclohexanol (Isomer 1) 1126 C9H18O 142 1374 3-Hydroxy-4-methoxybenzyl 1421 C8H10O3 154 alcohol 1375 a-Ambrinol (Isomer 1) 1382 C13H22O 194 1376 a-Ambrinol (Isomer 2) 1410 C13H22O 194 1377 Thymohydroquinone 1509 C10H14O2 166 1378 Oreodaphnenol 1484 C15H24O 220 1379 Ambrox 1747 C16H28O 236 1380 4-Isopropylphenol 1201 C9H12O 136 1381 Scopoletine 1888 C10H8O4 192 1382 2,5-Dimethoxy-4-isopropyltoluene 1400 C12H18O2 194 1383 Silphiperfol-5-en-3-one 1533 C15H22O 218 1384 Clovenol 1575 C15H24O 220 1385 trans-6-Hydroxyisocalamenene 1782 C15H22O 218 1386 1,4-trans-6-Methoxyisocalamenene 1722 C16H24O 232 1387 Non-1-ene 837 C9H18 126 1388 Mintoxide 1565 C15H24O 220 1389 6-Methylheptan-2,4-dione 975 C8H14O2 142 1390 5-Methylheptan-2,4-dione 966 C8H14O2 142 1391 2,2-Dimethyl-7-isobutyl-2H,5H- 1770 C14H18O3 234 pyrano[4.3-b]pyran-5-one 1392 2,2-Dimethyl-7-secbutyl-2H,5H- 1764 C14H18O3 234 pyrano[4.3-b]pyran-5-one 1393 Cyclo-b-ionone 1329 C13H20O 192 1394 Germacra-4(15),5,10(14)-trien-1a-ol 1680 C15H24O 220 1395 Eudesma-4(15),7-dien-1b-ol 1671 C15H24O 220 1396 Cadina-4,10(14)-dien-1a-ol 1662 C15H24O 220 1397 b-Calacorene 1541 C15H20 200 1398 1a,10a-Epoxyamorph-4-ene 1569 C15H24O 220 1399 Muurola-4,10(14)-dien-1-ol 1626 C15H24O 220 1400 Caryophylla-3(15),7(14)-dien-6-ol 1635 C15H24O 220 1401 4(15)-Dehydroglobulol 1597 C15H24O 220 1402 trans-Bisabola-1(6),10-dien-2,3-diol 1758 C15H26O2 238 1403 6,10-Epoxybisabol-2-en-12-al 1664 C15H24O2 236 1404 6,10-Epoxybisabol-3-en-12-al 1677 C15H24O2 236 1405 11-epi-6,10-Epoxybisabol-3-en-12- 1649 C15H24O2 236 al 1406 Acora-3,5-dien-11-ol 1574 C15H24O 220 1407 Acora-2,4(15)-dien-11-ol 1616 C15H24O 220 1408 7-epi-Bisabol-1-one 1718 C15H24O 220 1409 (E)-trans-a-Bergamota-2,10-dien-12- 1679 C15H22O 218 al 1410 Helifolen-12-al (syn-syn-syn) 1611 C16H24O 232 1411 Italicene ether 1531 C15H24O 220 1412 7-epi-b-Bisabolol 1657 C15H26O 222 1413 Bisabol-1-one 1712 C15H24O 220 1414 Humulene epoxide 1 1593 C14H22O 206 1415 10-epi-Italicene ether 1511 C15H24O 220 1416 3-Hydroxybisabola-1(6),10-dien-2- 1748 C15H24O2 236 one 1417 b-Bisabolol 1659 C15H26O 222 1418 10-epi-Junenol 1581 C15H26O 222 1419 Junenol 1617 C15H26O 222 1420 1,10-di-epi-Cubenol 1615 C15H26O 222 1421 Carquejyl acetate 1284 C12H16O2 192 1422 (E)-Dendrolasin 1566 C15H22O 218 1423 Artemisyl acetate 1164 C12H20O2 196 1424 Artedouglasia oxide C 1507 C15H22O3 250 1425 Artedouglasia oxide A 1517 C15H22O3 250 1426 1-Undecanol 1363 C11H24O 172 1427 Laciniata furanone H 1530 C15H22O3 250 1428 Lanciniata furanone F 1514 C15H22O3 250 1429 Artedouglasia oxide B 1561 C15H22O3 250 1430 Artedouglasia oxide D 1542 C15H22O3 250 1431 Cymen-8-ol 1169 C10H14O 150 1432 2,2,9-Trimethyl-1,6- 1079 C10H14O2 166 dioxaspiro[4.4]nona-3,8-diene 1433 Menthyl formate 1230 C11H20O2 184 1434 Folifolone 1090 C10H14O 150 1435 Santolina alcohol 1029 C10H18O 154 1436 cis-p-Mentha-1(7),8-dien-2-ol 1217 C10H16O 152 1437 trans-p-Mentha-1(7),8-dien-2-ol 1176 C10H16O 152 1438 trans-p-Menth-2-en-1-ol 1116 C10H18O 154 1439 cis-p-Mentha-2,8-dien-1-ol 1125 C10H16O 152 1440 trans-p-Mentha-2,8-dien-1-ol 1113 C10H16O 152 1441 Dehydrosabinaketone 1100 C9H12O 136 1442 4-Hydroxy-4-methylcyclohex-2- 1089 C7H10O2 126 enone 1443 2-(1-Hydroxyethyl)-5-methyl-5- 1054 C9H16O2 156 vinyltetrahydrofuran 1444 trans-Arbusculone 1036 C9H14O2 154 1445 Lavender lactone 1006 C7H10O2 126 1446 Pulegone epoxide 1238 C10H16O2 168 1447 3-Methylcyclohexanone 928 C7H12O 112 1448 trans-Linalool oxide acetate 1274 C12H20O3 212 1449 Fragranyl acetate 1331 C11H18O2 182 1450 6-Methyl-6-(3-methylphenyl)-2- 1609 C15H22O 218 heptanone 1451 3-exo-Acetoxybornyl acetate 1520 C14H22O4 254 1452 3-exo-Acetoxyborneol 1402 C12H20O3 212 1453 3-exo-Hydroxybornyl acetate 1393 C12H20O3 212 1454 Lavandulyl acetate 1275 C12H20O2 196 1455 5-Hydroxymarsupellol 1776 C15H24O2 236 1456 b-Isolongibornene 1440 C15H24 204 1457 Geranyl propionate 1486 C13H22O2 210 1458 (E)-Isosafrol 1356 C10H10O2 162 1459 2,3-Dihydrofarnesol 1674 C15H28O 224 1460 Methyl 4-hydroxymandelate 1572 C9H10O4 182 1461 Methyl 3-(4-methoxyphenyl)- 1494 C11H14O3 194 propionate 1462 Methyl 3,5-dimethoxyphenylacetate 1603 C11H14O4 210 1463 2a-Hydroxyamorpha-4,7(11)-diene 1678 C15H24O 220 1464 l-Hepten-3-one 956 C7H12O 112 1465 Ferulyl angelate 1682 C15H20O3 248 1466 Undecanal 1290 C11H22O 170 1467 n-Hexadecanoic acid 1951 C16H32O2 256 1468 n-Tetradecanoic acid 1748 C14H28O2 228 1469 n-Dodecanoic acid 1554 C12H24O2 200 1470 n-Decanal 1180 C10H20O 156 1471 Axenol (Gleenol) 1574 C15H26O 222 1472 epi-Methyl jasmonate 1637 C13H20O3 224 1473 5-Ethylcyclopent-1-enecarbaldehyde 1010 C8H12O 124 1474 Methyl hexanoate 905 C7H14O2 130 1475 Methyl undecanoate 1400 C12H24O2 200 1476 Methyl dodecanoate 1500 C13H26O2 214 1477 Methyl tridecanoate 1600 C14H28O2 228 1478 Methyl myristoleate 1683 C15H28O2 240 1479 (Z)-Methyl pentadec-10-enoate 1786 C16H30O2 254 1480 Methyl palmitoleate 1877 C17H32O2 268 1481 (Z)-Methyl Heptadec-10-enoate 1978 C18H34O2 282 1482 Methyl heptadecanoate 2001 C17H34O2 270 1483 Methyl oleate 2082 C19H36O2 296 1484 Dihydroedulan 1290 C13H22O 194 1485 2-Methylbenzofuran 1149 C9H8O 132 1486 (all-Z)-Methyl Docosa- 2395 C23H34O2 342 4,7,10,13,16,19-hexaenoate 1487 (Z,Z)-Methyl docosa-13,16-dienoate 2433 C23H42O2 350 1488 Methyl erucate 2440 C23H44O2 352 1489 Methyl behenate 2459 C23H46O2 354 1490 Methyl tricosanoate 2558 C24H48O2 368 1491 Methyl nervonate 2650 C25H48O2 380 1492 (Z)-Methyl eicosa-11-enoate 2248 C21H40O2 324 1493 Methyl lignocerate 2695 C25H50O2 382 1494 Methyl arachidate 2306 C21H42O2 326 1495 Methyl heneicosanoate (C-21) 2412 C22H44O2 340 1496 Methyl stearate 2104 C19H38O2 298 1497 (all-Z)-Methyl eicosa-11,14-dienoate 2243 C22H40O2 336 1498 Methyl elaidate 2084 C19H36O2 296 1499 Methyl linolenate 2036 C19H32O2 292 1500 Methyl linoleate 2046 C19H34O2 294 1501 Methyl palmitate 1901 C17H34O2 270 1502 Methyl pentadecanoate 1796 C16H32O2 256 1503 Methyl myristate 1700 C15H30O2 242 1504 Methyl octanoate 1100 C91H8O2 158 1505 Methyl nonanoate 1208 C10H20O2 172 1506 Methyl decanoate 1300 C11H22O2 186 1507 (3Z,9E)-Isoligustilide 1824 C12H14O2 190 1508 (Z)-3-Butyliden-4,5,6,7- 1697 C12H16O2 192 tetrahydrophthalide 1509 Neophytadiene (Isomer 1) 1807 C20H38 278 1510 Neophytadiene (Isomer 2) 1830 C20H38 278 1511 Neophytadiene (Isomer 3) 1849 C20H38 278 1512 Eudesm-3-ene 6,7-oxide 1787 C15H24O 220 1513 Eudesma-3,7(11)-dien-8-one 1745 C15H22O 218 1514 5-Methylfurfural 941 C6H6O2 110 1515 g-Costol 1732 C15H24O 220 1516 a-Costol 1761 C15H24O 220 1517 b-Costol 1754 C15H24O 220 1518 Dehydrocostunolide 1956 C15H18O2 230 1519 Dihydrodehydrocostus lactone 1903 C15H20O2 232 1520 Eudesma-4(15),11-dien-8-one 1643 C15H22O 218 1521 (E)-15,16-Bisnorlabda-8(17),12- 2051 C18H28O 260 dien-14-al 1522 (E)-15,16-Bisnorlabda-8(17),11- 1958 C18H28O 260 dien-13-one 1523 Albicanol 1736 C16H28O 236 1524 g-Bicyclofarnesal 1656 C15H24O 220 1525 trans-6,6,10-Trimethyl-2-decalone 1505 C13H22O 194 1526 Coronarin E 2095 C20H28O 284 1527 10-Hydroxy-4-oplopanone 1708 C15H26O2 238 1528 Valerenic acid 1843 C15H22O2 234 1529 Vulgarone A 1580 C15H22O 218 1530 Artemisiatriene 923 C10H16 136 1531 2-Methylbutyl octanoate 1427 C13H26O2 214 1532 Hexyl hexanoate 1363 C12H24O2 200 1533 (E)-2-Decenal 1240 C10H18O 154 1534 2-methylbutyl hexanoate 1235 C11H22O2 186 1535 n-Hexyl 2-methylbutanoate 1220 C11H22O2 186 1536 n-Hexyl butanoate 1176 C10H20O2 172 1537 (E)-2-Heptenal 942 C7H12O 112 1538 Fenchyl acetate (Isomer) 1224 C12H20O2 196 1539 11-Nordrim-8-en-12-al 1609 C14H22O 206 1540 Undecanoic acid 1452 C11H22O2 186 1541 Allyl-2,4-di-acetoxybenzene 1592 C13H14O4 234 1542 n-Decane 993 C10H22 142 1543 n-Dodecane 1200 C12H26 170 1544 n-Tridecane 1300 C13H28 184 1545 n-Tetradecane 1392 C14H30 198 1546 n-Pentadecane 1500 C15H32 212 1547 n-Hexadecane 1600 C16H34 226 1548 n-Heptadecane 1700 C17H36 240 1549 n-Octadecane 1792 C18H38 254 1550 n-Eicosane (C-20) 2000 C20H42 282 1551 n-Heneicosane (C-21) 2100 C21H44 296 1552 n-Docosane (C-22) 2200 C22H46 310 1553 n-Tricosane (C-23) 2301 C23H48 324 1554 n-Tetracosane (C-24) 2400 C24H50 338 1555 n-Pentacosane (C-25) 2498 C25H52 352 1556 n-Hexacosane (C-26) 2598 C26H54 366 1557 Verbenene 982 C10H14 134 1558 trans-Chrysanthenyl acetate 1214 C12H18O2 194 1559 trans-Chrysanthenol 1096 C10H16O 152 1560 (Z)-2,6-Dimethylocta-1,5,7-trien-3- 1048 C10H16O 152 ol 1561 (E)-2,6-Dimethylocta-1,5,7-trien-3- 1058 C10H16O 152 ol 1562 Dihydrodiplophylline 1896 C15H22O2 234 1563 Diplophylline 1965 C15H20O2 232 1564 Ginsensene 1353 C15H24 204 1565 2-Methyl-2,5-divinyltetrahydrofuran 900 C9H14O 138 1566 5-Ethyl-2-methyl-2- 893 C9H16O 140 vinyltetrahydrofuran 1567 (all-E)-1,7-Dimethylcyclodeca- 1274 C12H18 162 1,4,7-triene 1568 Salviadienol 1545 C15H24O 220 1569 Torilenol 1599 C13H20O 192 1570 Betaer-13-ene 2040 C20H32 272 1571 Ethylbenzene 843 C8H10 106 1572 4-epi-11-Noraristola-9,11-diene 1399 C14H20 188 1573 4-epi-11-Noraristola-1,9,11-triene 1419 C14H18 186 1574 4-epi-11-Noraristola-1(10),11-diene 1409 C14H20 188 1575 4-Ethylguiacol 1257 C9H12O2 152 1576 2-Hydroxy-4-methoxyacetophenone 1294 C9H10O3 166 1577 4-Vinylanisol 1134 C9H10O 134 1578 p-Ethylanisol 1099 C9H12O 136 1579 1-Acetoxy-4-ethylbenzene 1238 C10H12O2 164 1580 Tetradecanal 1596 C14H28O 212 1581 4-Ethylphenol 1139 C8H10O 122 1582 Dehydropinguisenol 1800 C15H20O2 232 1583 Fusicocca-2,5-diene 2020 C20H32 272 1584 Crispatanolide 1760 C15H22O2 234 1585 (+)-Himachala-2,4-diene 1433 C15H24 204 1586 Polygodial 1839 C15H22O2 234 1587 9-epi-Polygodial 1960 C15H22O2 234 1588 Dihydrofrullanolide 1874 C15H22O2 234 1589 Eudesma-3,11-dien-8-one 1666 C15H22O 218 1590 5,8a-Dimethyl-3,4,4a,7,8,8a- 1464 C12H18O 178 hexahydro-1H-naphthalen-2-one 1591 8a-Hydroxyeudesma-3,11-diene 1668 C15H24O 220 1592 6,11-Epoxyeudesmane 1521 C15H26O 222 1593 Eudesma-5,7(11)-diene 1543 C15H24 204 1594 6b-Hydroxyeudesm-11-ene 1643 C15H26O 222 1595 6a-Hydroxyeudesm-11-ene 1598 C15H26O 222 1596 6,7-seco-Eudesm-7(11)-en-6-al 1615 C15H26O 222 1597 Ipsenol 1083 C10H18O 154 1598 Phytane 1808 C20H42 282 1599 Farnesane 1375 C15H32 212 1600 b-n-Octyl-g-butanolide 1655 C12H22O2 198 1601 Crocetane 1810 C20H42 282 1602 Pristane 1706 C19H40 268 1603 cis-Eudesma-4,11-dien-8-ol 1648 C15H24O 220 1604 Bisabola-1(6),2,10Z-trien-12-al 1733 C15H22O 218 1605 8,9-Epoxyselina-4,11-diene 1597 C15H22O 218 1606 Eudesma-4(15),11-dien-5-ol 1629 C15H24O 220 1607 cis-Eudesma-4(15),11-dien-5-ol 1623 C15H24O 220 1608 Pentadecanal 1702 C15H30O 226 1609 3-Methylbutanolide 909 C5H8O2 100 1610 2-n-Propyl-g-butanolide 1100 C7H12O2 128 1611 2-n-Pentyl-g-butanolide 1311 C9H16O2 156 1612 2-Ethylbutanolide 1000 C6H10O2 114 1613 2-Methylbutanolide 902 C5H8O2 100 1614 4-Allyl-g-butanolide 1090 C7H10O2 126 1615 d-Tetradecalactone 1893 C14H26O2 226 1616 d-Tridecanolide 1786 C13H24O2 212 1617 d-Dodecanolide 1675 C12H22O2 198 1618 g-n-Tetradecyl-g-butanolide 2720 C18H34O2 282 1619 d-Hexaolide 1044 C6H10O2 114 1620 N-2-[(4-Hydroxyphenyl)-ethyl]- 2325 C13H17O2N 219 tiglamide 1621 4-Hydroxy-b-ionone 1628 C13H20O2 208 1622 (E)-Megastigm-7-en-3,9-dione (t) 1572 C13H20O2 208 1623 a-Helmiscapene 1447 C15H24 204 1624 Methyl 2-(2-methylbutyroxy)-3- 1339 C12H22O4 230 methylpentanoate 1625 7,8-Dihydro-b-ionol 1431 C13H24O 196 1626 Dodecyl acetate 1585 C14H28O2 228 1627 (Z)-Heptadec-8-ene 1666 C17H34 238 1628 cis-Dracunculifolione 1500 C15H24O 220 1629 Italicen-13-ol 1670 C15H24O 220 1630 10-epi-cis-Dracunculifoliol 1533 C15H26O 222 1631 cis-Dracunculifoliol 1534 C15H26O 222 1632 trans-Dracunculifoliol 1581 C15H26O 222 1633 3-Hydroxy-b-ionone 1647 C13H20O2 208 1634 3-Hydroxy-5,6-dihydro-b-ionone 1609 C13H22O2 210 1635 (E)-b-Santalol 1680 C15H24O 220 1636 o-Cymene 976 C10H14 134 1637 Methyl 11-methyltridecanoate 1668 C15H30O2 242 1638 Libocedrol 2326 C22H30O4 358 1639 Aristol-1(10)-en-12-ol 1712 C15H24O 220 1640 Costunolide 1914 C15H20O2 232 1641 7-Hydroxyeudesm-4-en-6-one 1703 C15H24O2 236 1642 Aristol-1(10)-en-12-al 1704 C15H22O 218 1643 Methyl 10-methyldodecanoate 1575 C14H28O2 228 1644 Dotriacontane 3200 C32H66 450 1645 Eudesma-4(15),7(11),9-trien-12- 1971 C15H18O2 230 olide 1646 Isogermafurenolide 1867 C15H20O2 232 1647 Chloranthalactone A 1941 C15H16O2 228 1648 Ethyl decanoate 1375 C12H24O2 200 1649 Ethyl palmitate 1954 C18H36O2 284 1650 7,11-Epoxymegastigm-5-en-9-one 1551 C13H20O2 208 1651 Neoiso-isopulegol 1164 C10H18O 154 1652 b-Ionol 1400 C13H22O 194 1653 8-Hydroxylinalyl tiglate 1760 C15H24O3 252 1654 (Z)-Methyl 4-(geranyloxy)- 2334 C20H26O3 314 cinnamate 1655 (E)-Methyl 4-(geranyloxy)- 2461 C20H26O3 314 cinnamate 1656 Tetradecyl acetate 1775 C16H32O2 256 1657 Benzyl 3-methylbutyrate 1366 C12H16O2 192 1658 Benzyl 2-methylbutyrate 1360 C12H16O2 192 1659 Decanoic acid 1347 C10H20O2 172 1660 n-Octanoic acid 1156 C8H16O2 144 1661 Dihydromayurone 1591 C14H22O 206 1662 Ethyl hexadecanoate 1990 C18H36O2 284 1663 8-Hydroxylinalyl propionate 1551 C13H22O3 226 1664 4-Acetoxy-3-methoxyacetophenone 1434 C11H12O4 208 1665 o-Anisaldehyde 1202 C8H8O2 136 1666 2-Octanone 964 C8H16O 128 1667 (E)-trans-Bergamotol 1680 C15H24O 220 1668 Methyl 3-methylpentanoate 853 C7H14O2 130 1669 Methyl 3,7-dimethyloctanoate 1207 C11H22O2 186 1670 Methyl 4-methylhexanoate 974 C8H16O2 144 1671 Muurolan-4,7-oxide 1480 C15H26O 222 1672 cis-Totarol 2252 C20H30O 286 1673 4-Butyl-3-methyl-g-butanolide 1252 C9H16O2 156 1674 Isosaccogynol 1740 C15H22O 218 1675 Isosaccogynone 1744 C15H20O 216 1676 Taylorione 1617 C15H22O 218 1677 2-a-Acetoxy-11-methoxyamorpha- 1846 C18H28O3 292 4,7-diene 1678 2-a-Acetoxyamorpha-4,7(11)-dien- 1963 C17H24O3 276 8-one 1679 Neryl formate 1265 C11H18O2 182 1680 Geranyl butyrate 1534 C15H26O2 238 1681 Nerylpropionate 1451 C14H24O2 224 1682 Geranyl tiglate 1670 C15H24O2 236 1683 2-Methylbutyl angelate 1130 C10H18O2 170 1684 3-Methylbutyl angelate 1125 C10H18O2 170 1685 Methallyl angelate 1040 C9H14O2 154 1686 3-Methylbutyl methacrylate 1018 C9H16O2 156 1687 3-Methylbutyl isobutyrate 994 C9H18O2 158 1688 3-Methylpentyl isobutyrate 1095 C10H20O2 172 1689 3-Methylpentyl angelate 1230 C11H20O2 184 1690 Butyl angelate 1065 C9H16O2 156 1691 10-Acetoxy-4-oplopanone 1874 C17H28O3 280 1692 Butyl benzoate 1556 C11H14O2 178 1693 Propyl benzoate 1347 C10H12O2 164 1694 Phenylacetonitrile 1085 C8H7N 117 1695 Hexadecyl acetate 1847 C18H36O2 284 1696 Octadecyl acetate 2084 C20H40O2 312 1697 Octadecanal 2012 C18H36O 268 1698 Hexadecanal 1782 C16H32O 240 1699 Heptacosane 2700 C27H56 380 1700 Docosanal 2338 C22H44O 324 1701 cis-b-Elemene 1381 C15H24 204 1702 Eicosanal 2170 C20H40O 296 1703 1-Methyl-3-(2-oxopropyl)-4-(1- 1409 C13H20O 192 methylethenyl)-cyclohexene 1704 Ginsenol 1621 C15H26O 222 1705 4-n-Propylanisol 1254 C10H14O 150 1706 n-Decyl acetate 1390 C12H24O2 200 1707 Dimethyl-tetrasulfide 1181 C2H6S4 158 1708 Dimethyl trisulfide 942 C2H6S3 126 1709 S,S-Dimethyl dithiocarbonate 935 C3H6OS2 122 1710 2,5-Diethyltetrahydrofuran 875 C8H16O 128 1711 Neoiso-isopulegol acetate 1366 C12H20O2 196 1712 Methyl 2-hydroxy-4-methoxy-6- 1555 C10H12O4 196 methylbenzoate 1713 1-Octen-3-yl 3-methylbutyrate 1315 C13H24O2 212 1714 1-Octen-3-yl 2-methylbutyrate 1310 C13H24O2 212 1715 Oct-1-en-3-yl butyrate 1266 C12H22O2 198 1716 1-Octen-3-yl isobutyrate 1223 C12H22O2 198 1717 l-Octen-3-yl propanoate 1181 C11H20O2 184 1718 14-Hydroxy-4,5-dihydro-b- 1692 C15H26O 222 caryophyllene 1719 14-Hydroxy-b-caryophyllene 1656 C15H24O 220 1720 4,5-Dihydro-b-caryophyllen-14-al 1610 C15H24O 220 (Isomer 1) 1721 4,5-Dihydro-b-caryophyllen-14-al 1621 C15H24O 220 (Isomer 2) 1722 4-Desmethylcaryophyll-8(14)-en-5- 1521 C14H22O 206 one 1723 Isocaryophyllen-14-al (b-Betulenal) 1630 C15H22O 218 1724 1-Angeloyloxyverbenone 1694 C15H20O3 248 1725 4-Hydroxy-2-methylacetophenone 1254 C9H10O2 150 1726 7-epi-1,2-Dehydrosesquicineole 1460 C15H24O 220 1727 1,2-Dimethoxybenzene (Veratrol) 1117 C8H10O2 138 1728 (E)-Isoelemicin 1614 C12H16O3 208 1729 (Z)-Isoelemicin 1559 C12H16O3 208 1730 1,2,4-Trimethoxybenzene 1330 C9H12O3 168 1731 p-Menth-1-en-9-al (Isomer 1) 1188 C10H16O 152 1732 p-Menth-1-en-9-al (Isomer 2) 1190 C10H16O 152 1733 (Methoxymethyl)-benzene 964 C8H10O 122 1734 1,4-Dimethoxybenzene 1132 C8H10O2 138 1735 6,10,14-Trimethylpentadecan-2-one 1817 C18H36O 268 1736 (Z)-a-Damascone 1343 C13H20O 192 1737 Lilac alcohol (2R,2′R,5′S) 1210 C10H18O2 170 1738 Lilac alcohol (2R,2′S,5′S)) 1196 C10H18O2 170 1739 Lilac alcohol (2S,2′S,5′S) 1185 C10H18O2 170 1740 Lilac aldehyde (2R,2′R,5′S) 1146 C10H16O2 168 1741 Lilac aldehyde (2R,2′S,5′S) 1133 C10H16O2 168 1742 Lilac aldehyde (2S,2′S,5′S) 1124 C10H16O2 168 1743 Methyl citronellate 1245 C11H20O2 184 1744 Myli-4(15)-ene 1418 C15H22 202 1745 Maali-4(15)-en-1-ol 1624 C15H24O 220 1746 (E)-Taylopyran 1530 C15H22O 218 1747 7-epi-Bourbon-3-ene 5,11-oxide 1473 C15H22O 218 1748 Mylian-3-one 1593 C15H22O 218 1749 Myli-4(15)-en-3-one 1610 C15H20O 216 1750 5,5-Dimethyl-1-vinylbicyclo- 931 C10H16 136 [2.1.1] hexane 1751 Cara-2,4-diene 900 C10H14 134 1752 Eudesm-4(15)en-6-one 1616 C15H24O 220 1753 Eudesm-4-en-6-one 1605 C15H24O 220 1754 Guaia-3,9-diene 5,11-oxide 1519 C15H22O 218 1755 Guaia-3,10(14)-diene 5,11-oxide 1555 C15H22O 218 1756 3-Ethylacetophenone 1260 C10H12O 148 1757 4-Ethylacetophenone 1240 C10H12O 148 1758 (6Z,8E)-Megastigma-4,6,8-trien-3- 1553 C13H18O 190 one 1759 (E,E)-Megastigma-4,6,8-trien-3-one 1598 C13H18O 190 1760 Aromadendra-1(10),4(15)-diene 1506 C15H22 202 1761 Perfora-1,7-diene 1543 C15H24 204 1762 Guaia-1(10),11-diene 1516 C15H24 204 1763 Guaia-9,11-diene 1522 C15H24 204 1764 Norpinguisone 1600 C14H18O2 218 1765 Methyl norpinguisonate 1776 C15H18O4 262 1766 Bisabola-1,3,5,7(14)-tetraene 1484 C15H22 202 1767 Lemnalone 1611 C15H22O 218 1768 Methyl 2,4-Dimethoxy-6- 1588 C11H14O4 210 methylbenzoate 1769 Methyl 6-Methoxy-2-methyl-3,4- 1661 C11H12O5 224 methylendioxybenzoate 1770 Methyl 6-Hydroxy-2-methyl-3,4- 1640 C10H10O5 210 methylendioxybenzoate 1771 Methyl 3,4,6-trimethoxy-2- 1705 C12H16O5 240 methylbenzoate 1772 4-Methoxyphenylacetaldehyde 1255 C9H10O2 150 1773 Aromadendra-4,9-diene 1534 C15H22 202 1774 Aromadendra-1(10),4-diene 1462 C15H22 202 1775 Aromadendra-4,10(14)-diene 1440 C15H22 202 1776 5,6-Dihydro-1,4-dimethylazulene 1428 C12H14 158 1777 3,4,5,6-Tetrahydro-1,4- 1246 C12H16 160 dimethylazulene 1778 2,3,3a,4,5,6-Hexahydro-1,4- 1447 C12H18O 178 dimethylazulen-3-ol 1779 3a-Acetoxyamorpha-4,7(11)-diene 1780 C17H26O2 262 1780 Amorpha-2,4,7(11)-triene 1449 C15H22 202 1781 Amorpha-4,7(11)-dien-2-one 1645 C15H22O 218 1782 2a-Acetoxyamorpha-4,7(11)-diene 1796 C17H26O2 262 1783 2b-Acetoxyamorpha-4,7(11)-diene 1722 C17H26O2 262 1784 9a-Hydroxyamorpha-4,7(11)-diene 1680 C15H24O 220 1785 7b-Hydroxyamorpha-4,11-diene 1615 C15H24O 220 1786 3a-Hydroxyamorpha-4,7(11)-diene 1665 C15H24O 220 1787 Amorpha-4,7(11)-dien-3-one 1677 C15H22O 218 1788 Eudesma-4,11-dien-9-one 1649 C15H22O 218 1789 2,8-Epoxyamorpha-4,7(11)-diene 1597 C15H22O 218 1790 5,9-Epoxyamorpha-3,7(11)-diene 1594 C15H22O 218 1791 n-Tridecanal 1493 C13H26O 198 1792 (E)-Non-2-en-4-one 306 1098 C9H16O 140 1793 (E)-3-Methylnon-2-en-4-one 1190 C10H18O 154 1794 Isotheaspirane (Isomer 1) 1263 C13H22O 194 1795 Isotheaspirane (Isomer 1) 1279 C13H22O 194 1796 Chiloscyphone 1576 C15H22O 218 1797 2-Hydroxy-3,5-dimethoxy-9,10- 2251 C16H16O3 256 dihydrophenanthrene 1798 4,5-Dihydroxy-3-methoxy-9,10- 2330 C15H14O3 242 dihydrophenanthrene 1799 Isozierene 1556 C15H22 202 1800 Isogermacrene A 1502 C15H24 204 1801 Iso-b-elemene 1359 C15H24 204 1802 n-Decyl butanoate 1567 C14H28O2 228 1803 g-Palmitolactone 2081 C16H30O2 254 1804 n-Octyl butanoate 1371 C12H24O2 200 1805 Benzyl butanoate 1313 C11H14O2 178 1806 n-Butyl butyrate 970 C8H16O2 144 1807 n-Heptyl butanoate 1270 C11H22O2 186 1808 2-Phenylethyl butyrate 1412 C12H16O2 192 1809 Ethyl 2-phenylhexanoate 1617 C14H20O2 220 1810 Methyl 4-hydroxybenzoate 1414 C8H8O3 152 1811 n-Propyl 4-hydroxybenzoate 1584 C10H12O3 180 1812 n-Octyl hexanoate 1567 C14H28O2 228 1813 11-b-Hydroxykauren-15-a-yl acetate 2459 C22H34O3 346 1814 a-Campholenic acid 1304 C10H16O2 168 1815 5-Acetoxybornan-2-one 1399 C12H18O3 210 1816 n-Heptadecanal 1908 C17H34O 254 1817 Ventricos-7(13)-ene 1357 C15H24 204 1818 Helminthogermacrene 1503 C15H24 204 1819 allo-Aromadendra-4(15),10(14)- 1457 C15H22 202 diene 1820 Methyl 3-phenylpropanoate 1242 C10H12O2 164 1821 Nepetalactone (Isomer 1) 1331 C10H14O2 166 1822 (all-E)-Geranylcitronellol 2160 C20H36O 292 1823 Cyclooctatetraene 837 C8H8 104 1824 4-(4-Hydroxyphenyl)-butan-2-ol 1518 C10H14O2 166 1825 Lowry's phenol 1684 C12H16O4 224 1826 Platyphyllol 1588 C12H16O4 224 1827 Eugenitine 1944 C12H12O4 220 1828 Isoeugenitine 1963 C12H12O4 220 1829 Dihydrocolumellarine 1889 C15H22O2 234 1830 Myltaylenol 1727 C15H24O 220 1831 a-Gorgonene 1490 C15H24 204 1832 Aromadendra-4(15),10(14)dien-1- 1579 C15H22O 218 ol 1833 10-epi-Dihydroagarofuran 1520 C15H26O 222 1834 3,7-Dimethyl-3,7-dihydroxyoct-1- 1198 C10H20O2 172 ene 1835 Agarospirol 1635 C15H26O 222 1836 10a-Hydroxy-12-prenylguai-11-ene 2111 C20H34O 290 1837 5-Formyl-2-hydroxy-(3- 1617 C12H14O3 206 methylbutyro)-phenone 1838 4-Hydroxybenzaldehyde 1316 C7H6O2 122 1839 1,3,5-Trimethyl-1,3,5-triazin-2,4,6- 1327 C6H9O3N3 171 trione 1840 5-Formyl-2-hydroxy-(3-hydroxy-3- 1660 C12H14O4 222 methylbutyro)-phenone 1841 Octadecanoic acid 2182 C18H36O2 284 1842 Longipinanol, high temp. 1563 C15H26O 222 1843 Artemiseol 970 C10H16O 152 1844 a-Cyclocitral 1103 C10H16O 152 1845 (3E,5Z)-Undeca-1,3,5-triene (Isomer 1133 C11H18 150 2) 1846 Undeca-1,3,5-triene (Isomer 1) 1117 C11H18 150 1847 4-(4-Methoxyphenyl)-butan-2-one 1453 C11H14O2 178 1848 Atranol 1511 C8H8O3 152 1849 Chloroatranol 1466 C8H703Cl 186 1850 Myrtenyl methyl ether 1145 C11H18O 166 1851 8,14-Cedrane oxide 1536 C15H24O 220 1852 Camphene hydrate 1143 C10H18O 154 1853 6-Camphenone 1082 C10H14O 150 1854 Desmethoxyencecalin 1617 C13H14O2 202 1855 Bisabola-1,3,5,7-tetraene 1554 C15H22 202 1856 Myltayl-4-ene 1383 C15H24 204 1857 Gorgon-11-en-4-ol 1617 C15H26O 222 1858 a-Taylorione 1586 C15H22O 218 1859 Taylocyclan 1477 C15H22O 218 1860 Taynudol 1709 C15H22O 218 1861 Taylofuran 1635 C15H24O2 236 1862 3-Acetoxytaylorione 1918 C17H24O3 276 1863 Copalol 2265 C20H34O 290 1864 3a-Acetoxybicyclogermacrene 1769 C17H26O2 262 1865 Plagiooxide 1420 C15H26O 222 1866 Gymnomitr-3(15)-en-5b-ol 1653 C15H24O 220 1867 5b-Acetoxy-gymnomitr-3(15)-ene 1758 C17H26O2 262 1868 4b,5b-Diacetoxygymnomitr-3(15)- 1943 C19H28O4 320 ene 1869 15-Acetoxygymnomitr-3-ene 1797 C17H26O2 262 1870 3,15-b-Epoxy-4b- 1875 C17H26O3 278 acetoxygymnomitrane 1871 3,15-a-Epoxy-4b- 1887 C17H26O3 278 acetoxygymnomitrane 1872 Iso-a-humulene 1474 C15H24 204 1873 cis-Anethol 1230 C10H12O 148 1874 Cadina-4,11-dien-15-al 1704 C15H22O 218 1875 Cadina-4,11-dien-15-ol 1713 C15H26O 222 1876 a-Barbatenal 1659 C15H22O 218 1877 15-Nor-3-gymnomitrone 1609 C14H22O 206 1878 Bergaptene 2023 C12H8O4 216 1879 Peucedanin 2243 C15H14O4 258 1880 syn-Copalol 2165 C20H34O 290 1881 Melanene 1455 C15H24 204 1882 Panaxene 1312 C15H24 204 1883 Panaginsene 1336 C15H24 204 1884 Iso-g-bisabolene 1523 C15H24 204 1885 Viscida-4,9,14-triene 1862 C20H32 272 1886 Trichodiene 1523 C15H24 204 1887 2-Methyl-3-(4-methoxyphenyl)- 1324 C11H14O 162 prop-2-ene 1888 Gymnomitr-3(15)-en-12-oic acid 1790 C15H22O2 234 1889 12-Acetoxygymnomitr-3(15)-ene 1795 C17H26O2 262 1890 Gymnomitr-3(15)-en-12-al 1627 C15H22O 218 1891 Scapanol 1586 C15H26O 222 1892 Hydroxycitronellal 1263 C10H20O2 172 1893 2-(2-Ethoxyethoxy)-ethanol 985 C6H14O3 134 1894 Di-(2-hydroxypropyl)-ether 1003 C6H14O3 134 1895 Benzyl propionate 1231 C10H12O2 164 1896 2-Methyl-3-(4-isopropylphenyl)- 1433 C13H18O 190 propanal 1897 (Z)-b-Curcumen-12-ol 1732 C15H24O 120 1898 (Z)-b-Phenylethyl cinnamate 2006 C17H16O2 152 1899 (E)-b-Phenylethyl cinnamate 1123 C17H16O2 252 1900 Phenylethyl benzoate 1815 C15H14O2 126 1901 Phenyl ethyl phenylacetate 1868 C16H16O2 240 1902 Phenyl ethyl propionate 1468 C11H14O2 178 1903 2-(4-Methoxyphenyl)-5-methoxy- 2237 C16H16O3 256 2,3-dihydrobenzo[b]furan 1904 (Z)-Coriandrin 1234 C12H15ONS2 153 1905 (Z)-Coridrin 1708 C10H9ONS 191 1906 (E)-Coridrin 1784 C10H9ONS 191 1907 2-Methylene-6,6-dimethylcyclohex- 1092 C10H14O 150 3-ene-1-carbaldehyde 1908 1-p-Menthan-8-thiol 1196 C10H20S 172 1909 1-p-Menthen-8-thiol 1279 C10H18S 170 1910 5,5-Dimethylcyclohex-2-en-1,4- 1002 C8H10O2 138 dione 1911 Neoisomenthol 1176 C10H20O 156 1912 Menth-2-en-1,4-diol 1269 C10H18O2 170 1913 Carvone hydrate 1388 C10H16O2 168 1914 Carvone hydrate acetate 1528 C12H18O3 210 1915 8-Hydroxylinalyl isobutyrate 1588 C14H24O3 240 1916 Lyral 1637 C13H22O2 210 1917 Lyral (Isomer) 1625 C13H22O2 210 1918 2-(4-tert-butylbenzyl)-propione 1501 C14H20O 204 aldehyde 1919 Methyl 2-octynoate 1177 C9H14O2 154 1920 Caparapidiol 1686 C15H28O2 240 1921 Jaeschkeanadiol 1754 C15H26O2 238 1922 2,8-Epithio-cis-p-menthane 1242 C10H18S 170 1923 Gorgona-1,4(15),11-triene 1426 C15H22 202 1924 Aromadendra-1(10),3-diene 1509 C15H22 202 1925 8-Hydroxylinalyl 2-methylbutyrate 1688 C15H26O3 254 1926 trans-Pinane 951 C10H18 138 1927 4b-Acetoxygymnomitr-3(15)-ene 1739 C17H26O2 262 1928 1,8-Dimethyl-3-ethyl-2,9- 1344 C11H16O3 196 dioxabicyclo[3.3.1]non-7-en-6-one 1929 2,6-Diethyl-2,3-dihydro-4H-pyran- 1221 C9H14O2 154 4-one 1930 Frontaline 907 C8H14O2 142 1931 endo-Brevicomin 1039 C9H16O2 156 1932 cis-Pinane 963 C10H18 138 1933 Chalcograne (Isomer 1) 1051 C9H16O 140 1934 Chalcograne (Isomer 2) 1055 C9H16O 140 1935 Lineatine 1102 C10H16O2 168 1936 Methyl n-propyl trisufide 1121 C4H10S3 154 1937 (E)n-Propyl 1-propenyl disulfide 1063 C6H12S2 148 1938 Di-n-propyl trisulfide 1302 C6H14S3 182 1939 Methyl n-propyl disulfide 900 C4H10S2 122 1940 Di-n-propyl disulfide 1081 C6H14S2 150 1941 Di-n-propyl tetrasulfide 1558 C6H14S4 214 1942 5-Pentyl-3,4,5-trimethyl-5H-furan-2- 1474 C12H20O2 196 one 1943 Plagiochilline T 1665 C15H20O 216 1944 Plagiochilline U 1625 C15H22O 218 1945 5-Methylcyclohex-2-en-1-one 935 C7H10O 110 1946 3-Ethylcyclohexanone 1020 C8H14O 126 1947 Methyl 3-ethyl-4-methylpentanoate 1021 C9H18O2 158 1948 2,4-Diethyloct-1-ene 1106 C12H24 168 1949 Methyl trans-Dihydrojasmonate 1623 C13H22O3 226 1950 cis-Methyl dihydrojasmonate 1651 C13H22O3 226 1951 1,7-Dioxaspiro[5.5]undecane 1108 C9H16O2 156 1952 (2Z,4E)-Methyl abscisate 2076 C16H22O4 278 1953 (2Z,4E)-Methyl phaseate 2141 C16H22O5 294 1954 (2E,4E)-Methyl abscisate 2164 C16H22O4 278 1955 Pityol 945 C8H16O2 144 1956 6-Ethyl-2-methyl-2,3-dihydro-4H- 1117 C8H12O2 140 pyran-2-one 1957 n-Nonyl acetate 1283 C11H22O2 186 1958 4-epi-Maaliol 1549 C15H26O 222 1959 Plagiochiline H 1807 C17H24O3 276 1960 5-Methyloctahydrofuro [3,2- 1028 C9H16O2 156 b]oxepine 1961 Methyl 2-hydroxyhexanoate 993 C7H14O3 146 1962 Methyl 2-hydroxytetradecanoate 1838 C15H30O3 258 1963 Seudenol 941 C7H12O 112 1964 2,8-Dimethyl-1,7- 1121 C11H20O2 184 dioxaspiro[5.5]undecane (Isomer 1) 1965 2,8-Dimethyl-1,7- 1189 C11H20O2 184 dioxaspiro[5.5]undecane (Isomer 2) 1966 4-Methyl-2-buten-4-olide 869 C5H6O2 98 1967 Methyl 2-methyltetradecanoate 1758 C16H32O2 256 1968 Methyl 3-methylpentanoate 840 C7H14O2 130 1969 Methyl 2-methylundecanoate 1509 C13H26O2 214 1970 Methyl 2-methyldodecanoate 1550 C14H28O2 228 1971 Methyl 2-hydroxyisopentanoate 845 C6H12O3 132 1972 Methyl 2-hydroxypentanoate 894 C6H12O3 132 1973 4a-Methyloctahydronaphthalen-2- 1369 C11H18O 166 one 1974 Methyl madelate 1245 C9H10O3 166 1975 Methyl 2-hydroxydodecanoate 1627 C13H26O3 230 1976 1-Phenylethanol 1037 C8H10O 122 1977 2,3,5-Trimethylvalerolactone 1158 C8H14O2 142 1978 10-Methyldecalin-2,7-dione 1520 C11H16O2 180 1979 6-Hexyl-5,6-dihydropyran-2-one 1551 C11H18O2 182 1980 Methyl 2-methylpentadecanoate 2195 C17H34O2 270 1981 2,3-Epoxycinnamyl alcohol 1309 C9H10O2 150 1982 Methyl 2-methylhexadecanoate 1972 C18H36O2 284

An exemplary therapeutic compound conforming with any of the disclosed embodiments may comprise for instance a compound including at least two of delta-9-tetrahydrocannabinol or tetrahydrocannabinolic acid, and cannabidiol and optionally at least one of the listed terpenes Still further an exemplary therapeutic compound conforming with any of the disclosed embodiments may comprise for instance a compound including 20 mg of delta-9-tetrahydrocannabinol and 10 mg of cannabidiol preferably administered every 6-8 hours as needed. Still further an exemplary therapeutic compound conforming with any of the disclosed embodiments may comprise for instance a compound including 10 mg of delta-9-tetrahydrocannabinol and 5 mg of cannabidiol preferably administered every 6-8 hours as needed. Still further an exemplary therapeutic compound conforming with any of the disclosed embodiments may comprise for instance a compound including 20 mg of delta-9-tetrahydrocannabinol and 20 mg of cannabidiol preferably administered every 6-8 hours as needed. Still further an exemplary therapeutic compound conforming with any of the disclosed embodiments may comprise for instance a compound including 10 mg of delta-9-tetrahydrocannabinol and 10 mg of cannabidiol preferably administered every 6-8 hours as needed. Still further an exemplary therapeutic compound conforming with any of the disclosed embodiments may comprise for instance a compound including 15 mg of delta-9-tetrahydrocannabinol and 10 mg of cannabidiol preferably administered every 6-8 hours as needed.

Further, enumerated embodiments are described below.

-   -   Embodiment 1. A pharmaceutical composition comprising: (a)         tetrahydrocannabinol (THC) and cannabidiol (CBD) in a THC:CBD         ratio of from 1:1.5 to 3:1 by weight; and (b) one or more         terpenes listed in Table 1.     -   Embodiment 2. The pharmaceutical composition of embodiment 1,         wherein the THC:CBD ratio is about: 1:1.5, 1:1.4, 1:1.3, 1:1.2,         1:1.1, 1:1, 1.1:1, 1.2:1, 1.3:1, 1.4:1, 1.5:1, 1.6:1, 1.7:1,         1.8:1, 1.9:1, 2:1, 2.1:1, 2.2:1, 2.3:1, 2.4:1, 2.5:1, 2.6:1,         2.7:1, 2.8:1, 2.9:1, or 3:1.     -   Embodiment 3. The pharmaceutical composition of embodiment 1,         wherein the THC:CBD ratio is from 1.5:1 to 2:1.     -   Embodiment 4. The pharmaceutical composition of embodiment 1,         wherein the THC:CBD ratio is about 1.5:1.     -   Embodiment 5. The pharmaceutical composition of any one of         embodiments 1-4, wherein the pharmaceutical composition         comprises: 1-50 mg, 5-40 mg, 7.5-30 mg, 10-20 mg, or 12.5-17.5         mg tetrahydrocannabinol (THC) per dose.     -   Embodiment 6. The pharmaceutical composition of any one of         embodiments 1-4, wherein the pharmaceutical composition         comprises about: 1 mg, 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15         mg, 17.5 mg, 20 mg, 25 mg, 30 mg, 35 mg, 40 mg, 45 mg, or 50 mg         tetrahydrocannabinol (THC) per dose.     -   Embodiment 7. The pharmaceutical composition of any one of         embodiments 1-4, wherein the pharmaceutical composition         comprises about 10-20 mg tetrahydrocannabinol (THC) per dose.     -   Embodiment 8. The pharmaceutical composition of any one of         embodiments 1-4, wherein the pharmaceutical composition         comprises about 15-20 mg tetrahydrocannabinol (THC) per dose.     -   Embodiment 9. The pharmaceutical composition of any one of         embodiments 1-8, wherein the pharmaceutical composition         comprises: 1-35 mg, 2.5-30 mg, 5-25 mg, 6-14 mg, 10-12 mg         cannabidiol (CBD) per dose.     -   Embodiment 10. The pharmaceutical composition of any one of         embodiments 1-8, wherein the pharmaceutical composition         comprises about: 1 mg, 1.5 mg, 2 mg, 2.5 mg, 3 mg, 4 mg, 5 mg, 6         mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg,         17.5 mg, 20 mg, 22.5 mg, 25 mg, 27.5 mg, or 30 mg cannabidiol         (CBD) per dose.     -   Embodiment 11. The pharmaceutical composition of any one of         embodiments 1-8, wherein the pharmaceutical composition         comprises 6-14 mg cannabidiol (CBD).     -   Embodiment 12. The pharmaceutical composition of any one of         embodiments 1-8, wherein the pharmaceutical composition         comprises 10-12 mg cannabidiol (CBD).     -   Embodiment 13. The pharmaceutical composition of any one of         embodiments 1-12, wherein the one or more terpenes comprise         β-myrcene, β-caryophyllene, ocimene, α-pinene, α-humulene,         linalool, p-cymene, camphene, cis-nerolidol, terpinolene,         isopulegol, caryophyllene oxide, δ-limonene, geraniol, guaiol,         α-bisabolol, 3-carene, β-pinene, γ-terpinene, or a combination         thereof.     -   Embodiment 14. The pharmaceutical composition of any one of         embodiments 1-12, wherein the one or more terpenes comprise         β-myrcene, β-caryophyllene, ocimene, α-pinene, α-humulene,         linalool, p-cymene, and camphene.     -   Embodiment 15. The pharmaceutical composition of any one of         embodiments 1-12, wherein the one or more terpenes comprise         β-myrcene, β-caryophyllene, ocimene, α-pinene, and α-humulene.     -   Embodiment 16. The pharmaceutical composition of any one of         embodiments 1-12, wherein the one or more terpenes comprise         β-myrcene, ocimene, cis-nerolidol, terpinolene, isopulegol,         caryophyllene oxide, δ-limonene, geraniol, guaiol, and         α-bisabolol.     -   Embodiment 17. The pharmaceutical composition of any one of         embodiments 1-12, wherein the one or more terpenes comprise         β-myrcene, ocimene, cis-nerolidol, terpinolene, isopulegol,         caryophyllene oxide, δ-limonene, geraniol, guaiol, α-bisabolol,         and 3-carene.     -   Embodiment 18. The pharmaceutical composition of any one of         embodiments 1-12, wherein the one or more terpenes comprise         β-myrcene, β-caryophyllene, ocimene, α-humulene, linalool,         ρ-cymene, camphene, 3-carene, β-pinene, and γ-terpinene.     -   Embodiment 19. The pharmaceutical composition of any one of         embodiments 1-12, wherein the one or more terpenes comprise         β-myrcene, β-caryophyllene, ocimene, α-pinene, α-humulene,         linalool, ρ-cymene, camphene, 3-carene, β-pinene, and         γ-terpinene.     -   Embodiment 20. The pharmaceutical composition of any one of         embodiments 1-19, wherein the one or more terpenes comprise         β-myrcene, and wherein the pharmaceutical composition comprises         1-100 mg, 20-80 mg, 30-60 mg, 40-50 mg, 1-10 mg, 1.5-7.5 mg, or         2-5 mg of β-myrcene per dose.     -   Embodiment 21. The pharmaceutical composition of any one of         embodiments 1-19, wherein the one or more terpenes comprise         β-myrcene, and wherein the pharmaceutical composition comprises         about: 1 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7         mg, 1.8 mg, 1.9 mg, 2 mg, 2.1 mg, 2.2 mg, 2.3 mg, 2.4 mg, 2.5         mg, 2.6 mg, 2.7 mg, 2.8 mg, 2.9 mg, 3 mg, 3.1 mg, 3.2 mg, 3.3         mg, 3.4 mg, 3.5 mg, 3.6 mg, 3.7 mg, 3.8 mg, 3.9 mg, 4 mg, 4.5         mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, or 10 mg of β-myrcene per         dose.     -   Embodiment 22. The pharmaceutical composition of any one of         embodiments 1-19, wherein the one or more terpenes comprise         β-myrcene, and wherein the pharmaceutical composition comprises         about: 25 mg, 30 mg, 35 mg, 40 mg, 45 mg, 50 mg, 55 mg, or 60 mg         of β-myrcene per dose.     -   Embodiment 23. The pharmaceutical composition of any one of         embodiments 1-19, wherein the one or more terpenes comprise         β-myrcene, and wherein the pharmaceutical composition comprises         1.5-7.5 mg of β-myrcene per dose.     -   Embodiment 24. The pharmaceutical composition of any one of         embodiments 1-19, wherein the one or more terpenes comprise         β-myrcene, and wherein the pharmaceutical composition comprises         30-60 mg of β-myrcene per dose.     -   Embodiment 25. The pharmaceutical composition of any one of         embodiments 1-24, wherein the one or more terpenes comprise         β-caryophyllene, and wherein the pharmaceutical composition         comprises 1-20 mg, 2-10 mg, 2.5-5 mg, or 3-8 mg of         β-caryophyllene per dose.     -   Embodiment 26. The pharmaceutical composition of any one of         embodiments 1-24, wherein the one or more terpenes comprise         β-caryophyllene, and wherein the pharmaceutical composition         comprises about 1 mg, 1.5 mg, 2 mg, 2.25 mg, 2.5 mg, 2.75 mg, 3         mg, 3.1 mg, 3.2 mg, 3.3 mg, 3.4 mg, 3.5 mg, 3.6 mg, 3.7 mg, 3.8         mg, 3.9 mg, 4 mg, 4.25 mg, 4.5 mg, 4.75 mg, 5 mg, 5.5 mg, 6 mg,         6.5 mg, 7 mg, 7.5 mg, 7.6 mg, 8 mg, 9 mg, 10 mg, 12.5 mg, 15 mg,         or 20 mg of β-caryophyllene per dose.     -   Embodiment 27. The pharmaceutical composition of any one of         embodiments 1-24, wherein the one or more terpenes comprise         β-caryophyllene, and wherein the pharmaceutical composition         comprises 2.5-5 mg of β-caryophyllene per dose.     -   Embodiment 28. The pharmaceutical composition of any one of         embodiments 1-27, wherein the one or more terpenes comprise         ocimene, and wherein the pharmaceutical composition comprises         1-20 mg, 2-10 mg, 2.3-4.7 mg, or 3-8 mg of ocimene per dose.     -   Embodiment 29. The pharmaceutical composition of any one of         embodiments 1-27, wherein the one or more terpenes comprise         ocimene, and wherein the pharmaceutical composition comprises         about 1 mg, 1.1 mg, 1.5 mg, 2 mg, 2.1 mg, 2.3 mg, 2.5 mg, 2.75         mg, 3 mg, 3.1 mg, 3.2 mg, 3.3 mg, 3.4 mg, 3.5 mg, 3.6 mg, 3.7         mg, 3.8 mg, 3.9 mg, 4 mg, 4.2 mg, 4.5 mg, 4.7 mg, 5 mg, 5.5 mg,         6 mg, 6.5 mg, 7 mg, 7.5 mg, 7.6 mg, 8 mg, 9 mg, 10 mg, 12.5 mg,         15 mg, or 20 mg of ocimene per dose.     -   Embodiment 30. The pharmaceutical composition of any one of         embodiments 1-27, wherein the one or more terpenes comprise         ocimene, and wherein the pharmaceutical composition comprises         2.3-4.7 mg of ocimene per dose.     -   Embodiment 31. The pharmaceutical composition of any one of         embodiments 1-30, wherein the one or more terpenes comprise         α-pinene, and wherein the pharmaceutical composition comprises         0.1-10 mg, 0.5-5 mg, or 1.1-2.1 mg of α-pinene per dose.     -   Embodiment 32. The pharmaceutical composition of any one of         embodiments 1-30, wherein the one or more terpenes comprise         α-pinene, and wherein the pharmaceutical composition comprises         about 0.1 mg, 0.2 mg, 0.3 mg, 0.4 mg, 0.5 mg, 0.6 mg, 0.7 mg,         0.8 mg, 0.9 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg,         1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 2.1 mg, 2.2 mg, 2.3 mg,         2.4 mg, 2.5 mg, 2.75 mg, 3 mg, 3.5 mg, 4 mg, 4.5 mg, 5 mg, 7.5         mg, or 10 mg of α-pinene per dose.     -   Embodiment 33. The pharmaceutical composition of any one of         embodiments 1-30, wherein the one or more terpenes comprise         α-pinene, and wherein the pharmaceutical composition comprises         1.1-2.1 mg of α-pinene per dose.     -   Embodiment 34. The pharmaceutical composition of any one of         embodiments 1-33, wherein the one or more terpenes comprise         α-humulene, and wherein the pharmaceutical composition comprises         0.1-5 mg, 0.5-3.5 mg, or 0.8-1.6 mg of α-humulene per dose.     -   Embodiment 35. The pharmaceutical composition of any one of         embodiments 1-33, wherein the one or more terpenes comprise         α-humulene, and wherein the pharmaceutical composition comprises         about 0.1 mg, 0.2 mg, 0.3 mg, 0.4 mg, 0.5 mg, 0.6 mg, 0.7 mg,         0.8 mg, 0.9 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg,         1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 2.1 mg, 2.2 mg, 2.3 mg,         2.4 mg, 2.5 mg, 2.6 mg, 2.7 mg, 2.8 mg, 2.9 mg, 3 mg, 3.1 mg,         3.2 mg, 3.5 mg, 4 mg, 4.5 mg, or 5 mg of α-humulene per dose.     -   Embodiment 36. The pharmaceutical composition of any one of         embodiments 1-33, wherein the one or more terpenes comprise         α-humulene, and wherein the pharmaceutical composition comprises         0.8-1.6 mg of α-humulene per dose.     -   Embodiment 37. The pharmaceutical composition of any one of         embodiments 1-36, wherein the one or more terpenes comprise         linalool, and wherein the pharmaceutical composition comprises         0.1-2 mg, 0.2-1.5 mg, or 0.3-0.9 mg of linalool per dose.     -   Embodiment 38. The pharmaceutical composition of any one of         embodiments 1-36, wherein the one or more terpenes comprise         linalool, and wherein the pharmaceutical composition comprises         about 0.1 mg, 0.2 mg, 0.3 mg, 0.4 mg, 0.5 mg, 0.6 mg, 0.7 mg,         0.8 mg, 0.9 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg,         1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, or 2 mg of linalool per dose.     -   Embodiment 39. The pharmaceutical composition of any one of         embodiments 1-36, wherein the one or more terpenes comprise         linalool, and wherein the pharmaceutical composition comprises         0.3-0.9 mg of linalool per dose.     -   Embodiment 40. The pharmaceutical composition of any one of         embodiments 1-39, wherein the one or more terpenes comprise         ρ-cymene, and wherein the pharmaceutical composition comprises         0.1-20 mg, 0.25-10 mg, 5-10 mg, or 0.5-0.9 mg of ρ-cymene per         dose.     -   Embodiment 41. The pharmaceutical composition of any one of         embodiments 1-39, wherein the one or more terpenes comprise         ρ-cymene, and wherein the pharmaceutical composition comprises         about 0.1 mg, 0.2 mg, 0.3 mg, 0.4 mg, 0.5 mg, 0.6 mg, 0.7 mg,         0.8 mg, 0.9 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg,         1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 2.5 mg, 3 mg, 4 mg, 5 mg,         5.5 mg, 6 mg, 6.5 mg, 6.75 mg, 7 mg, 7.1 mg, 7.2 mg, 7.3 mg, 7.4         mg, 7.5 mg, 8 mg, 9 mg, 10 mg, 12.5 mg, 15 mg or 20 mg of         ρ-cymene per dose.     -   Embodiment 42. The pharmaceutical composition of any one of         embodiments 1-39, wherein the one or more terpenes comprise         ρ-cymene, and wherein the pharmaceutical composition comprises         0.5-0.9 mg of ρ-cymene per dose.     -   Embodiment 43. The pharmaceutical composition of any one of         embodiments 1-42, wherein the one or more terpenes comprise         camphene, and wherein the pharmaceutical composition comprises         0.01-2 mg, 0.02-1 mg, 0.03-0.5 mg, or 0.05 to 0.15 mg of         camphene per dose.     -   Embodiment 44. The pharmaceutical composition of any one of         embodiments 1-42, wherein the one or more terpenes comprise         camphene, and wherein the pharmaceutical composition comprises         about 0.01 mg, 0.02 mg, 0.03 mg, 0.04 mg, 0.05 mg, 0.06 mg, 0.07         mg, 0.08 mg, 0.09 mg, 0.1 mg, 0.15 mg, 0.2 mg, 0.3 mg, 0.4 mg,         0.5 mg, 0.6 mg, 0.7 mg, 0.8 mg, 0.9 mg, 1 mg, 1.25 mg, 1.5 mg,         1.75 mg, or 2 mg of camphene per dose.     -   Embodiment 45. The pharmaceutical composition of any one of         embodiments 1-42, wherein the one or more terpenes comprise         camphene, and wherein the pharmaceutical composition comprises         0.05-0.15 mg of camphene per dose.     -   Embodiment 46. The pharmaceutical composition of any one of         embodiments 1-45, wherein the one or more terpenes comprise         cis-nerolidol, and wherein the pharmaceutical composition         comprises 0.5-20 mg, 1-10 mg, or 1.5 to 5 mg of cis-nerolidol         per dose.     -   Embodiment 47. The pharmaceutical composition of any one of         embodiments 1-45, wherein the one or more terpenes comprise         cis-nerolidol, and wherein the pharmaceutical composition         comprises about 0.5 mg, 0.6 mg, 0.7 mg, 0.8 mg, 0.9 mg, 1.0 mg,         1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg,         1.9 mg, 2 mg, 2.25 mg, 2.5 mg, 3 mg, 4 mg, 4.5 mg, 4.8 mg, 5 mg,         6 mg, 7 mg, 8 mg, 9 mg 10 mg, 15 mg, or 20 mg of cis-nerolidol         per dose.     -   Embodiment 48. The pharmaceutical composition of any one of         embodiments 1-45, wherein the one or more terpenes comprise         cis-nerolidol, and wherein the pharmaceutical composition         comprises 1.5-5 mg of cis-nerolidol per dose.     -   Embodiment 49. The pharmaceutical composition of any one of         embodiments 1-48, wherein the one or more terpenes comprise         terpinolene, and wherein the pharmaceutical composition         comprises 0.5-10 mg, 1-5 mg, or 1.2 to 3 mg of terpinolene per         dose.     -   Embodiment 50. The pharmaceutical composition of any one of         embodiments 1-48, wherein the one or more terpenes comprise         terpinolene, and wherein the pharmaceutical composition         comprises about 0.5 mg, 0.6 mg, 0.7 mg, 0.8 mg, 0.9 mg, 1.0 mg,         1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg,         1.9 mg, 2 mg, 2.25 mg, 2.5 mg, 3 mg, 4 mg, 4.5 mg, 4.8 mg, 5 mg,         6 mg, 7 mg, 8 mg, 9 mg 10 mg, 15 mg, or 20 mg of terpinolene per         dose.     -   Embodiment 51. The pharmaceutical composition of any one of         embodiments 1-48, wherein the one or more terpenes comprise         terpinolene, and wherein the pharmaceutical composition         comprises 1.2-3 mg of terpinolene per dose.     -   Embodiment 52. The pharmaceutical composition of any one of         embodiments 1-51, wherein the one or more terpenes comprise         isopulegol, and wherein the pharmaceutical composition comprises         0.1-5 mg, 0.5-3.5 mg, or 0.8 to 2.3 mg of isopulegol per dose.     -   Embodiment 53. The pharmaceutical composition of any one of         embodiments 1-51, wherein the one or more terpenes comprise         isopulegol, and wherein the pharmaceutical composition comprises         about 0.1 mg, 0.2 mg, 0.3 mg, 0.4 mg, 0.5 mg, 0.6 mg, 0.7 mg,         0.8 mg, 0.9 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg,         1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 2.3 mg, 2.5 mg, 3 mg, 3.5         mg, 4 mg, 4.5 mg, 4.8 mg, or 5 mg of isopulegol per dose.     -   Embodiment 54. The pharmaceutical composition of any one of         embodiments 1-51, wherein the one or more terpenes comprise         isopulegol, and wherein the pharmaceutical composition comprises         0.8-2.3 mg of isopulegol per dose.     -   Embodiment 55. The pharmaceutical composition of any one of         embodiments 1-54, wherein the one or more terpenes comprise         caryophyllene oxide, and wherein the pharmaceutical composition         comprises 0.1-5 mg, 0.5-3.5 mg, or 0.8 to 2.2 mg of         caryophyllene oxide per dose.     -   Embodiment 56. The pharmaceutical composition of any one of         embodiments 1-54, wherein the one or more terpenes comprise         caryophyllene oxide, and wherein the pharmaceutical composition         comprises about 0.1 mg, 0.2 mg, 0.3 mg, 0.4 mg, 0.5 mg, 0.6 mg,         0.7 mg, 0.8 mg, 0.9 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg,         1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 2.2 mg, 2.5 mg, 3         mg, 3.5 mg, 4 mg, 4.5 mg, 4.8 mg, or 5 mg of caryophyllene oxide         per dose.     -   Embodiment 57. The pharmaceutical composition of any one of         embodiments 1-54, wherein the one or more terpenes comprise         caryophyllene oxide, and wherein the pharmaceutical composition         comprises 0.8-2.2 mg of caryophyllene oxide per dose.     -   Embodiment 58. The pharmaceutical composition of any one of         embodiments 1-57, wherein the one or more terpenes comprise         δ-limonene, and wherein the pharmaceutical composition comprises         0.1-5 mg, 0.5-3.5 mg, or 0.8 to 1.6 mg of δ-limonene oxide per         dose.     -   Embodiment 59. The pharmaceutical composition of any one of         embodiments 1-57, wherein the one or more terpenes comprise         δ-limonene, and wherein the pharmaceutical composition comprises         about 0.1 mg, 0.2 mg, 0.3 mg, 0.4 mg, 0.5 mg, 0.6 mg, 0.7 mg,         0.8 mg, 0.9 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg,         1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 2.2 mg, 2.5 mg, 3 mg, 3.5         mg, 4 mg, 4.5 mg, 4.8 mg, or 5 mg of δ-limonene per dose.     -   Embodiment 60. The pharmaceutical composition of any one of         embodiments 1-57, wherein the one or more terpenes comprise         δ-limonene, and wherein the pharmaceutical composition comprises         0.8-1.6 mg of δ-limonene per dose.     -   Embodiment 61. The pharmaceutical composition of any one of         embodiments 1-60, wherein the one or more terpenes comprise         geraniol, and wherein the pharmaceutical composition comprises         0.1-3 mg, 0.2-1.5 mg, or 0.4 to 0.9 mg of geraniol per dose.     -   Embodiment 62. The pharmaceutical composition of any one of         embodiments 1-60, wherein the one or more terpenes comprise         geraniol, and wherein the pharmaceutical composition comprises         about 0.1 mg, 0.2 mg, 0.3 mg, 0.4 mg, 0.5 mg, 0.6 mg, 0.7 mg,         0.8 mg, 0.9 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg,         1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 2.2 mg, 2.5 mg, or 3 mg of         geraniol per dose.     -   Embodiment 63. The pharmaceutical composition of any one of         embodiments 1-60, wherein the one or more terpenes comprise         geraniol, and wherein the pharmaceutical composition comprises         0.4-0.9 mg of geraniol per dose.     -   Embodiment 64. The pharmaceutical composition of any one of         embodiments 1-63, wherein the one or more terpenes comprise         guaiol, and wherein the pharmaceutical composition comprises         0.1-5 mg, 0.2-3.5 mg, or 0.4 to 3.2 mg of guaiol per dose.     -   Embodiment 65. The pharmaceutical composition of any one of         embodiments 1-63, wherein the one or more terpenes comprise         guaiol, and wherein the pharmaceutical composition comprises         about 0.1 mg, 0.2 mg, 0.3 mg, 0.4 mg, 0.5 mg, 0.6 mg, 0.7 mg,         0.8 mg, 0.9 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg,         1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 2.2 mg, 2.4, 2.5 mg, 2.75,         3 mg, 3.2 mg, 3.5 mg, 4 mg, 4.5 mg, or 5 mg of guaiol per dose.     -   Embodiment 66. The pharmaceutical composition of any one of         embodiments 1-63, wherein the one or more terpenes comprise         guaiol, and wherein the pharmaceutical composition comprises         0.4-3.2 mg of guaiol per dose.     -   Embodiment 67. The pharmaceutical composition of any one of         embodiments 1-66, wherein the one or more terpenes comprise         α-bisobolol, and wherein the pharmaceutical composition         comprises 0.1-3 mg, 0.2-1.5 mg, or 0.3 to 0.7 mg of α-bisobolol         per dose.     -   Embodiment 68. The pharmaceutical composition of any one of         embodiments 1-66, wherein the one or more terpenes comprise         α-bisobolol, and wherein the pharmaceutical composition         comprises about 0.1 mg, 0.2 mg, 0.3 mg, 0.4 mg, 0.5 mg, 0.6 mg,         0.7 mg, 0.8 mg, 0.9 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg,         1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 2.2 mg, 2.5 mg, or         3 mg of α-bisobolol per dose.     -   Embodiment 69. The pharmaceutical composition of any one of         embodiments 1-66, wherein the one or more terpenes comprise         α-bisobolol, and wherein the pharmaceutical composition         comprises 0.3-0.7 mg of α-bisobolol per dose.     -   Embodiment 70. The pharmaceutical composition of any one of         embodiments 1-69, wherein the one or more terpenes comprise         3-carene, and wherein the pharmaceutical composition comprises         0.1-3 mg, 0.2-1.5 mg, or 0.4 to 0.9 mg of 3-carene per dose.     -   Embodiment 71. The pharmaceutical composition of any one of         embodiments 1-69, wherein the one or more terpenes comprise         3-carene, and wherein the pharmaceutical composition comprises         about 0.1 mg, 0.2 mg, 0.3 mg, 0.4 mg, 0.5 mg, 0.6 mg, 0.7 mg,         0.8 mg, 0.9 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg,         1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 2.2 mg, 2.5 mg, or 3 mg of         3-carene per dose.     -   Embodiment 72. The pharmaceutical composition of any one of         embodiments 1-69, wherein the one or more terpenes comprise         3-carene, and wherein the pharmaceutical composition comprises         0.4-0.9 mg of 3-carene per dose.     -   Embodiment 73. The pharmaceutical composition of any one of         embodiments 1-72, wherein the one or more terpenes comprise         β-pinene, and wherein the pharmaceutical composition comprises         0.1-5 mg, 0.3-3 mg, or 0.6 to 2.0 mg of β-pinene per dose.     -   Embodiment 74. The pharmaceutical composition of any one of         embodiments 1-72, wherein the one or more terpenes comprise         β-pinene, and wherein the pharmaceutical composition comprises         about 0.1 mg, 0.2 mg, 0.3 mg, 0.4 mg, 0.5 mg, 0.6 mg, 0.7 mg,         0.8 mg, 0.9 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg,         1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 2.2 mg, 2.4, 2.5 mg, 2.75,         3 mg, 3.2 mg, 3.5 mg, 4 mg, 4.5 mg, or 5 mg of β-pinene per         dose.     -   Embodiment 75. The pharmaceutical composition of any one of         embodiments 1-72, wherein the one or more terpenes comprise         β-pinene, and wherein the pharmaceutical composition comprises         0.6-2.0 mg of β-pinene per dose.     -   Embodiment 76. The pharmaceutical composition of any one of         embodiments 1-75, wherein the one or more terpenes comprise         γ-terpinene, and wherein the pharmaceutical composition         comprises 0.05-1.6 mg, 0.1-0.8 mg, or 0.2 to 0.4 mg of         γ-terpinene per dose.     -   Embodiment 77. The pharmaceutical composition of any one of         embodiments 1-75, wherein the one or more terpenes comprise         γ-terpinene, and wherein the pharmaceutical composition         comprises about 0.05 mg, 0.06 mg, 0.07 mg, 0.08 mg, 0.09 mg, 0.1         mg, 0.11 mg, 0.12 mg, 0.13 mg, 0.14 mg, 0.15 mg, 0.16 mg, 0.17         mg, 0.18 mg, 0.19 mg, 0.20 mg, 0.21 mg, 0.22 mg, 0.23 mg, 0.24         mg, 0.25 mg, 0.26 mg, 0.27 mg, 0.28 mg, 0.29 mg, 0.3 mg, 0.31         mg, 0.32 mg, 0.33 mg, 0.34 mg, 0.35 mg, 0.36 mg, 0.37 mg, 0.38         mg, 0.39 mg, 0.4 mg, 0.45 mg, 0.5 mg, 0.55 mg, 0.6 mg, 0.75 mg,         1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, or 1.6 mg of         γ-terpinene per dose.     -   Embodiment 78. The pharmaceutical composition of any one of         embodiments 1-75, wherein the one or more terpenes comprise         γ-terpinene, and wherein the pharmaceutical composition         comprises 0.2-0.4 mg of γ-terpinene per dose.     -   Embodiment 79. The pharmaceutical composition of any one of         embodiments 1-78, wherein the one or more terpenes comprise         β-myrcene, β-caryophyllene, ocimene, α-pinene, α-humulene, or a         combination thereof, and wherein the pharmaceutical composition         comprises about 30-60 mg of the β-myrcene, about 2.5-5 mg of the         β-caryophyllene, about 2.3-4.7 mg of the ocimene, about 1.1-2.1         mg of the α-pinene, about 0.8-1.6 mg of the α-humulene, or a         combination thereof per dose.     -   Embodiment 80. The pharmaceutical composition of any one of         embodiments 1-78, wherein the one or more terpenes comprise         β-myrcene, β-caryophyllene, ocimene, α-pinene, and α-humulene;         and wherein the pharmaceutical composition comprises about 30-60         mg of the β-myrcene, about 2.5-5 mg of the β-caryophyllene,         about 2.3-4.7 mg of the ocimene, about 1.1-2.1 mg of the         α-pinene, and about 0.8-1.6 mg of the α-humulene per dose.     -   Embodiment 81. The pharmaceutical composition of any one of         embodiments 1-80, wherein the pharmaceutical composition is         formulated as a liquid, a pill, a gel capsule, a vaporizable         liquid, a vaporizable solid, a transdermal ointment or salve, or         a transdermal patch.     -   Embodiment 82. The pharmaceutical composition of any one of         embodiments 1-80, wherein the pharmaceutical composition is         formulated as a liquid.     -   Embodiment 83. The pharmaceutical composition of embodiment 82,         wherein the liquid comprises citric acid, blue agave, glycerine,         one or more lorann oils, food coloring, or a combination         thereof.     -   Embodiment 84. The pharmaceutical composition of embodiment 82,         wherein the liquid comprises: (a) about 1% to 7% w/w citric         acid; (b) about 40% to 49% w/w blue agave; (c) about 40% to 49%         w/w glycerin; (d) about 0.1% to 1.5% w/w lorann oils; (e) about         0.01 to 0.4% food coloring; (f) or a combination thereof.     -   Embodiment 85. The pharmaceutical composition of embodiment 82,         wherein the liquid comprises: (a) about 1% to 7% w/w citric         acid; (b) about 40% to 49% w/w blue agave; (c) about 40% to 49%         w/w glycerin; (d) about 0.1% to 1.5% w/w lorann oils; and (e)         about 0.01 to 0.4% food coloring.     -   Embodiment 86. The pharmaceutical composition of embodiment 82,         wherein the liquid comprises: (a) about 3-5% w/w citric         acid; (b) about 45-49% w/w blue agave; (c) about 45-49% w/w         glycerin; (d) about 0.7-0.9% w/w lorann oils; and (e) about         0.1-0.3% food coloring.     -   Embodiment 87. The pharmaceutical composition of any one of         embodiments 1-86, for use in the treatment of opioid addiction.     -   Embodiment 88. The pharmaceutical composition of any one of         embodiments 1-86, for use in the treatment of pain.     -   Embodiment 89. The pharmaceutical composition of any one of         embodiments 1-86, for use in the treatment of         chemotherapy-induced nausea and vomiting.     -   Embodiment 90. A method of treating opioid addition, the method         comprising administering an effective amount of a pharmaceutical         composition comprising one or more cannabinoids to a subject in         need thereof.     -   Embodiment 91. The method of embodiment 90, wherein the         pharmaceutical composition is the pharmaceutical composition of         any one of embodiments 1-86.     -   Embodiment 92. The method of embodiment 90 or 91, wherein the         pharmaceutical composition is administered every 1, 2, 3, 4, 5,         6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22,         23, or 24 hours.     -   Embodiment 93. The method of embodiment 90 or 91, wherein the         pharmaceutical composition is administered every 6, 8 or 12         hours.     -   Embodiment 94. The method of any one of embodiment 90-93,         wherein the subjects opioid use decreases by at least 50% within         5 weeks of beginning treatment as determined by morphine         equivalency of opioids used.

Example 1—Exemplary Formulation Preparation

This example details the production of an exemplary cannabinoid formulation that can be used in the methods disclosed herein.

Briefly, 400 g citric acid, 5000 g blue agave, and 5000 g glycerin are mixed and heated to 150° C. Separately, 300 g ethanol is heated and mixed with THC oil and CBD isolate until complete dissolution. Then, both mixtures are combined, flavoring (80 g Lorann Oils, e.g., watermelon, cherry) and coloring (20 g food coloring) are added, and the resulting mixture is sonicated until ingredients are thoroughly incorporated.

The final product is aliquoted to bottles, each containing about 5.5 oz. A single dose is about 12 mL.

The final product can contain, for example, about 15-20 mg THC and about 10-12 mg CBD per dose. The final product can also contain terpenes; for example, 30-60 mg β-myrcene (e.g., about 45 mg), 2.5-5 mg β-caryophyllene (e.g., about 3.7 mg), 2.3-4.7 mg ocimene (e.g., about 3.5), 1.1-2.1 mg α-pinene (e.g., about 1.6), 0.8-1.6 mg α-humulene (e.g., about 1.2 mg), or a combination thereof. Table 2 contains an exemplary recipe.

TABLE 2 Exemplary formulation recipe Batch Size: 10,000 g 16 g formulation = 12 mL volume = 1 dose Percent Amount by Component Added Weight mg/g mg/dose Carriers/Excipients Citric Acid 393.27 g 3.933% Blue Agave 4729.13 g 47.291% Glycerine 4729.13 g 47.291% Flavor: Lorann 78.65 g 0.787% Oils Food Coloring 19.66 g 0.197% Cannabinoids THC 9.38 g 0.094% 0.9375 mg/g 15 mg/dose CBD 6.25 g 0.063% 0.625 mg/g 10 mg/dose Terpenes β-myrcene 28.13 g 0.281% 2.8125 mg/g 45 mg/dose β- 2.31 g 0.023% 0.23125 mg/g 3.7 mg/dose Caryophyllene Ocimene 2.19 g 0.022% 0.21875 mg/g 3.5 mg/dose α-pinene 1.00 g 0.010% 0.1 mg/g 1.6 mg/dose α-humulene 0.75 g 0.008% 0.075 mg/g 1.2 mg/dose

Example 2

Over the last 150 years the perceived and reported medicinal effects or benefits associated with the consumption of products derived from the cannabis plant have fluctuated as much as the most volatile stock market period in history. Periodically, the benefits have been held out to be Olympian in nature, virtually a cure all for all conditions while at other times use of the cannabis has been associated with “reefer madness”; including suicidal ideation, sexual promiscuity, and in general uncontrolled impulses. The truth, as usual lies somewhere in between. Add in a dose of world politics and posturing; difficulty in conducting trials; an error in taxonomy; the radically different effect ascribed to the two main components of the plant, Delta-9 tetrahydrocannabinol (THC) and Cannabidiol (CBD) consumed in a variety of ways; a less than clear understanding of the metabolism of the compounds and the endocannabinoid system; and the inability to link a specific plant profile to a specific outcome have all made it even more difficult in separating the flower from the trim, as it pertains to Cannabis sativa and its medicinal effects.

For the purposes of this forum the historic marketing of cannabis and its by-products will be left to an excellent reference as will references to reefer madness type publications. Regarding world and US politics, our present-day situation, for the most part, is governed nationally by the Nixon administration ignoring the recommendations of the National Commission of Marihuana and Drug Abuse (The Schafer Commission) and its appendix both published in 1972, which overall called for decriminalization of personal possession and use of cannabis. Even this report was not without controversy. To paraphrase a report issued by the Committee on Public Health of the New York Academy of Medicine, it recommended that a government agency investigate the feasibility of control and distribution of marihuana through a government agency, while a New England Journal editorial suggested that legalization offered the best promise for effective control of marihuana. Nahas and Greenwood published a detailed rebuttal to the Shafer Commission report and ultimately the administration ignored the Commission's recommendations. Currently 28 states, the District of Columbia and a few of the over 500 recognized Indian tribal nations have passed laws regulating the sale of cannabis either for medical or both medical and recreational use and the laws enacted by each of these government(s) or their legislation are at odds with federal statute. The recent rescinding of the Cole memorandum by Attorney General Sessions has added fuel to the fires of confusion which unfortunately will not be solved here but all should be left with the warning of “buyer beware”.

Now onto the science. Like staging systems for each cancer, we can all argue the merits of the specifics defining each stage, but none would argue against the need for uniformity. For without it, discussion of results and therefore evaluation of new treatments would be rendered impossible. Cannabis, was taxonomically divided into three species in the 1970s; C. indica, C. sativa, and C. ruderalis. Adding to the confusion, yet ultimately clarifying was the work of McPartland wherein he proved on a genetic basis that these were all the same species, just different subspecies. More importantly he found that C. sativa originated in India and should have been classified as C. indica; C. indica originated in Afghanistan and should have been identified as C. afghanica; and C. ruderalis is most properly classified as C. sativa. Until this nomenclature is standardized comparing research results will be near impossible.

Since Mechooulam's group identified and synthesized both cannabidiol (CBD) and delta-9 tetrahydrocannabinol (THC) the psychoactive component in the cannabis plant there have been over 60 phytocannabinoids the identified in addition to approximately 400 other components of the cannabis plant including a large number of terpenes that account for the associated aroma and may contribute to the entourage effects of cannabis. Research efforts have logically been based upon our understanding of the cannabinoid receptors so far identified throughout the body, but particularly in the brain and metabolism via the cytochrome P450 pathways. Left to further study is the molecular basis for the therapeutic effect of associated with cannabidiol (CBD) as it has little affinity for the CB1 and CB2 receptors. Of most importance at this time has been the identification of CBD acting as a negative allosteric modulator thereby changing the shape of the CBT receptor and thus dampens the psychoactive effect associated with the consumption of THC when taken in combination with CBD.

Much of our collective knowledge regarding the clinical effects of cannibinoids arises from case reports and observational and retrospective studies. There are few prospective randomized trials reported. Many that pertain to clinical oncology involve the use of dronabinol for the relief of chemotherapy-induced nausea and vomiting and pain. May and Giode have thoroughly reviewed much of this literature. Dronabinol has offered little relief over available anti-emetic regimens. Additional prospective studies have been conducted using oromucosal nabiximols (THC:CBD of 1:1) for intractable spasticity in patients with multiple sclerosis (MS) and those results led to the FDA ultimately granting GW Pharmaceuticals (London UK, Carlsbad CA) approval for this indication. Trials using the same product, designed to determine its effectiveness in cancer-associated pain, was not found to be better than placebo. Maccarrone et al have reviewed results of trials involving oromucosal nabiximols. Russo similarly has provided an excellent review on the matter of trial design and other controversies associated with research in this area, including issues involving clinical trial approval and design. Highlighted by Russo are the difficulties encountered when attempting to undertake research involving cannabis, in particular the need to either use cannabis provided exclusively by the University of Mississippi or apply to cultivate and supply your study drug.

In Nevada, efforts to conduct federally-approved research undertaken with the intent of filing a new drug application a has been thwarted as the Institutional Review Board (IRB) at the University Medical Center (UMC) requires DEA assurance before considering any protocol containing cannabis in a treatment arm, yet to obtain federal permission one needs IRB approval of the study of concern.

Addressing the opiate crisis in this country has led to a number of studies being conducted using cannabis-based therapy as an alternative means of managing chronic and cancer-related pain. Despite Nabiximols not appearing to be statistically superior when compared to placebo in controlling pain in cancer patients, there are other randomized placebo controlled trials demonstrating the efficacy of using cannabis for pain control. There is also significant evidence that a cannabis-opioid interaction exists that results in improved pain control. All of the studies to date have either used pain scales or patient interview results to determine the success or failure of the cannabis intervention. Given the increasing availability of legal cannabis, there will be fewer opportunities to study a cannabis naïve population use as it is clear from the work of Bachhuber et al. that patients are self-treating with cannabis in order to reduce if not eliminate their dependence on narcotics. This is reflected by the 24% reduction in opiate-related deaths in states with legalized medical marijuana programs as compared to those without.

We, a group of physicians in Nevada, are licensed to cultivate, produce and sell cannabis-related products and have recently undertaken a randomized, placebo controlled study using a guava-based syrup with a THC:CBD ratio of about 2:1 and a placebo containing only the flavored guava-based syrup. As a proof of concept 25 patients with a history of at least 3 years of chronic opiate use were enrolled in a single arm study with the endpoint being a 30% reduction of opiate intake determined by weekly pill count.

The population of subjects in this study included 14 women and 11 men. The average age of participants was about 55 years old, with the youngest being 21 and the oldest being 77. The median age was about 58 years old. According to their medical histories, 4 participants had a history of gynecologic or breast cancer; 11 participants have had spine surgery; 5 participants have had a hysterectomy; 4 participants reported hypertension; 2 participants reported coronary artery disease, 2 participants had diabetes; 11 participants used tobacco; 6 participants used alcohol; and 3 participants reported drug abuse.

A morphine equivalent calculation was adopted for this study to account for the varying opiates used by the study participants. Hydrocodone alone was used by 9 participants; hydrocodone plus morphine sulfate was used by 1 participant; hydromorphone alone was used by 2 participants; hydromorphone plus methadone was used by 1 participant; oxycodone alone was used by 6 participants; oxycodone plus methadone was used by 1 participant; oxycodone plus morphine sulfate was used by 2 participants; and Percocet was used by 3 participants.

23 of the 25 patients reduced their opiate intake by greater than 50%. The average weekly pill count is charted in FIG. 1 a with regression analysis shown in FIG. 1 b . The average weekly pill counts after conversion to morphine equivalents is shown in FIG. 2 a with regression analysis shown in FIG. 2 b . These results provide an objective basis to evaluate the potential of cannabis to replace to reduce the opiate consumption across the US. We have also opened a trial to evaluate the effectiveness of this syrup with some slight modifications in the terpene profile, in controlling chemotherapy-induced nausea and vomiting (CINV).

References, each of which is incorporated by reference in its entirety:

-   Mills M. Moguls and Mexicans: The American history of cannabis     legalization. The New Econom Mar. 27, 2015. theneweconomy.com. -   National Commission on Marihuana and Drug Abuse: Marihuana: A Signal     of Misunderstanding: First Report of the National Commission on     Marihuana and Drug Abuse. Washington D.C., Govt. Print. Off. 1972. -   National Commission on Marihuana and Drug Abuse: Marihuana: A Signal     of Misunderstanding: Technical papers, Appendix, vols. 1 and 2.     Washington D.C., Govt. Print. Off. 1972. -   Wechsler H. Marihuana, alcohol and public policy. New Eng. J. Med.     287:516-17, 1972 -   Nahas G G, Greenwood A. The first report of the National Commission     on marihuana (1972): signal of misunderstanding or exercise in     ambiguity. Bull N Y Acad Med. 1974 January; 50(1):55-75. -   McPartland J M. “Cannabis sativa and Cannabis indica versus “Sativa”     and “Indica”.” In Cannabis sativa L.—Botany and Biotechnology,     edited by Chandra S, Lata H and ElSohly M A, pp 101-121.     Switzerland: Springer International Publishing, 2017. -   Micholaum R and Shvo Y. Hasish. I. The structure of cannabidiol.     Tetrahedron. 1963 December; 19(12): 2073-8 -   Gaoni Y and Micholaum R. Isolation, Structure, and Partial Synthesis     of an Active Constituent of Hashish. J. Am. Chem. Soc., 1964, 86     (8), pp 1646-1647. -   Howlett AC1, Barth F, Bonner T I, Cabral G, Casellas P, Devane W A,     Felder C C, Herkenham M, Mackie K, Martin B R, Mechoulam R, Pertwee     R G. International Union of Pharmacology. XXVII. Classification of     cannabinoid receptors. Pharmacol Rev. 2002 June; 54(2):161-202. -   Breivogel CS1, Childers S R. The functional neuroanatomy of brain     cannabinoid receptors. Neurobiol Dis. 1998 December; 5(6 Pt     B):417-31 -   Russo E B. Taming THC; potential cannabis synergy and     phytocannabinoid=terpenoid entourage effects. Br J Pharmacol. 2011     August; 163 (7):1344-1364. -   Lapairie R B, Bagher, A M, Kelly, M E Denovan-Wright, E M.     Cannabidiol is a negative allosteric modulator of the cannabinoid     CB1 receptor. Br J Pharmacol. 2015 October; 172(20): 4790-4805. -   May M B and Glode A E. Dronabinol for chemotherapy-induced nausea     and vomiting unresponsive to anti-emetics. Cancer Manag Res. 2016;     8: 49-55. -   Maccarrone M, Maldanado R, Casas M, Henze T, and Centonze D.     Cannabinoids therapeutic use: what is our current understanding     following the introduction of THC, THC:CBD oromucosal spray and     others? Expert Review of Clinical Pharmacology. 2017; 10: 443-55. -   Russo E B. Current Therapeutic Cannabis Controversies and Clinical     Trial Design Issues. Front Pharmacol. 2016; 7: 309-339. -   Lichtman A H, Lux E A, McQuade R, Rossetti s, Sanchez R, Sun W.     Wright S, Komyeyeva E, Fallon M T. Results of a double-blind,     randomized, placebo-controlled study of Nabiximols oromucosal spray     as an adjunctive therapy in advanced cancer patients with chronic     uncontrolled pain. nJ Pain Symptom Manage. 2018; 55: 179-188. -   Abrams D I, Couey P, Shader S B, Kelly M E, Benowitz N I.     Cannabinoid-opioid Interaction in chronic pain. Clin. Pharmacol.     Ther. 2011; 90; 844-851. -   Miller G. Pot and Pain. Hints are emerging that cannabis could be an     alternative to opioid painkillers. Science. 2016: 354; 566-568 -   Whiting P F, Wolff R E, Deshpande S, Di Niso M, Duffy S, Hernandez A     V, Keurentjes J C, Lang S, Misso K, Rider s, Schmidkofer S, Westwood     M, Kleijnen J. Cannabinoids for Medical Use: A systematic review and     meta-analysis. JAMA. 2015; 313; 2456-2473. -   Bachhuber M A, Saloner B, Cunningham C O, Barry C L. Medicinal     cannabis laws and opioid analgesic overdose mortality in the United     States, 1999-2010. JAMA Intern. Med. 2014 174; 1668-1673.

Example 3 A Phase III Double-Blind, Randomized, Placebo Controlled (with Crossover) Trial of Medical Marijuana Versus Placebo for the Reduction of Opiate Consumption in Patients with Chronic Pain

Schema

Arm I: Placebo Arm II: THC/CBD (strain specific) If no improvement If no improvement ↓ ↓ Double the Dose Double the Dose ↓ ↓ If no improvement, Cross-over to If no improvement, Cross-over to Arm II Arm I

Objectives

Primary Objective: To determine if the number of patients consuming opiates for chronic pain treated with medicinal cannabis (15-20 mg THC/10-12 mg CBD-strain specific) in an agave-based syrup that are able to eliminate their opiate consumption is not reduced by 300% when compared to an identical agave-based syrup without cannabis.

Secondary Objective: To determine the incidence of adverse events associated with both regimens. Common Terminology for Adverse Events (CTAE ver. 4) will be used to scale adverse events.

BACKGROUND AND RATIONALE

The available literature on the medicinal effects of cannabis is sparse and for the most part lacks critical aspects of study design including prospective design and randomization. The reasons for this are varied, but primarily they are based on the fact that cannabis remains a schedule 1 drug and its production and ingestion are against federal law. Most studies have evaluated synthetics, nabilone or dronabinol, with few evaluating THC derived from plant. Internationally, over 30 countries have approved its use either recreationally or medicinally. Some countries such as Paraguay and Chile have legalized cultivation and production of cannabis products. Over half of the states and the District of Columbia have legalized the use of cannabis medicinally and some have approved its use recreationally. In the last few years, research into the underlying neurophysiology associated with cannabis has led to an increased understanding of the different active components and the biochemical pathways responsible for the associated therapeutic effects. The constituents seemingly responsible for the claimed medicinal effects of the cannabis plant can include delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD).

The purported beneficial medicinal effects associated with cannabis ingestion are quite diverse. Of the claims made, the most studied are in patients with multiple sclerosis, where a beneficial effect on muscle spasticity and pain are well-documented, but not necessarily as consistently as one might like. Cannabis can also be effective in treating seizures, anorexia, chronic pain, and nausea and vomiting that is associated with chemotherapy. Cannabidiols may also have a therapeutic effect of inflammation, diabetes, cancer, and neurodegenerative diseases. On the other hand THC ingestion has been associated with less than desirable side effects such as agitation; panic disorder; depression and even psychosis.

Perhaps as importantly, the political landscape is changing as rapidly as is the understanding of the underlying mechanisms of action associated with cannabis. Indications of this are the increasing number of states that have legalized the medicinal use of cannabis and the call by some states, such as Nevada, to undertake research to evaluate the clinical benefits associated with the use of cannabis.

The opiate epidemic continues to be associated with over 100 deaths daily in the United States. Couple this with the estimated total annual cost of pain-related health of approximately $600 billion and perhaps this figure is even higher for the nations in European Union (EU) and therein is born the impetus to evaluate virtually any therapy that may thwart these related problems. This estimate includes the actual costs related to the medical care as well as the economic losses which contribute to approximately one-half of these costs. Economic losses include claimed disability, loss of productivity and lost wages. Medical care including physician time, hospitalization, surgical procedures, diagnostic testing and prescription drugs all contribute to the costs associated with the treatment of pain, as well the costs associated with the adverse effects associated with their utilization. Unfortunately, one of the adverse effects associated with prescription painkillers is death. Overdose deaths secondary to prescription opioids were five times higher in 2016 than 2000 and sales of these prescription drugs have quadrupled. That being said, the number of deaths dues to prescription opioids has remained relative stable at approximately 14,000 to 16,000 deaths per year. Much of the increase in mortality related to opioid consumption is due the rapid rise in those associated with the use of synthetic opioids. Of importance is the fact that in state with either medical marijuana or both medical and retail marijuana programs in place there was a 24.8% lower mean annual opioid overdose mortality rate (95% CI, −37.5% to −9.5%: P=0.003) compared with states without medical marijuana laws.

Addressing the opiate crisis in this country has led to a number of studies being conducted using cannabis-based therapy as an alternative means of managing chronic and cancer-related pain. Despite Nabiximols not appearing to be superior when compared to placebo in controlling pain in cancer patients, cannabis may have efficacy for pain control. A cannabis-opioid interaction may also result in improved pain control.

Cannabis contains at least 63 cannabinoids but two are best understood studied. The first, delta-9 tetrahydrocannabinol (THC), is thought to be responsible for the psychoactive effects that are widely associated with cannabis. The other main active component, cannabidiol (CBD), has no known psychoactive effect associated with its consumption but is thought to possibly provide anti-neoplastic, analgesic and antineuroleptic effects. Even though both cannabinoids are present in every plant, the interactions with the cerebral endocannabinoid receptor system are quite different. CBD binds as an antagonist to the cannabinoid receptor CB1 but the bond between THC and the same receptor is at least 100 times stronger. CBD also antagonizes the action on the cannabinoid G protein-coupled receptor GPR55, which is thought to be responsible the different neuromodulatory actions as the CB1 receptor. Claims of the subjective effects associated with cannabis ingestion include improvement in mood; relaxation; and increased sensitivity. On the other hand THC ingestion has been associated with less than desirable adverse effects such as agitation; panic disorder; depression and even psychosis.

Cannabinoids can have an effect on serotonergic systems, including increasing cerebral production of 5-hydroxytryptamine (5-HT), serotonin while decreasing its uptake at the synapse level. THC may also have dopaminergic antagonistic actions which may contribute to its beneficial profile regarding pain control.

Other phytocannabinoids such as cannabichromene (CBC), cannabigerol (CBG) as well as a number of terpenoids may contribute its analgesic effect. CBD, cannabinol (CBN), CBC and CBG can have anti-inflammatory and analgesic effects over and beyond that associated with THC. B-caryophyllene may be a selective CB2 agonist and other terpenes such as linalool and a-Pinene may have analgesic and anti-inflamatory effects respectively. Myrcene on the other hand may have analgesic effects mediated through an opioid-like action. This may lead to another avenue as to how cannabis and it component parts may prevent opiate withdrawal and allow for the use of lesser amounts of opioids while preventing the development of tolerance. Used in combination with opioid pain medications, cannabis can lower opioid side effects, cravings, and withdrawal severity, as well as enhance the analgesic effects of opioids, thereby allowing for lower doses and less risk of overdose.

All of the studies to date have either used pain scales or patient interview results to determine the success or failure of the cannabis intervention.

We have recently undertaken a phase II feasibility trial using a guava-based syrup with a THC:CBD ratio of 1.5:1 to 2:1 derived from a specific cannabis plant with a unique profile of other phytocannabinoids such as CBC, CBN, and CBG as well as a number of terpenoids which likely contribute to its analgesic effect. Each dose of syrup contained 15-20 mg of THC and 10-12 mg of CBD as well as a unique profile associated with one specifically bred cannabis plant. A proof of concept trial of 25 patients with a history of at least 3 years of chronic opiate use were enrolled in a single arm study with the target for success being a 30% reduction of opiate intake determined by weekly pill count. Using a morphine equivalent conversion of all of the various opiates consumed by the study population it was determined that there was a reduction in opiate consumption of approximately 75% and 8/25 patients (40%) were able to replace their prescription opiates with the agave-based THC-CBD syrup. This provides an objective basis to evaluate the potential of cannabis to reduce if not eliminate a significant amount of the opiate consumption across the US. As explained above the actions of THC, CBD, and associated terpenes are potentially complementary and the recent feasibility trial provides substantial evidence of potential benefit of using them together for patients with chronic pain.

That being said another important consideration in administering cannabis to patients is the potential drug-to-drug interactions and adverse effects associated with its use and potential withdrawal. THC is metabolized via the Cytochrome P450 pathway and more specifically it is thought that the CYP2C9 enzyme is responsible for the first pass metabolism of THC. The CYP3A4 enzyme may also have a role in its metabolism. Coumadin effect on prothrombin time (PT) is significantly enhanced by the use of THC/CBD. Theophylline levels may be adversely affected. There have been reported adverse events when cannabis is used with sildenafil, including a myocardial infarction. Since THC is a CNS depressant its use with alcohol, barbiturates, antihistamines, narcotics, and BZD, theoretically could amplify the effects of both drugs. It should be noted there has not been any clinical trial documenting these interactions. Similarly, adverse events need to be carefully documented. In this context cannabinoid receptors are not located in the brainstem as are opioid receptors and therefore do not have the associated risk of respiratory depression and death. Adverse effects including, but not limited to tachycardia and hypotension, anxiety and nervousness, hyperactivity, muscle relaxation, decreased bowel motility, and bronchodilatation have been documented.

The addictive potential of cannabinoids is thought to be lower than opiates and its derivatives as well as other frequently abused substances. Interestingly, as cannabinoids are stored in adipose, excretion takes place over a relatively long-time thus preventing precipitous declines in the plasma concentration and potentially explaining the lack of acute withdrawal symptoms associated with the cessation of cannabis use. Nevertheless, there have been documented symptoms associated with withdrawal including, but not limited to, nausea and vomiting, increased activity, nervousness, irritability, insomnia, and vasomotor symptoms.

This overall safety profile of the cannabinoids made them an excellent candidate to be studied as an opiate substitute. A recently completed pilot study demonstrated in 25 patients, a 75% reduction in opiate ingestion over a 4-5 week period, with 8/25 patients completely discontinuing their opiate use. The same formulation used in that study will be studied here.

Inclusion of Women and Minorities

No potential subject will be excluded from participating in this or any study solely on the basis of ethnic origin or socioeconomic status. Every attempt will be made to enter all eligible patients into this protocol and therefore address the study objectives in a patient population representative of the entire population currently consuming opiates for over three years.

Patient Eligibility and Exclusions

Eligible Patients Criteria

-   -   1) Patients currently consuming opiates chronically for a         minimum of 3 years.     -   2) Patients who can read understand and write English or have a         translator available to do so.     -   3) Patients who are able to complete the assessments.     -   4) Patients who are able to comply with treatment regimen and be         seen on a weekly basis at the study site to have their         medications counted and an assessment completed.     -   5) Patient must hold a valid Nevada Medical Marijuana Card or be         qualified by reciprocity as defined by Nevada Statute.

Ineligible Patients Criteria

-   -   1) Patients who, in the opinion of their physician, have any         condition that may contradict potential withdrawal symptoms         associated potential reduction of opiate ingestion.     -   2) Patients known to have had a hypersensitivity reaction to any         of the drugs to be received as part of this trial.     -   3) Patients currently taking warfarin or similar products.     -   4) Patients taking Tadalafil (Cialis™), Sildenafil (Viagra), or         Theophylline.     -   5) Pregnant patients or patients on oral contraceptives who are         not willing to use another form of back up birth control in         addition to the pill.     -   6) Patients who have used cannabis within the last one month.

Study Modalities

Tetrahydrocannabinol: Cannabidiol (THC:CBD) agave based syrup (20 mg THC/10 mg CBD) vs control agave-based syrup.

Each bottle will contain either 150-200 mg:100-120 mg (THC:CBD) in an agave based syrup with reconstituted terpene profile or the agave-based syrup alone. The emulsification process renders the material virtually odorless allowing for the patient to be blinded.

Storage and Stability: store vials at 2-8° C. (36-46° F.).

Preparation: emulsified solution.

How Supplied: in glass jars with increments and doses labeled on each bottle.

Administration: both are to be administered on a q6 to q8 hour basis (e.g., every 6 to 8 hours) by either direct administration or the syrup is to be mixed with 7-up with care being taken to chew the ice. If ineffective, the patient will double the dose. If there is no improvement then the patient will be crossed-over.

Adverse Events: THC ingestion has been associated with adverse effects such as agitation; panic disorder; depression and even psychosis and all adverse events will be chronicled based on version 4.

Cannabis

Description:

Tetrahydrocannabinol: Cannabidiol (THC:CBD) agave based syrup (15-20 mg THC/10-12 mg CBD) with reconstituted terpene profile versus control agave-based syrup.

Cannabis is intended for use as a psychoactive drug or as a medicine. The main psychoactive part of cannabis is tetrahydrocannabinol (THC); it is one of at least 421 known compounds in the plant, including at least 61 other cannabinoids, such as cannabidiol (CBD), cannabinol (CBN), and tetrahydrocannabivarin (THCV).

Researchers have subsequently confirmed that THC exerts its most prominent effects via its actions on two types of cannabinoid receptors, the CB1 receptor and the CB2 receptor, both of which are G-protein coupled receptors. The CB1 receptor is found primarily in the brain as well as in some peripheral tissues, and the CB2 receptor is found primarily in peripheral tissues, but is also expressed in neuroglial cells THC appears to alter mood and cognition through its agonist actions on the CB1 receptors, which inhibit a secondary messenger system (adenylate cyclase) in a dose dependent manner. These actions can be blocked by the selective CB1 receptor antagonist SR141716A (rimonabant), which has been shown in clinical trials to be an effective treatment for smoking cessation, weight loss, and as a means of controlling or reducing metabolic syndrome risk factors. However, due to the dysphoric effect of CB1 antagonists, this drug is often discontinued due to these side effects. Via CB1 activation, THC indirectly increases dopamine release and produces psychotropic effects. Cannabidiol also acts as an allosteric modulator of the mu and delta opioid receptors. THC also potentiates the effects of the glycine receptors. The role of these interactions in the “marijuana high” remains elusive.

The high lipid-solubility of cannabinoids results in their persisting in the body for long periods of time. Even after a single administration of THC, detectable levels of THC can be found in the body for weeks or longer (depending on the amount administered and the sensitivity of the assessment method). A number of investigators have suggested that this is an important factor in marijuana's effects, perhaps because cannabinoids may accumulate in the body, particularly in the lipid membranes of neurons.

In comparison to smoking and inhalation, after oral ingestion, systemic absorption is relatively slow resulting in maximum Δ9-THC plasma concentration within 1-2 hours which could be delayed by few hours in certain cases. In some subjects, more than one plasma peak was observed. Extensive liver metabolism probably reduces the oral bioavailability of Δ9-THC by 4-12%. After oral administration, maximum Δ9-THC plasma concentration was 4.4-11 ng/mL for 20 mg and 2.7-6.3 ng/mL for 15 mg. Much higher concentration of 11-OH THC was produced after ingestion than inhalation. Following assimilation via the blood, Δ9-THC rapidly penetrates in to fat tissues and highly vascularized tissues including brain and muscle resulting in rapid decrease in plasma concentration. This tissue distribution is followed by slow redistribution of it from the deep fat deposits back into the blood stream. It should be noted that the residual Δ9-THC levels are maintained in the body for a long time following abuse. The half-life of it for an infrequent user is 1.3 days and for frequent users 5-13 days. After smoking a cigarette containing 16-34 mg of Δ9-THC, THC—COOH is detectable in plasma for 2-7 days. A clinical study carried out among 52 volunteers showed that THC—COOH was detectable in serum from 3.5 to 74.3 hours. Initial concentration was between 14-49 ng/mL. This was considerably less than the THC—COOH detection time of 25 days in a single chronic user.

Δ9-THC is metabolized in the liver by microsomal hydroxylation and oxidation catalyzed by enzymes of cytochrome P450 (CYP) complex. The average plasma clearance rates have been reported to be 11.8±3 L/hour for women and 14.9±3.7 L/hour for men. Others have determined approximately 36 L/hour for naïve cannabis users and 60 L/hour for regular cannabis users. More than 65% of cannabis is excreted in the feces and approximately 20% is excreted in urine. Most of the cannabis (80-90%) is excreted within 5 days as hydroxylated and carboxylated metabolites. There are eighteen acidic metabolites of cannabis identified in urine and most of these metabolites form a conjugate with glucuronic acid, which increases its water solubility. Among the major metabolites (Δ9-THC, 11-OH-THC, and THCCOOH), THCCOOH is the primary glucuronide conjugate in urine, while 11-OH-THC is the predominant form in feces. Since Δ9-THC is extremely soluble in lipids, it results in tubular re-absorption, leading to low renal excretion of unchanged drug. Urinary excretion half-life of THCCOOH was observed to be approximately 30 hours after seven days and 44-60 hours after twelve days of monitoring. After smoking approximately 27 mg of Δ9-THC in a cigarette, 11-OH-THC peak concentration was observed in the urine within two hours in the range of 3.2-53.3 ng/mL, peaking at 77.0±329.7 ng/mL after 3 hours and THCCOOH peaking at 179.4 ng/mL±146.9 after 4 hours.

Stability and Storage

Store at room temperature in a colored bottle to avoid decomposition of the THC.

Preparation

The syrup is prepared using CO2 extracted THC which is then decarboxylated. The syrup is composed of agave syrup, glycerin, citric acid, lecithin, THC/CBD oil, coloring and flavoring. Each bottle, marked on the sides in 12 millimeter increments, will contain a total of 150-200 mg of THC and approximately 100-120 mg of CBD and will provide ten doses of medicine. The placebo will be the identical mixture without the addition of THC/CBD oil.

Administration

The patient will ingest 12 ml of either placebo or medicinal cannabis containing approximately 15-20 mg of THC and 10-12 mg CBD with the plant-specific terpenes reconstituted on a QID basis. The patients will be allowed to double the dose if symptoms to do not resolve.

Adverse Events

Short-term adverse effects include alterations in short-term memory, sense of time, sensory perception, attention span, problem solving, verbal fluency, reaction time, and psychomotor control. Some users report positive feelings such as mild euphoria and relaxation, while others, particularly naive users, report anxiety, paranoia, and panic reactions. Depression and anxiety have also been reported as short-term adverse events. The short-term effects of marijuana last approximately 1-4 hours, depending on potency of the marijuana, the route of administration, and the tolerance of the user. Furthermore, there have been reports of adverse cardiac events including arrhythmias associated with a prolonged Q-T interval; hypertension and hypotension; tachycardia; and myocardial infarction. It is much more difficult to assess long-term adverse effects that may be attributable to the consumption of medicinal cannabis. While there is no question that marijuana causes short-term impairments in brain function, the degree to which these impairments are reversible with chronic use is less clear. Some studies have shown that brain function recovers over time, while others demonstrate persistence of subtle, but important, impairments. There is some suggestion that schizophrenia may be associated with long-term usage of cannabis. Lastly, there are the general concerns of smoking associated with cannabis use although that is not of concern as it relates to this study as the cannabis will be ingested and not inhaled.

Drug Interactions

Δ 9-THC is metabolized in the liver by microsomal hydroxylation and oxidation catalyzed by enzymes of cytochrome P450 (CYP) complex. As a result any drug that is similarly metabolized may be affected. Particular attention must be given to warfarin or similar products; tadalafil or similar products; and anti-depressants.

Treatment Plan and Entry

IRB Approval and IRB-Approved Informed Consent

Patient Entry and Registration

Treatment Plan

This is a double-blind phase III prospective randomized two-arm study which will be conducted in patients with chronic pain with a history of at least 3 years use of opiates for analgesia. Patients will be randomized using a computer based randomization program off-site and overseen by the independent observer. Patients will start the study within 2 days of filling their opiate prescription and verification through the Nevada State Prescription Monitoring Program that the patient is receiving narcotics from only a single source. The total morphine milligram equivalents (MME) used weekly by the subject will be calculated based on the CDC conversion table. Subjects will be given a diary to record time and amount of study medication used on a daily basis in addition to recording any adverse events. Diaries will be collected weekly. Patients will be given physician phone number in order to report any adverse event.

Week 1. Patients are to use syrup (A or B) as directed on a q 6 hour basis and use their opiates only for breakthrough pain. The patient will be seen at the end of each week and a pill count will be done to determine the quantity of opiate (MME) consumed by the subject and recorded.

Weeks 2-7. At the end of week 2 if there has been no improvement as determined by at least a 20% reduction in total MME used compared to the baseline, the patient will crossed over and continued on the new syrup for a minimum of two additional weeks and if no reduction of at least 20% in total MME study treatment will be discontinued. If the patient's consumption of MME decreases by more than 20% within the first two weeks after initial drug assignment or after two weeks after being crossed-over, the patient will continue on the study drug for at least 4 additional weeks. The patient will be followed through the end of the study with collection of all study data.

Treatment Modifications

Before cross-over has taken place if there is no improvement from the patient's baseline assessment the dose of either the placebo or THC/CBD will be doubled. Within two weeks after cross-over should the total MME used not decrease by at least 20% the subject will be recorded as a failure of study treatment.

Study Parameters

Observations and Tests

The following observations and tests are to be performed and recorded on the appropriate form(s):

Baseline or Day Day Day Day Day Day Days 8, 15, 22, PARAMETER Day 1 2 3 4 5 6 7 29, 36, 43 History & Physical 1 Medication diary X** X X X X X X 2 Pill count and MME calculation X** X X X X X X 2 Gen Chemistry Panel: Electrolytes: 1 3 CBC c diff: PT/INR Toxicity Diary & Assessment X  X X X X X X 2

-   -   1. The baseline History and Physical done will be used if         performed within 30 days of entry.     -   2. Patients will return the Medication Diary weekly. The         toxicity assessment will be completed daily by the patient and         tabulated weekly unless grade 3 or greater toxicity occurs.     -   3. Additional blood work will be ordered by the treating         physician as needed.

Evaluation Criteria

The MME calculated at study entry, weekly and then at completion will be used to determine treatment course as well as the success or failure of the study drug.

The patients will complete a daily medication and toxicity diary and will be assessed weekly.

Parameters of Response

Amount of opiate consumed by pill count and MME will be recorded in the medication diary and by the physicians conducting the study. The primary outcome is the complete elimination of opiate used to control the subject's symptoms.

Secondary outcome is the percentage reduction of opiate used to control the subject's symptoms as measured by pill count and MME.

Adverse events will be documented by the study subjects and verified by the physicians conducting the study

Duration of Study

The duration of the study will be 4 weeks at a minimum unless subject withdraws voluntarily or is caused to withdraw secondary to an adverse event deemed severe enough either by the patient or treating physician to warrant the subject's withdrawal from the protocol prescribed treatment plan.

Study Monitoring and Reporting Procedures

Adverse Event Reporting For A Commercial Agent

Definition of Adverse Events (AE)

An adverse event (AE) is any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease that occurs in a patient administered a medical treatment, whether the event is considered related or unrelated to the medical treatment. The descriptions and grading scales found in the revised NCI Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 will be utilized for AE reporting. All appropriate treatment areas should have access to a copy of the CTCAE version 4.0.

Definition of Serious Adverse Event (SAE)

A Serious Adverse Event (SAE) is defined as any untoward medical occurrence that at any dose:

-   -   1. Results in death     -   2. Is life threatening (i.e., the subject was, in the opinion of         the investigator, at immediate risk of death from the event as         it occurred); it does not refer to an event which hypothetically         might have caused death if it were more severe     -   3. Requires or prolongs inpatient hospitalization     -   4. Results in persistent or significant disability/incapacity         (i.e., the event causes a substantial disruption of a person's         ability to conduct normal life functions)     -   5. Results in a congenital anomaly/birth defect     -   6. Requires intervention to prevent permanent impairment or         damage     -   7. Is an important and significant medical event that may not be         immediately life threatening or resulting in death or         hospitalization but, based upon appropriate medical judgment,         may jeopardize the patient/subject or may require intervention         to prevent one of the other outcomes listed above.

Reporting Expedited Adverse Events

An AE report may need to reach multiple destinations. All expedited AEs will be reported to the IRB or the supervising body overseeing this study. Reporting will be modeled after AdEERS submissions. All adverse reactions will be immediately directed to the Study Chair for further action.

Note: All deaths on study require both routine and expedited reporting regardless of causality. Attribution to treatment or other cause must be provided.

Expedited AE Reporting Timelines Defined:

“24 hours; 3 calendar days”—The investigator must initially report the AE within 24 hours of learning of the event followed by a complete report within 3 calendar days of the initial 24-hour report.

“7 calendar days”—A complete report on the AE must be submitted within 7 calendar days of the investigator learning of the event. Any medical event equivalent to CTCAE grade 3, 4, or 5 that hospitalization (or prolongation of existing hospitalization) must be reported regardless of attribution and designation as expected or unexpected with the exception of any events identified as protocol-specific expedited adverse event reporting exclusions.

AEs should be reported by the investigator.

Pilot Trials Utilizing a Commercial Agent: AdEERS Expedited Reporting Requirements for Adverse Events That Occur Within 30 Days of the Last Dose of Any Study Agent

Reporting Requirements for Adverse Events that occur within 30 Days of the Last Dose of the Commercial Agent on Pilot Trials—GUIDELINES TO BE FOLLOWED regarding reporting of AEs to the Principal Investigator and the IRB

Grade 3 Grade 3 Grade 1 Unexpected With Expected With Unexpected Hospitalization Hospitalization Grades Grades and Grade 2 Grade 2 Without Without 4 & 5² 4 & 5² Expected Unexpected Expected Hospitalization Hospitalization Unexpected Expected Unrelated Not Not Not 7 Not 7 Not 7 7 Unlikely Required Required Required Calendar Required Calendar Required Calendar Calendar Days Days Days Days Possible Not 7 Not 7 7 7 Not 24-Hrs; 3 7 Probable Required Calendar Required Calendar Calendar Calendar Required Calendar Calendar Definite Days Days Days Days Days Days ¹ Adverse events with attribution of possible, probable, or definite that occur greater than 30 days after the last dose of treatment with a commercial agent require reporting as follows: AdEERS 24-hour notification followed by complete report within 3 calendar days for: Grade 4 and Grade 5unexpected events AdEERS 7 calendar day report:. Grade 3 unexpected events with hospitalization or prolongation of hospitalization and Grade 5 expected events ²Although an AdEERS 24-hour notification is not required for death clearly related to progressive disease, a full report is required as outlined in the table. Please see exceptions below under the section entitled, “Additional Instructions or Exceptions to AdEERS Expedited Reporting Requirements for Pilot Trials Utilizing a Commercial Agent.” March 2005

Any event that results in persistent or significant disabilities/incapacities, congenital anomalies, or birth defects must be reported to the Study Chair if the event occurs following treatment with a commercial agent.

Additional Instructions or Exceptions to AdEERS Expedited Reporting Requirements for Pilot Trials Utilizing a Commercial Agent will be applied to this study:

In rare cases, pregnancy might occur in clinical trials. Any pregnancy occurring in association with the use of the study medication and the pregnancy outcome must be reported within five days of first awareness.

The event of overdose of aprepitant is considered an SAE by the manufacturer. In the event that there is an overdose of aprepitant, report the overdose and any clinical consequences that occur in association with an overdose.

Procedures for Expedited Adverse Event Reporting:

Expedited Reports: Expedited reports are to be submitted to the study Chair and the IRB using reports similar to the AdEERS.

Data Management Forms

The following forms must be completed for all patients and must be received in the study office in accordance with the schedule below.

Due within Form^(±) Weeks Event Copies* Comments History and Physical¹ 4 Registration 1 Consent 4 Registratiom 1 Submit to study co-ordinator Patient Symptom Diary 4 weekly 1 Submit to study co-ordinator Pill count and MME log 2 weekly 1 Submit to study co-ordinator T (Toxicity) Form 2 weekly 1 Submit to study co-ordinator AE report See protocol 1 Submit to study co-ordinator Form R 2 Registration 1 Submit to study co-ordinator ¹The History and Physical It is not necessary to repeat for this study.

Statistical Considerations

Study Design

This is a randomized, 2-arm, double-blind, placebo-controlled phase III clinical trial evaluating THC/CBD as an aid to stopping opioid patients who are taking opioids due to chronic pain.

The overall objective of this study is to evaluate the probability of stopping opioid use within 5 weeks for patients diagnosed with chronic pain and treated with THC/CBD compared to those receiving placebo.

Treatment allocation and Emergency Unblinding

The subjects enrolled into this study will receive either daily THC/CBD or a placebo. The study treatments will be sequentially allocated from predetermined lists consisting of randomly permuted study treatments within blocks. This allocation procedure will tend to allocate each of the study regimens to nearly an equal number of the enrollees. Other than blocking the treatments, the randomization procedure will not be otherwise constrained to provide an equal number of subjects in each treatment group. The randomized treatment for each individual will remain concealed unless there arises a need for emergency unblinding. Emergency unblinding occurs when the appropriate clinical care of the subject requires knowledge of her study treatment. The study's Principle Investigator will be responsible for reviewing and approving requests for emergency unblinding. An independent statistician will be responsible for revealing the study treatment.

Measures of Efficacy and Safety

The principal observation for evaluating the therapeutic efficacy and safety of the study regimens are:

Primary Endpoints:

Primary efficacy endpoint: cessation of opioids for at least 7 days as determined by the treating physician.

Primary safety endpoint: Common Terminology Criteria for Adverse Events (CTCAE)—version 4.0.

Secondary Endpoints:

Weekly morphine equivalency does (MED).

Pain Numeric Score (PNS)

Enrollment and Target Sample Size

The target enrollment for this study is 64 subjects. The estimated accrual rate is 6 subjects per month. At this rate the enrollment period for this study is expected to require at most 1 year.

In order to account for the loss in power due to non-compliance, the target sample size will be increased by 2 subjects for each subject who withdraws from the study prior to completing at least 4 weeks of treatment or cannot be adequately evaluated for opioid usage.

Study Hypotheses

Null Hypotheses for Primary Efficacy Endpoint:

H₀: THC/CBD does not increase the probability of stopping opioids within 5 weeks of starting THC/CBD compared to placebo.

Type I Error Allocation

The type I error for the primary efficacy hypothesis will be 0.025 for a one-tail test.

Analytic Procedures for Testing Hypothesis (H0)

Primary Analysis:

For the primary analysis subjects will be group according to their randomly assigned treatment and they will be included in the analysis, regardless of their compliance with their assigned treatment plan. Individuals who withdraw early from the study without stopping opioids will be classified in the analysis of the primary endpoint as treatment failures (i.e., not stopping opioids).

Inferences regarding the clinical significance of THC/CBD will be made based on a Fisher's exact test of the primary study hypothesis.

Secondary and Exploratory Analyses:

A logistic model will be used to assess whether the subject's initial morphine equivalency dose (MED), age or other clinical or demographic factors are treatment effect modifiers.

A linear mixed model will be used to model the patients' weekly morphine equivalency dose over time for women randomized to placebo vs those randomized to THC.

Statistical Power

With 32 subjects treated on each of the study regimens, this design provides 82% chance of rejecting the primary null hypothesis for efficacy when the true probabilities of stopping opioids within 5 weeks are 5% and 35% for placebo and active, respectively.

Interim Analyses

An interim futility analysis will be performed when there are at least 16 subjects treated and evaluated in each of the randomized treatment groups. If the proportion of the subjects randomly assigned to placebo who stopped all opioid usage within 5 weeks is greater than or equal to the proportion of subjects on THC/CBD, then consideration will be given to stopping the study. Otherwise, the study will continue to accrue until the target enrollment has been attained. If the study is stopped early due to this stopping boundary, then the conclusion of the study will be that it is unlikely that THC/CBD increases the probability of stopping opioid use in patients with chronic pelvic pain.

If the true probability stopping opioids on THC/CBD is equal to placebo, then there is a 64% chance that this stopping boundary will recommend stopping the study early. On the other hand, if the true probabilities for stopping opioids are 5% and 35% on placebo and THC/CBD, respectively, then this stopping boundary decreases the statistical power of the study by less than 0.5%.

Interim and final reports will include an accounting of all subjects registered onto the study, regardless of their eligibility status or compliance to their assigned treatment.

The Data Monitoring Committee (DMC) is responsible for reviewing the results of interim analyses. The decision to terminate accrual to the study or to release study results early includes consideration of adverse events, treatment compliance, as well as results from external studies.

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While preferred embodiments of the present invention have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the invention. It should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention. It is intended that the following claims define the scope of the invention and that methods and structures within the scope of these claims and their equivalents be covered thereby. 

What is claimed is:
 1. A method of treating chronic pain in a subject in need thereof, the method comprising orally administering to the subject in need thereof an effective amount of a liquid pharmaceutical composition in unit dose form comprising tetrahydrocannabinol (THC) and cannabidiol (CBD) and a terpene; and wherein the liquid pharmaceutical composition comprises 15-20 mg of the THC per dose, and 10-12 mg of the CBD per dose, thereby treating the chronic pain.
 2. The method of claim 1, wherein the liquid pharmaceutical composition is administered every 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, or 24 hours.
 3. The method of claim 1, wherein the liquid pharmaceutical composition is administered every 6, 8, or 12 hours.
 4. The method of claim 1, wherein the liquid pharmaceutical composition is administered every 6 to 8 hours.
 5. The method of claim 1, wherein the liquid pharmaceutical composition further comprises a citric acid, a blue agave, a glycerine, a food coloring, or any combination thereof.
 6. The method of claim 1, wherein the subject is a subject who is currently treated for the chronic pain by administration of an opioid.
 7. The method of claim 6, wherein the subject's opioid use decreases by greater than or equal to 50% within 5 weeks of beginning treatment as determined by morphine equivalency of opioids used.
 8. The method of claim 1, wherein the liquid comprises a syrup. 